Publications by authors named "Yishu Liu"

Spinal cord injury (SCI) represents a significant neurological disorder that profoundly impacts human life. Transplantation of extracellular vesicles (EVs) from human umbilical cord mesenchymal stem cells (hUC-MSCs) has emerged as a promising therapeutic strategy. microRNA (miRNA) containing EVs serve as crucial mediators of intercellular communication, playing vital roles in physiological and pathological processes.

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Background: Patellar fractures present challenges in treatment, with traditional methods often leading to complications such as loss of reduction and implant failure. This study aimed to compare a novel suture fixation technique with the traditional tension band method using finite element analysis.

Methods: CT images of a healthy 35-year-old male were used to construct 3D patellar models.

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Background: Spinal cord injury (SCI) inflicts a severe burden on patients and lacks effective treatments. Owing to the poor regenerative capabilities of endogenous oligodendrocyte precursor cells (OPCs) following SCI, there is a growing interest in alternative sources, such as human umbilical cord mesenchymal stem cells (HUCMSCs). TET3 is a key DNA demethylase that plays an important role in neural differentiation, but its role in OPC formation is not well understood.

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Determining the time since deposition (TsD) of body fluid stains can provide crucial criminal information to forensic researchers. Although there are studies on inferring residual time through DNA and RNA markers, this requires high sample quality, and microorganisms, as a new type of marker with individual and tissue identification capabilities, have the potential for body fluid recognition and TsD inference. Blood and semen are the most common types of bodily fluid stains at crime scenes, but research on the inference of the TsD of these two types of stains through microorganisms still needs to be explored.

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Network pharmacology is an interdisciplinary field that utilizes computer science, technology, and biological networks to investigate the intricate interplay among compounds/ingredients, targets, and diseases. Within the realm of traditional Chinese medicine (TCM), network pharmacology serves as a scientific approach to elucidate the compatibility relationships and underlying mechanisms of action in TCM formulas. It facilitates the identification of potential active ingredients within these formulas, providing a comprehensive understanding of their holistic and systematic nature, which aligns with the holistic principles inherent in TCM theory.

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This investigation evaluates the utility and benefits of integrating interprofessional education (IPE) into laparoscopic training, aiming to enrich medical education and skill acquisition methodologies. The study randomly allocated 36 participants of a 2023 laparoscopic training course into experimental and control groups, each comprising 18 individuals. The control group underwent traditional theory and practical training, whereas the experimental group additionally engaged in interdisciplinary instruction with nursing educators and participated in simulated laparoscopic surgery exercises.

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Background: The expression profiles of differentially expressed genes (DEGs) during pupal development have been demonstrated to be vital in age estimation of forensic entomological study. Here, using forensically important (Diptera: Calliphoridae), we aimed to explore the potential of intrapuparial stage aging and postmortem interval (PMI) estimation based on characterization of successive developmental transcriptomes and gene expression patterns.

Methods: We collected pupae at 11 successive intrapuparial stages at 20 °C and used the RNA-seq technique to build the transcriptome profiles of their intrapuparial stages.

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Article Synopsis
  • Congenital lung malformation (CLM) significantly contributes to infant mortality, yet there is a lack of clear classification criteria for its forensic identification, complicating death investigations in neonates.
  • A retrospective study analyzed neonatal autopsy cases from 2008 to 2023, noting increased autopsy rates initially due to improved awareness and resources, followed by a decline potentially linked to advancements in medical technology.
  • The research highlights that respiratory diseases, asphyxia, and congenital issues are major causes of neonatal deaths, emphasizing the need for standardized autopsies and further studies on the genetic factors related to CLM.
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The regenerative treatment of infectious vertical bone defects remains difficult and challenging today. Current clinical treatments are limited in their ability to control bacteria and infection, which is unfavorable for new bone formation and calls for a new type of material with excellent osteogenic and antibacterial properties. Here a multifunctional scaffold is synthesized that mimics natural bone nanostructures by incorporating silver nanowires into a hierarchical, intrafibrillar mineralized collagen matrix (IMC/AgNWs), to achieve the therapeutic goals of inhibiting bacterial activity and promoting infectious alveolar bone augmentation in rats and beagle dogs.

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Objective: To compare the GABA+/Glx (glutamate-glutamine) ratio in the prefrontal lobe under non-rapid eye movement sleep between patients with narcolepsy type 1 (NT1) and normal controls and explore the correlation between this difference and abnormal cognitive function, using synchronous electroencephalography-functional magnetic resonance spectroscopy (EEG-fMRS).

Methods: MRS measurements of GABA+ and Glx concentrations as well as synchronous EEG data were obtained from 26 medication-naive patients with NT1 and 29 sex- and age-matched healthy community volunteers. Cognition was appraised with the Beijing version of the Montreal Cognitive Assessment, and daytime sleepiness was measured using the Epworth Sleepiness Scale.

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Article Synopsis
  • The study investigates the total flavonoids from Desmodium styracifolium, which is used in China to treat urolithiasis, focusing on specific flavonol glycosides as active compounds.
  • Using a validated HPLC-MS/MS method, the researchers measured how these compounds bind to plasma proteins in both rat and human plasma.
  • Results showed varying binding affinities, with isovitexin having significantly higher plasma protein binding compared to other flavonoids, and minimal interaction risk with nonsteroidal anti-inflammatory drugs (NSAIDs) was found.
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The application of network formulaology and network pharmacology has significantly advanced the scientific understanding of traditional Chinese medicine (TCM) treatment mechanisms in disease. The field of herbal biology is experiencing a surge in data generation. However, researchers are encountering challenges due to the fragmented nature of the data and the reliance on programming tools for data analysis.

