γ-Oryzanol: A nutrient-rich ingredient for promoting wound healing.

γ-Oryzanol (Orz) is a powerful antioxidant found in rice bran and oil, known for its numerous health benefits. Nevertheless, its precise impact on skin wound healing remains largely unexplored. This research focuses on comprehensively examining the ability of Orz to promote tissue repair through laboratory-based and animal model experiments.

Integrating retrieval-augmented generation for enhanced personalized physician recommendations in web-based medical services: model development study.

Background: Web-based medical services have significantly improved access to healthcare by enabling remote consultations, streamlining scheduling, and improving access to medical information. However, providing personalized physician recommendations remains a challenge, often relying on manual triage by schedulers, which can be limited by scalability and availability.

Objective: This study aimed to develop and validate a Retrieval-Augmented Generation-Based Physician Recommendation (RAGPR) model for better triage performance.

Polyphenolic Hispolon Derived from Medicinal Mushrooms of the and Genera Promotes Wound Healing in Hyperglycemia-Induced Impairments.

: This study investigated the wound-healing potential of hispolon, a polyphenolic pigment derived from medicinal mushrooms, under diabetic conditions using both in vitro and in vivo models. : In the in vitro assays, L929 fibroblast cells exposed to high glucose (33 mmol/L) were treated with hispolon at concentrations of 2.5, 5, 7.

Anticancer potentials of chaga and notoginseng against dog bladder cancer organoids.

Muscle-invasive bladder cancer (MIBC) is a common form of BC in dogs. Adjuvant chemotherapy administration is commonly applied in MIBC cases, but patients sometimes experience treatment failure and recurrence. Therefore, supplements with anticancer properties, such as traditional Chinese medicines (TCMs), are required, and they have been widely used in Japanese human medicine and may be useful in veterinary medicine.

Mechanistic study of the calcination process in magnesium production: Application of the Darcy-Clausius coupling model for improving environmental efficiency.

In the process of industrialization, it is found that the calcination process is an important factor affecting the reduction rate, which determines the energy consumption and carbon emission of the reaction process. In this study, the micro-nano physical model of the factors affecting the reduction rate of calcined precursors was constructed by coloring the SEM results of pellets before and after calcination with Gaussian height expression and combining Clausius and Gibbs equations. The influence of the formation degree of the internal pores of the pellets on the reduction rate was analyzed by controlling the calcination time of the precursor.

Dilong (Earthworm) alleviates cyclophosphamide-induced brain injury by reducing mitochondrial damage in neuronal cells.

The experiment was designed to explore the effects and mechanism of Dilong on alleviating cyclophosphamide (CTX)-induced brain injury in mice. Fifty male SPF Kunming mice aged 6-8 weeks were randomly divided into five groups: Group A served as the control group; Group B received intraperitoneal injection of CTX; Groups C, D, and E were administered Dilong at doses of 100, 200, and 400 mg/kg respectively for 14 days after intraperitoneal injection of CTX. Results showed that after modeling, the movement speed of mice significantly decreased (P < 0.

Salinomycin induces apoptosis and potentiates the antitumor effect of doxorubicin against feline mammary tumor 2.5D organoids.

Feline mammary tumors (FMT) are the third most common form of neoplasm in cats. The prognosis of FMT is poor due to its high malignancy and metastatic potential. The outcomes of treatment using the common anticancer drug doxorubicin (DOX) are unsatisfactory, with resistance inevitably leading to treatment failure and disease recurrence.

Astragaloside IV alleviates heatstroke brain injury and neuroinflammation in male mice by regulating microglial polarization via the PI3K/Akt signaling pathway.

Heatstroke is a condition caused by overheating of the body that leads to severe central nervous system dysfunction. Although there have been numerous studies on the pathological process of heatstroke, effective treatment methods are lacking. Astragaloside IV can protect the brain from inflammation and brain damage in various inflammation-related diseases, but it has not yet been used clinically for the treatment of heatstroke.

Clinical characteristics and risk factors of severe COVID-19 in hospitalized neonates with omicron variant infection: a retrospective study.

Background: Reports on coronavirus disease 2019 (COVID-19) in neonates are limited, especially in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) Omicron variant. This study aims to analyze the clinical characteristics and identify risk factors associated with severe COVID-19 in neonates infected with Omicron variant.

Methods: The study population was represented by neonates with COVID-19, who were admitted to The Affiliated Children's Hospital of Xi'an Jiaotong University in northwest China, from December 10, 2022 to January 20, 2023.

TruckSim-based study of the rollover accident mechanisms of container semitrailers on freeway interchange loop ramps.

In this study, to investigate the factors affecting container semitrailer rollovers while driving on interchange loop ramps, a simulation model was established in TruckSim on the basis of data collected from an in-depth investigation of the vehicle, road, and driving behaviors in a real accident. The established model was validated by reproducing the accident in a simulation. The effects of vehicle speed, the height of the cargo's center of gravity, tractor-semitrailer interactions, and the radius of the circular curve on container semitrailer rollover were investigated using the established model.

PRMT6 Epigenetically Drives Metabolic Switch from Fatty Acid Oxidation toward Glycolysis and Promotes Osteoclast Differentiation During Osteoporosis.

Epigenetic regulation of metabolism profoundly influences cell fate commitment. During osteoclast differentiation, the activation of RANK signaling is accompanied by metabolic reprogramming, but the epigenetic mechanisms by which RANK signaling induces this reprogramming remain elusive. By transcriptional sequence and ATAC analysis, this study identifies that activation of RANK signaling upregulates PRMT6 by epigenetic modification, triggering a metabolic switching from fatty acids oxidation toward glycolysis.

Occurrence and Flow Behavior for Oil Transport in Mixed Wetting Nanoscale Shale Bedding Fractures.

Shale reservoirs are characterized by an abundance of nanoscale porosities and microfractures. The states of fluid occurrence and flow behaviors within nanoconfined spaces necessitate novel research approaches, as traditional percolation mathematical models are inadequate for accurately depicting these phenomena. This study takes the Gulong shale reservoir in China as the subject of its research.

Investigation of the Shared Biomarkers in Heterotopic Ossification Between Ossification of the Ligamentum Flavum and Ankylosing Spondylitis.

Study Design: Bioinformatics analysis of Gene Expression Omnibus (GEO).

Objective: Ossification of the ligamentum flavum (OLF) and ankylosing spondylitis (AS) represent intricate conditions marked by the gradual progression of endochondral ossification. This investigation endeavors to unveil common biomarkers associated with heterotopic ossification and explore the potential molecular regulatory mechanisms.

The erosive effect of pomegranate juice on enamel: An in vitro study.

Aim: Dental erosion is a chemical-mechanical process that leads to the loss of dental hard tissues. This study aimed to investigate the effect of pomegranate juice on the enamel.

Methods: Enamel blocks were randomly divided into three groups: deionized water, cola, and pomegranate juice.

Correlation between PD-1/PD-L1 and RANKL/OPG in chronic apical periodontitis model of Sprague-Dawley rats.

Chronic apical periodontitis (CAP) is characterized by inflammation and destruction of the apical periodontium that is of pulpal origin, appearing as an apical radiolucent area, and does not produce clinical symptoms. Little is known about whether the PD-1/PD-L1 ratio is associated with the balance between RANKL and OPG in CAP. The relationship between PD-1/PD-L1 and RANKL/OPG in CAP is investigated in this study.