Synaptotagmin-1 antagonizes paraquat intracellular accumulation and nephrocyte toxicity by up-regulating SERBP1/GLUT2 expression.

Acute kidney injury (AKI) is common and an independent risk factor for mortality in patients with paraquat (PQ) poisoning. Currently, no specific antidote is available. Synaptotagmin-1 (SYT1) has been identified as a key protein that facilitates PQ efflux in PQ-resistant A549 cells, thereby preventing PQ-induced lung injury.

A real-world pharmacovigilance study of FDA adverse event reporting system events for atogepant.

Background: Atogepant, an orally administered, small-molecule, calcitonin gene-related peptide (CGRP) receptor antagonist, is being investigated for the treatment of migraine.

Methods: We collected data from the US Food and Drug Administration Adverse Event Reporting System (FAERS) database. Four algorithms (ROR, PRR, BCPNN, and EBGM) were used as measures to detect signals of atogepant-associated adverse events (AEs) in real-world data.

Observation of elliptically polarized light from total internal reflection in bubbles.

Bubbles are ubiquitous in the natural environment, where different substances and phases of the same substance forms globules due to differences in pressure and surface tension. Total internal reflection occurs at the interface of a bubble, where light travels from the higher refractive index material outside a bubble to the lower index material inside a bubble at appropriate angles of incidence, which can lead to a phase shift in the reflected light. Linearly polarized skylight can be converted to elliptically polarized light with efficiency up to 53% by single scattering from the water-air interface.

Circularly and elliptically polarized light under water and the Umov effect.

Total internal reflection occurs when light is incident on the interface of high- and low-refractive-index materials at an angle greater than the critical angle. Sunlight with high degree of linear polarization, such as atmospheric scattered skylight, can be converted with a high efficiency up to 53% to circular and elliptical polarizations by total internal reflection under water in the region outside Snell's window. The degree of circular polarization is observed to be inversely dependent on the albedo of underwater objects and is shown to be a direct consequence of the Umov effect.

Eavesdropping of display devices by measurement of polarized reflected light.

Display devices, or displays, such as those utilized extensively in cell phones, computer monitors, televisions, instrument panels, and electronic signs, are polarized light sources. Most displays are designed for direct viewing by human eyes, but polarization imaging of reflected light from a display can also provide valuable information. These indirect (reflected/scattered) photons, which are often not in direct field-of-view and mixed with photons from the ambient light, can be extracted to infer information about the content on the display devices.

Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsets.

Cross-presentation is the mechanism by which exogenous Ag is processed for recognition by CD8(+) T cells. Murine CD8α(+) DCs are specialized at cross-presenting soluble and cellular Ag, but in humans this process is poorly characterized. In this study, we examined uptake and cross-presentation of soluble and cellular Ag by human blood CD141(+) DCs, the human equivalent of mouse CD8α(+) DCs, and compared them with human monocyte-derived DCs (MoDCs) and blood CD1c(+) DC subsets.

Thermally driven continuous-wave and pulsed optical vortex.

We demonstrated a continuous-wave (cw) and pulsed optical vortex with topological charges driven by heat generated during the lasing process without introducing the astigmatism effect and reducing lasing efficiency. During the lasing process, the topological charges were changeable by the thermal-induced lens and selected by the mode-matching between the pump and oscillating beams. With a graphene sample as the saturable absorber, a pulsed optical vortex was achieved at a wavelength of 1.

FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo.

We established a humanized mouse model incorporating FLT3-ligand (FLT3-L) administration after hematopoietic cell reconstitution to investigate expansion, phenotype, and function of human dendritic cells (DC). FLT3-L increased numbers of human CD141(+) DC, CD1c(+) DC, and, to a lesser extent, plasmacytoid DC (pDC) in the blood, spleen, and bone marrow of humanized mice. CD1c(+) DC and CD141(+) DC subsets were expanded to a similar degree in blood and spleen, with a bias toward expansion of the CD1c(+) DC subset in the bone marrow.

Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli.

Human blood myeloid DCs can be subdivided into CD1c (BDCA-1)(+) and CD141 (BDCA-3)(+) subsets that display unique gene expression profiles, suggesting specialized functions. CD1c(+) DCs express TLR4 while CD141(+) DCs do not, thus predicting that these two subsets have differential capacities to respond to Escherichia coli. We isolated highly purified CD1c(+) and CD141(+) DCs and compared them to in vitro generated monocyte-derived DCs (MoDCs) following stimulation with whole E.

Screening of the HLDA9 panel on peripheral blood dendritic cell populations.

Dendritic cells (DC) are a heterogeneous population of bone marrow derived leucocytes that are essential in the initiation of primary T lymphocyte responses. DC are identified as Lineage negative, HLA-DR(+) blood cells that can be further subdivided by CD11c to distinguish CD11c(+) DC and the CD11c(-) plasmacytoid DC. Plasmacytoid DC are the primary IFNα producing cells and express CD303, CD304 and CD123.

The CD300 molecules regulate monocyte and dendritic cell functions.

The CD300 glycoproteins are a family of related leucocyte surface molecules that modulate a diverse array of cell processes via their paired triggering and inhibitory receptor functions. All family members have a single Ig-V like domain and they share a common evolutionary pathway. At least one member of the family has undergone significant positive selection (ranked second in the top 50) indicating a need to maintain some crucial function.