Circular RNA SET domain protein 3 promotes nasopharyngeal carcinoma proliferation, cisplatin resistance, and protein kinase B / mammalian target of rapamycin pathway activation by modulating microRNA-147a expression.

Circular RNA (circRNA) plays a crucial role in the establishment and progression of nasopharyngeal carcinoma (NPC). Understanding the role of circRNA in NPC is helpful to find new therapeutic targets for NPC. The purpose of this study was to explore the effects of circRNA SET domain protein 3 (circSETD3) on protein kinase B (Akt)/ mammalian target of rapamycin (mTOR) signaling pathway and cisplatin (DDP) resistance to NPC and explore its downstream mechanism.

Expression of endothelin-1 in laryngocarcinoma tissues and its clinical significance.

In recent years, the incidence of laryngeal carcinoma has been on the increase. The aim of the present study was to examine the expression level of endothelin-1 (ET-1) in laryngeal carcinoma tissues and to establish its clinical significance. A total of 82 cases of laryngeal carcinoma tissues were examined, of which 27 cases were stage I, 34 were stage II, and 21 were stage III.

[Part of the vertebral artery in patients with sudden deafness].

Objective: To explore the characteristics of vertebral artery system in the patients with sudden deafness by using digital subtraction angiography (DSA).

Method: Thirty-four cases of sudden deafness with vertebrobasilar artery ischemia confirmed by the color doppler ultrasound were undergone DSA in both side. The characteristics of vertebral artery, basal artery and before-cerebellum artery were analysis before specific therapy.