Phytoestrogens: Pharmacological Potential and Therapeutic Insights for Urinary Tract Infections.

Urinary tract infections (UTIs) are exceptionally common in postmenopausal female or patients with diabetes mellitus or nephrolithiasis, carrying substantial burden on patients and healthcare system. Increasing proportion and ongoing spread of antibiotic-resistant pathogens have further debilitated the condition in battlefield against the UTIs. Lack of estrogen may contribute to high inclination of UTIs after menopause and hormone replacement therapy can mitigate symptoms of hot flashes, vaginal dryness and UTIs, rationalizing the usage of estrogen and analogues in treatment and prophylaxis of UTIs.

Laser contacting of hairpin windings in electrical vehicle motors using ring-mode laser beams based on angularly-uniform Lissajous trajectories.

The contacting process of hairpin windings is deemed the most important and challenging process in manufacturing electric vehicle motors. This paper proposes a ring-mode laser contacting method for copper hairpin windings based on Lissajous-shaped cyclic scanning with a uniform angular speed. Two key variables, trajectory cycle n and angular multiplier k, which represent the laser energy input and distribution respectively, were investigated via single-factor experiments.

Penetration State Recognition during Laser Welding Process Control Based on Two-Stage Temporal Convolutional Networks.

Vision-based laser penetration control has become an important research area in the field of welding quality control. Due to the complexity and large number of parameters in the monitoring model, control of the welding process based on deep learning and the reliance on long-term information for penetration identification are challenges. In this study, a penetration recognition method based on a two-stage temporal convolutional network is proposed to realize the online process control of laser welding.

Berberine hydrochloride alleviates chronic prostatitis/chronic pelvic pain syndrome by modifying gut microbiome signaling.

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is highly prevalent worldwide and poses a significant threat to men's health, particularly affecting young men. However, the exact causes and mechanisms behind CP/CPPS remain unclear, leading to challenges in its treatment. In this research, a CP/CPPS rat model was established with complete Freund's adjuvant (CFA), and berberine hydrochloride was administered through daily gavage to assess its therapeutic effects.

Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment.

The perplexing issues related to positive surgical margins and the considerable negative consequences associated with systemic chemotherapy have posed ongoing challenges for clinicians, especially when it comes to addressing bladder cancer treatment. The current investigation describes the production of nanocomposites loaded with gemcitabine (GEM) and cisplatin (CDDP) through the utilization of electrospinning technology. In vitro and in vivo studies have provided evidence of the strong effectiveness in suppressing tumor advancement while simultaneously reducing the accumulation of chemotherapy drugs within liver and kidney tissues.

Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.

Increasing evidence suggests that autophagy plays a major role during renal fibrosis. Transcription factor EB (TFEB) is a critical regulator of autophagy- and lysosome-related gene transcription. However, the pathophysiological roles of TFEB in renal fibrosis and fine-tuned mechanisms by which TFEB regulates fibrosis remain largely unknown.

Analysis of risk factors affecting the postoperative drainage after a laparoscopic partial nephrectomy: a retrospective study.

Purpose: Laparoscopic partial nephrectomy (LPN) remains the most commonly used measure for treating localized renal cell cancer (RCC) with an increasing incidence of RCC ever since the 1990s. This study aimed to identify risk factors that affect the postoperative time of drainage and total drainage volume after LPN.

Method: The clinical data of 612 RCC patients who received LPN from January 2012 to December 2022 in our hospital, including the postoperative drainage time and total drainage volume, were retrospectively analyzed.

Frailty as a risk marker of adverse lower urinary symptom outcomes in patients with benign prostatic hyperplasia undergoing transurethral resection of prostate.

Purpose: Lower urinary symptoms (LUTS) may persist in a proportion of patients with benign prostatic hyperplasia (BPH) following transurethral resection of prostate (TURP), which is a major cause of reduced quality-of-life. We aimed to investigate the effect of frailty on LUTS in patients with BPH treated with TURP.

