Monitoring water quality through efficient quantification of water quality parameters (WQPs) is of paramount importance to environmental management of urban rivers. Unmanned aerial vehicle (UAV) remote sensing techniques posed a great opportunity for visualizing spatial distributions of WQPs concentrations with higher flexibility and monitoring frequency compared to satellite remote sensing techniques, assisting to trace potential contamination sources and prevent water quality from degradation. However, current methods of water quality monitoring usually involved large masses of water samples as training data to keep calculation accuracy every time their study area changed, increasing financial cost and incurring time delay in monitoring and evaluating water quality.
View Article and Find Full Text PDFObjective: The primary objective of this study was to scrutinise the disparities in the diversity, structure, and function of the oral microbiome among caries-free children from the Zhuang and Han ethnic groups with a focus on the influence of ethnically distinct oral health behaviours on the composition of the oral microbiota.
Methods: A questionnaire survey was conducted to assess oral health behaviours and dental plaque samples were collected from 96 Zhuang and Han children aged 4-5 years living in Guangxi, southern China for high-throughput sequencing. PCR amplification was performed for sequencing of the V4 region of the 16S rDNA gene, and second-generation sequencing was performed using the Illumina MiSeq platform to compare and analyse the diversity, structure and function of the microbiota.
Objectives: Signet ring cell carcinoma (SRCC) of the urinary bladder is a rare and highly aggressive form of bladder cancer, with no widely agreed-upon treatment strategy. The aim of this study was to identify important factors influencing patient prognosis and to assess how various treatment approaches affect survival outcomes.
Methods: A retrospective study was conducted using data from the Surveillance, Epidemiology, and End Results (SEER) Program, including patients with bladder primary SRCC who were presented between 2000 and 2017.
Comprehensive and effective water quality monitoring is vital to water environment management and prevention of water quality from degradation. Unmanned aerial vehicle (UAV) remote sensing techniques have gradually matured and prevailed in monitoring water quality of urban rivers, posing great opportunity for more effective and flexible quantitative estimation of water quality parameter (WQP) than satellite remote sensing techniques. However, current UAV remote sensing methods often entail large quantities of cost-prohibitive in-situ collected training samples with corresponding chemical analysis in different monitoring watersheds, laying time and fiscal pressure on local environmental protection department.
View Article and Find Full Text PDFBackground: Fungal skin diseases are the most common and widespread fungal infections, exerting a significant impact on patients' socio-psychological health and the quality of life.
Objectives: To assess and compare the global burden of fungal skin diseases in 2019 and over the past 30 years.
Methods: Data were retrieved from the Global Burden of Disease Study 2019.
Synthesis of conjugated compounds with unusual shape-persistent structures remains a challenge. Herein, utilizing thermodynamically reversible intermolecular Friedel-Crafts alkylation, a dynamic covalent chemistry (DCC) reaction, we facilely synthesized a figure-eight shaped macrocycle FEM and cage molecules CATPA/CACz. X-ray crystallographic analysis confirmed the chemical geometries of tetracation FEM(PF ) and hexacation CACz(SbF ).
View Article and Find Full Text PDFGraphene and its derivatives have attracted much attention as nanomaterials in bone tissue engineering because of their remarkable ability to induce cell osteogenic differentiation. However, graphene quantum dots (GQDs), as graphene derivatives, little is known about their osteodifferentiation- and osteoinduction-promoting capabilities, especially in the restoration of bone defect caused by periodontitis. Therefore, there is a growing need to investigate the effect of GQDs on periodontal ligament stem cells (PDLSCs).
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
October 2023
Purpose: Recent studies have revealed that primary tumor resection (PTR) surgery could improve prognosis in some solid tumors. Thus, we aimed to investigate whether patients with stage IVB cervical carcinoma can benefit from PTR surgery and who can benefit.
Methods: We extracted and obtained data on patients with stage IVB cervical carcinoma from the SEER database from 2010 to 2017 and classified them into two groups: the surgery and the non-surgery group.
Quantitative prediction by unmanned aerial vehicle (UAV) remote sensing on water quality parameters (WQPs) including phosphorus, nitrogen, chemical oxygen demand (COD), biochemical oxygen demand (BOD), and chlorophyll a (Chl-a), total suspended solids (TSS), and turbidity provides a flexible and effective approach to monitor the variation in water quality. In this study, a deep learning-based method integrating graph convolution network (GCN), gravity model variant, and dual feedback machine involving parametric probability analysis and spatial distribution pattern analysis, named Graph Convolution Network with Superposition of Multi-point Effect (SMPE-GCN) has been developed to calculate concentrations of WQPs through UAV hyperspectral reflectance data on large scale efficiently. With an end-to-end structure, our proposed method has been applied to assisting environmental protection department to trace potential pollution sources in real time.
View Article and Find Full Text PDFPurpose: To clarify the necessity and effect of a single intraoperative instillation of chemotherapy during radical cystectomy.
Methods: Patients who underwent radical cystectomy for bladder cancer between January 2013 and April 2019 were retrospectively evaluated and divided into a non-instillation group and an instillation group according to the intraoperative instillation of chemotherapy. Univariate and multivariate Cox regression was used to determine the clinical predictors of overall survival and disease-free survival.
Sepsis is a leading cause of fatality in invasive candidiasis. The magnitude of the inflammatory response is a determinant of sepsis outcomes, and inflammatory cytokine imbalances are central to the pathophysiological processes. We previously demonstrated that a FF-ATP synthase α subunit deletion mutant was nonlethal to mice.
