Publications by authors named "Yishan Liu"

γ-Oryzanol (Orz) is a powerful antioxidant found in rice bran and oil, known for its numerous health benefits. Nevertheless, its precise impact on skin wound healing remains largely unexplored. This research focuses on comprehensively examining the ability of Orz to promote tissue repair through laboratory-based and animal model experiments.

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Background: Web-based medical services have significantly improved access to healthcare by enabling remote consultations, streamlining scheduling, and improving access to medical information. However, providing personalized physician recommendations remains a challenge, often relying on manual triage by schedulers, which can be limited by scalability and availability.

Objective: This study aimed to develop and validate a Retrieval-Augmented Generation-Based Physician Recommendation (RAGPR) model for better triage performance.

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: This study investigated the wound-healing potential of hispolon, a polyphenolic pigment derived from medicinal mushrooms, under diabetic conditions using both in vitro and in vivo models. : In the in vitro assays, L929 fibroblast cells exposed to high glucose (33 mmol/L) were treated with hispolon at concentrations of 2.5, 5, 7.

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Muscle-invasive bladder cancer (MIBC) is a common form of BC in dogs. Adjuvant chemotherapy administration is commonly applied in MIBC cases, but patients sometimes experience treatment failure and recurrence. Therefore, supplements with anticancer properties, such as traditional Chinese medicines (TCMs), are required, and they have been widely used in Japanese human medicine and may be useful in veterinary medicine.

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In the process of industrialization, it is found that the calcination process is an important factor affecting the reduction rate, which determines the energy consumption and carbon emission of the reaction process. In this study, the micro-nano physical model of the factors affecting the reduction rate of calcined precursors was constructed by coloring the SEM results of pellets before and after calcination with Gaussian height expression and combining Clausius and Gibbs equations. The influence of the formation degree of the internal pores of the pellets on the reduction rate was analyzed by controlling the calcination time of the precursor.

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The experiment was designed to explore the effects and mechanism of Dilong on alleviating cyclophosphamide (CTX)-induced brain injury in mice. Fifty male SPF Kunming mice aged 6-8 weeks were randomly divided into five groups: Group A served as the control group; Group B received intraperitoneal injection of CTX; Groups C, D, and E were administered Dilong at doses of 100, 200, and 400 mg/kg respectively for 14 days after intraperitoneal injection of CTX. Results showed that after modeling, the movement speed of mice significantly decreased (P < 0.

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  • Exertional heatstroke (EHS) can cause serious harm to the heart and other organs, highlighting the need for effective treatment strategies.
  • This study focused on the impact of L-carnitine (LC) in protecting against cardiac damage and dysfunction caused by EHS in rats, revealing that LC significantly improves heart health by reducing cell death and harmful changes in heart tissue.
  • The protective effects of LC are linked to its ability to inhibit the PERK pathway, which is involved in stress responses in cells, suggesting that LC supplementation may be a promising approach to mitigate heart injury in EHS cases.
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  • * The study examined a large population in Sweden, comparing medication usage in parents of children with cancer to those with cancer-free children over an 8-year period.
  • * Education levels impacted medication use, indicating a need for targeted support and intervention for parents dealing with the stress of a child's cancer diagnosis.
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  • The study explores the mechanical principles of external fixation and resistance training for wrist rehabilitation after a distal radius fracture (DRF).
  • It proposes two wearable exoskeleton devices: an adjustable fixation device (AFD) for early-stage protection and mobilization, and a resistance training device (RTD) for later-stage muscle recovery.
  • Experimental tests indicate that the AFD effectively monitors joint angles and the RTD enhances muscle strength, supporting active rehabilitation for DRF patients.
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Feline mammary tumors (FMT) are the third most common form of neoplasm in cats. The prognosis of FMT is poor due to its high malignancy and metastatic potential. The outcomes of treatment using the common anticancer drug doxorubicin (DOX) are unsatisfactory, with resistance inevitably leading to treatment failure and disease recurrence.

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Heatstroke is a condition caused by overheating of the body that leads to severe central nervous system dysfunction. Although there have been numerous studies on the pathological process of heatstroke, effective treatment methods are lacking. Astragaloside IV can protect the brain from inflammation and brain damage in various inflammation-related diseases, but it has not yet been used clinically for the treatment of heatstroke.

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  • Hispidin, a substance found in certain mushrooms, could help in healing wounds and has important medical uses.
  • Researchers tested hispidin on cells and rats to see how well it helps wounds heal and fights germs.
  • The studies showed that hispidin helps wounds close faster, boosts healing, and is safe to use at high amounts without causing harm.
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Background: Reports on coronavirus disease 2019 (COVID-19) in neonates are limited, especially in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) Omicron variant. This study aims to analyze the clinical characteristics and identify risk factors associated with severe COVID-19 in neonates infected with Omicron variant.

Methods: The study population was represented by neonates with COVID-19, who were admitted to The Affiliated Children's Hospital of Xi'an Jiaotong University in northwest China, from December 10, 2022 to January 20, 2023.