Methods: We longitudinally evaluated LUTS and health-related quality-of-life (HRQOL) in patients with BPH treated with TURP from February 2019 and January 2022 using International Prostate Symptom Score (IPSS) and Short Form-8 (SF-8), respectively.

Qualification of Necroptosis-Related lncRNA to Forecast the Treatment Outcome, Immune Response, and Therapeutic Effect of Kidney Renal Clear Cell Carcinoma.

Background: Kidney renal clear cell carcinoma (KIRC) is considered as a highly immune infiltrative tumor. Necroptosis is an inflammatory programmed cell death associated with a wide range of diseases. Long noncoding RNAs (lncRNAs) play important roles in gene regulation and immune function.

A Multilayer Nanofibrous Mat for the Topical Chemotherapy of the Positive Margin in Bladder Cancer.

Treatment of positive margins after solid tumor resection remains a significant challenge for clinicians. Owing to unique structural features, electrospun nanofibrous mats are promised to be an implantable antitumor system through the delivery of active agents in a controlled manner. In this study, we utilized sequential electrospinning to fabricate a multilayer mat in which gemcitabine (GEM) and cisplatin (CDDP) were electrospun individually in distinct layers.

Development of a Laser Scanning Machining System Supporting On-the-Fly Machining and Laser Power Follow-Up Adjustment.

In this study, a laser scanning machining system supporting on-the-fly machining and laser power follow-up adjustment was developed to address the increasing demands for high-speed, wide-area, and high-quality laser scanning machining. The developed laser scanning machining system is based on the two-master and multi-slave architecture with synchronization mechanism, and realizes the integrated and synchronous collaborative control of the motion stage or robot, the galvanometer scanner, and the laser over standard industrial ethernet networks. The galvanometer scanner can be connected to the industrial ethernet topology as a node, via the self-developed galvanometer scanner control gateway module, and a "one-transmission and multiple-conversion" approach is proposed to ensure real-time ability and synchronization.

Clinicopathological factors associated with pathological upgrading from biopsy to prostatectomy in patients with ISUP grade group ≤2 prostate cancer.

We performed this study to investigate pathological upgrading from biopsy to prostatectomy and clinicopathological factors associated with grade group (GG) upgrading in patients with International Society of Urological Pathology (ISUP) GG 1 and 2 prostate cancer (PCa) in a Chinese cohort. We included patients diagnosed with PCa with ISUP GG 1 and 2 at biopsy, who underwent RP at our institution. Pre- and postoperative clinical variables were examined.

Penetration Depth Prediction of Infinity Shaped Laser Scanning Welding Based on Latin Hypercube Sampling and the Neuroevolution of Augmenting Topologies.

This paper builds an infinity shaped ("∞"-shaped) laser scanning welding test platform based on a self-developed motion controller and galvanometer scanner control gateway, takes the autogenous bead-on-plate welding of 304SS with 3 mm thick specimens as the experimental objects, designs the experimental parameters by the Latin hypercube sampling method for obtaining different penetration depth welded joints, and presents a methodology based on the neuroevolution of augmenting topologies for predicting the penetration depth of "∞"-shaped laser scanning welding. Laser power, welding speed, scanning frequency, and scanning amplitude are set as the input parameters of the model, and welding depth (WD) as the output parameter of the model. The model can accurately reflect the nonlinear relationship between the main welding parameters and WD by validation.

Standardized Incidence Rate, Risk and Survival Outcomes of Second Primary Malignancy Among Renal Cell Carcinoma Survivors: A Nested Case-Control Study.

Purpose: Second primary malignancy (SPM) is challenging for treatment and long-term survival. We sought to investigate the standardized incidence rate (SIR), risk factors, and survival outcomes for SPM after renal cell carcinoma (RCC) treatment.

Method: A nested case-control study was designed, we identified all T1-4N0-1M0 RCC patients diagnosed between 2004 and 2015 in the Surveillance, Epidemiology, and End Results database and followed them for SPM diagnosis for up to 13 years.