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The aim of this study was to identify serum diagnostic biomarkers associated with the severity of obstructive sleep apnea (OSA) during pregnancy. Differentially expressed proteins (DEPs) were identified in the control (C), mild (O), and moderate (MO) OSA groups ( = 3 in each group). Bioinformatics analysis was conducted to identify the underlying functions, pathways, and networks of the proteins.

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  • The study investigated the effects of long-term sodium reduction using a potassium-enriched salt substitute on headache frequency and severity in a rural Chinese population.
  • Despite enrolling nearly 21,000 participants, results showed no significant differences in headache occurrence (27% in the salt substitute group vs. 26.6% in the control group) or severity between the two groups.
  • The conclusion suggests that long-term use of the salt substitute did not alleviate headaches, indicating that sodium reduction alone may not be effective for headache management.
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The Salt Substitute and Stroke Study (SSaSS) demonstrated significant reductions in systolic blood pressure (SBP), and the risk of stroke, major cardiovascular events and total mortality with the use of potassium-enriched salt. The contribution of sodium reduction versus potassium increase to these effects is unknown. We identified four different data sources describing the association between sodium reduction, potassium supplementation and change in SBP.

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Article Synopsis
  • The study aims to analyze changes in systolic and diastolic blood pressure trends among adults in Shenzhen from 1997 to 2018, using a cross-sectional design.
  • Data were gathered from over 26,000 residents aged 18-69 through cluster sampling in three specific years: 1997, 2009, and 2018.
  • Findings showed significant increases in both systolic and diastolic blood pressure for males and females, with a marked rise in hypertension rates among males, while female rates remained stable; awareness and treatment rates for hypertension declined during this period.
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Animal models are crucial for advancing our understanding of mild traumatic brain injury (mTBI) and guiding clinical research. To achieve meaningful insights, developing a stable and reproducible animal model is essential. In this study, we report a detailed description of a closed-head mTBI model and a representative validation method using Sprague-Dawley rats to verify the modeling effect.

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Zirconia materials have been increasingly used in implant rehabilitation due to their excellent physical and esthetic properties. Stable peri-implant epithelial tissue adhesion to the transmucosal implant abutment may significantly enhance the efficacy of implant long-term stability. However, it is difficult to form stable chemical or biological bindings with peri-implant epithelial tissue due to the strong biological inertia of zirconia materials.

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Reliable diagnostic methods for mild traumatic brain injury (mTBI) are lacking, and many researchers continue to search for objective biomarkers that can both define and detect mTBI. Although much research has been conducted in this field, there have not been many bibliometric studies. In this study, we aim to analyze the development over the last two decades in scientific output relating to the diagnosis of mTBI.

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Several studies have isolated chondroitin sulphate (CHS) from sharks' jaws or cartilage. However, there has been little research on CHS from shark skin. In the present study, we extracted a novel CHS from skin, which has a novel chemical structure and bioactivity on improvement in insulin resistance.

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A copper-catalyzed C3 amination of 2-indazoles with 2-indazoles and indazol-3(2)-ones under mild conditions was developed. A series of indazole-containing indazol-3(2)-one derivatives were produced in moderate to excellent yields. The mechanistic studies suggest that the reactions probably proceed through a radical pathway.

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Prior studies for the task of severity assessment of COVID-19 (SA-COVID) usually suffer from domain-specific cognitive deficits. They mainly focus on visual cues based on single cognitive functions but fail to reconcile the valuable information from other alternative views. Inspired by the cognitive process of radiologists, this paper shifts naturally from single-symptom measurements to a multi-view analysis, and proposes a novel Self-paced Multi-view Learning (SPML) framework for automated SA-COVID.

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The potential for using routinely collected data for medical research in China remains unclear. We sought to conduct a scoping review to systematically characterise nation-wide routinely collected datasets in China that may be of value for clinical research. We searched public databases and the websites of government agencies, and non-government organizations.

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Article Synopsis
  • - The study explored the composition and bioactivities of phospholipids (denoted as -PL) found in crab eggs, identifying 12 types of phospholipids with a predominance of polyunsaturated fatty acids like EPA and DHA.
  • - Animal experiments demonstrated that -PL effectively reduced weight gain, fat accumulation, and inflammation in mice fed a high-fat diet, while also improving metabolic indicators such as blood glucose and insulin levels.
  • - Additionally, -PL positively influenced gut microbiota, notably decreasing the Firmicutes/Bacteroidetes ratio and increasing beneficial short-chain fatty acids, which suggests its potential as a food supplement for managing obesity and promoting gut health.
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Purpose: To investigate the optimal closure time of a temporary ileostomy in patients with rectal cancer receiving anus-preserving operation.

Methods: Patients with rectal cancer were enrolled from the Affiliated Hospital of Jiangsu University from May 2010 to June 2019. The eligible patients were grouped according to their actual ileostomy closure time after stoma creation.

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