View Article and Find Full Text PDFFusarium head blight (FHB), predominantly caused by is one of the most economically important fungal diseases of small-grain cereals. Since the early 1990s, FHB has been a devastating wheat disease in parts of Canada and the United States, causing significant economic impacts on the cereal grain industry through reduced seed quality and yield, and grain contamination with fungal toxins (Brar et al. 2019).
View Article and Find Full Text PDFInt J Environ Res Public Health
October 2022
Epidemics represent a threat to human life and economy. Meanwhile, medical and non-medical approaches to fight against them may result in additional economic shocks. In this paper, we examine the economic impact of the 2003 SARS outbreak in China and associated government policies.
View Article and Find Full Text PDF(1) Purpose: The purpose of this study was to evaluate the prognostic capacity of the pathological N status (pN), lymph node ratio (LNR), and the log odds of positive lymph nodes (LODDS), and to build a prognostic nomogram to predict overall survival (OS) for bladder cancer patients treated by radical cystectomy. (2) Methods: The clinical and pathological characteristics of 10,938 patients with bladder cancer were identified from the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2017. The predictive capacity was assessed by univariate and multivariate Cox regression analyses, the area under the receiver operating characteristic curve (AUC), and C-index.
View Article and Find Full Text PDFThe study aims to investigate and compare the success rate of concentrated growth factor (CGF) and blood clot (BC) as scaffolds in regenerative endodontic procedures (REPs). Immature permanent necrotic teeth treated by REPs with at least a 6-month follow-up were included. These teeth were divided into the CGF (53 teeth) and BC (68 teeth) groups.
View Article and Find Full Text PDFPurpose: To evaluate urinary outcomes of pelvic construction and lateral capsule sparing techniques in robot-assisted radical cystectomy with orthotopic ileal neobladder (RARC-OIN).
Methods: A total of 107 male patients who underwent RARC-OIN during January 2017 and February 2021 in Sun Yat-sen Memorial Hospital were analyzed retrospectively. Standard RARC-OIN with or without nerve sparing technique was performed in 44 patients (standard group), lateral prostate capsule sparing technique was performed in 20 patients (LCS group), combined pelvic reconstruction (CPR) technique including anterior suspension and posterior reconstruction were performed in 43 patients (CPR group).
Objective: The purpose of this study was to investigate associations between alveolar bone height changes on the labial and lingual sides in mandibular incisors and three-dimensional orthodontic tooth movement, involving apex displacement, tooth inclination, and angulation.
Materials And Methods: The samples consisted of 43 adult patients treated with Invisalign aligners. All subjects were skeletal Class I patients without extraction in mandible.
Objective: Conventional survival analysis plays a limited role in patients who have survived a period after initial treatment. The present study analyzed how conditional survival (CS) predicted survival rate over time for nonmetastatic muscle-invasive bladder cancer (MIBC) patients after trimodal treatment.
Method: This retrospective study from the SEER database included consecutive patients with nonmetastatic MIBC who received trimodal therapy (TMT) between January 2010 and December 2017.
Background: Currently, the progress of targeted drugs in the treatment of metastatic clear cell renal cell carcinoma (mccRCC) is limited. Cytoreductive nephrectomy (CN), as an alternative treatment, can improve the prognosis of patients with metastatic renal cell carcinoma to some extent. However, it is unclear which patients would benefit from this tumor reduction operation.
View Article and Find Full Text PDFTo understand the prevalence, coinfection with other viruses, underlying genetic evolution, recombination, and molecular biological characteristics of goose circovirus (GoCV) in Guangdong, China, from December 2019 to August 2020, 310 tissue samples of geese showing stunted growth and feather disorder syndrome were collected from this region and analyzed. GoCV, Tembusu virus, waterfowl paramyxovirus, avian influenza virus, fowl adenovirus type 4, and duck plague virus were detected with PCR or real-time PCR. Thirty-one complete GoCV viral genomes were obtained from 164 PCR-verified GoCV nucleotide-positive samples and subjected to phylogenetic analysis, gene recombination analysis, and genome secondary structure prediction.
View Article and Find Full Text PDFIntroduction: Sunitinib is the first-line targeted drug for the treatment of advanced renal cell carcinoma (RCC), but its therapeutic potential is limited by premature drug resistance. In an attempt to overcome this limitation, a sunitinib-resistant cell-derived xenograft (CDX) model of clear cell renal cell carcinoma (ccRCC) in vivo was constructed in this study. The molecular mechanism of drug resistance was analyzed using sequencing and bioinformatics tools.
View Article and Find Full Text PDFCircular RNAs (circRNAs) are a type of covalently closed circular-formed RNAs and play crucial roles in the oncogenesis and progression of various human cancers. Here we identified a novel circRNA, circPPP6R3, to be highly expressed both in clear cell renal cell carcinoma (ccRCC) tissues and cell lines based on analyzing high-throughput sequencing data and qRT-PCR analysis. Highly expressed circPPP6R3 was positively correlated with higher histological grade, T stage, and M stage as well as advanced clinical stage of ccRCC patients.
View Article and Find Full Text PDFObjective: M2 macrophages are associated with a poor prognosis in a variety of malignancies. There are, however, few relevant investigations in clear cell renal cell carcinoma (ccRCC).
Methods: The expression of M2 macrophages in ccRCC tissues was first discovered using immunohistochemistry in this study.
Mol Plant Microbe Interact
March 2022
Most plant fungal pathogens that cause worldwide crop losses are understudied, due to various technical challenges. With the increasing availability of sequenced whole genomes of these non-model fungi, effective genetic analysis methods are highly desirable. Here, we describe a newly developed pipeline, which combines forward genetic screening with high-throughput next-generation sequencing to enable quick gene discovery.
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