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In this study, to investigate the factors affecting container semitrailer rollovers while driving on interchange loop ramps, a simulation model was established in TruckSim on the basis of data collected from an in-depth investigation of the vehicle, road, and driving behaviors in a real accident. The established model was validated by reproducing the accident in a simulation. The effects of vehicle speed, the height of the cargo's center of gravity, tractor-semitrailer interactions, and the radius of the circular curve on container semitrailer rollover were investigated using the established model.

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  • A significant rise in diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) mortality was observed during the COVID-19 pandemic, prompting an examination of death trends from 2006 to 2021.
  • Analysis revealed DKA-related deaths increased notably during the pandemic years, with over half of these excess deaths linked to COVID-19, while HHS also saw a sharp rise in excess deaths despite a decline prior to the pandemic.
  • The study highlighted concerning disparities, with higher mortality rates among pediatric patients and females, indicating an urgent need for targeted health strategies to address the risks faced by these populations in future public health emergencies.
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Epigenetic regulation of metabolism profoundly influences cell fate commitment. During osteoclast differentiation, the activation of RANK signaling is accompanied by metabolic reprogramming, but the epigenetic mechanisms by which RANK signaling induces this reprogramming remain elusive. By transcriptional sequence and ATAC analysis, this study identifies that activation of RANK signaling upregulates PRMT6 by epigenetic modification, triggering a metabolic switching from fatty acids oxidation toward glycolysis.

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  • The study aimed to evaluate the effectiveness and tolerability of direct-acting antiviral (DAA) treatments for hepatitis C virus (HCV) across different genotypes (GTs) in a global, real-world context, focusing particularly on GT3 and GT6.
  • Researchers analyzed data from 15,849 chronic hepatitis C patients across Asia, North America, and Europe over a seven-year period, noting demographic factors such as age, sex, and prior treatment history.
  • Results showed a high sustained virological response (SVR12) rate of 96.9% overall, with variances by genotype, highlighting that independent factors like advanced age, cirrhosis, and previous treatment failures affected treatment outcomes, while being
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  • The alumina industry faces challenges due to the depletion of high-grade bauxite, leading to the exploration of high-sulfur bauxite as a viable alternative that requires effective desulfurization methods.
  • The paper reviews both pre-treatment methods (like roasting, flotation, biological, and electrochemical techniques) and post-treatment methods to address the sulfur content in bauxite, which can adversely affect product quality and equipment during processing.
  • It emphasizes the need for developing cost-effective and eco-friendly desulfurization strategies by combining various methods, and discusses the future potential for utilizing high-sulfur bauxite resources.
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  • The study examined postpartum depression (PPD) prevalence among women living with HIV (WLHIV) in Botswana using the Edinburgh Postnatal Depression Scale (EPDS), involving 300 WLHIV and 131 HIV-uninfected women.
  • It found that 8% of WLHIV experienced PPD symptoms at various postpartum follow-ups, which was slightly higher than the 6.9% in HIV-uninfected women, but no significant link was found between HIV status and PPD.
  • However, WLHIV on efavirenz-based antiretroviral therapy (ART) had higher odds of PPD compared to those on dolutegravir-based ART, indicating a possible connection between type of ART and PPD symptoms
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Shale reservoirs are characterized by an abundance of nanoscale porosities and microfractures. The states of fluid occurrence and flow behaviors within nanoconfined spaces necessitate novel research approaches, as traditional percolation mathematical models are inadequate for accurately depicting these phenomena. This study takes the Gulong shale reservoir in China as the subject of its research.

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  • The study analyzed TB-related deaths from 2006 to 2021 to understand the impact of the COVID-19 pandemic on mortality rates.
  • There were 18,628 TB-related deaths recorded, with significant increases in mortality rates during the pandemic, particularly among females aged 45-64.
  • The findings indicate that COVID-19 reversed the previous decline in TB-related deaths in the U.S., disproportionately affecting women.
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Study Design: Bioinformatics analysis of Gene Expression Omnibus (GEO).

Objective: Ossification of the ligamentum flavum (OLF) and ankylosing spondylitis (AS) represent intricate conditions marked by the gradual progression of endochondral ossification. This investigation endeavors to unveil common biomarkers associated with heterotopic ossification and explore the potential molecular regulatory mechanisms.

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Aim: Dental erosion is a chemical-mechanical process that leads to the loss of dental hard tissues. This study aimed to investigate the effect of pomegranate juice on the enamel.

Methods: Enamel blocks were randomly divided into three groups: deionized water, cola, and pomegranate juice.

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Chronic apical periodontitis (CAP) is characterized by inflammation and destruction of the apical periodontium that is of pulpal origin, appearing as an apical radiolucent area, and does not produce clinical symptoms. Little is known about whether the PD-1/PD-L1 ratio is associated with the balance between RANKL and OPG in CAP. The relationship between PD-1/PD-L1 and RANKL/OPG in CAP is investigated in this study.

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  • * Of the 50 enrolled patients, 40% achieved a pathological complete response, and tumor regression was observed in varying degrees among others, highlighting the potential benefits of this combined treatment approach.
  • * Treatment-related side effects were noted in over half of the patients, primarily mild to moderate, suggesting that the combination therapy is not only effective but also generally well-tolerated, warranting further research in larger studies.
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