Malvidin From Ameliorates Allergic Responses in Ovalbumin-Induced Allergic Rhinitis Mouse Model via the STAT6/GATA3 Pathway.

Background: L. (commonly known as mallow) has been widely used in traditional Tibetan formulations to treat allergic rhinitis (AR), and malvidin is a key anti-inflammation constituent of this plant.

Objective: The present study aimed to evaluate the potential therapeutic effect and mechanism of malvidin in an AR mouse model.

The oxidant-antioxidant imbalance was involved in the pathogenesis of chronic rhinosinusitis with nasal polyps.

Background: Although oxidative stress is involved in the pathophysiological process of chronic rhinosinusitis with nasal polyps (CRSwNP), the specific underlying mechanism is still unclear. Whether antioxidant therapy can treat CRSwNP needs further investigation.

Methods: Immunohistochemistry, immunofluorescence, western blotting and quantitative polymerase chain reaction (qPCR) analyses were performed to detect the distribution and expression of oxidants and antioxidants in nasal polyp tissues.

Ruthenium(II)-Catalyzed [4 + 2] Electro-Oxidative Annulation of -Arylpurines/Purine Nucleosides.

A sustainable pathway for the synthesis of tetracyclic purinium salts via ruthenium-catalyzed electro-oxidative annulation of -arylpurine nucleosides with alkynes without a stoichiometric metal oxidant has been developed. The protocol described herein exhibits high regioselectivity, broad scope, and wide functional group tolerance, allowing efficient coupling of various biologically important molecules including acyclic, ribosyl, arabinosyl, and deoxyribosyl purine nucleoside derivatives. A novel purinoisoquinolinium-coordinated ruthenium(0) sandwich intermediate has been isolated, crystallographically characterized, and electrochemically analyzed, offering direct mechanistic insight.

Development and Validation of a Chinese Resilience Scale for Young Children.

(1) Background: Resilience research began in the child population as a validity scale to describe children's psychological wellbeing and ability to cope with negative events, and to some extent, to predict recovery and adaptation when they experience adversity again. In view of the important developmental implications of resilience in young children and the lack of a Chinese children's resilience scale, this study developed a resilience scale for young Chinese children based on a systematic review of existing international resilience scales and the characteristics of the Chinese cultural background. (2) Methods: The scale was developed by referring to existing scales, expert interviews, item collation and item finalization, developing original items, then deleting and determining items through item analysis, and finally, comparing with existing scales to obtain the internal and external validity of this scale.

Rhodium(III)-Catalyzed Synthesis of Diverse Fluorescent Polycyclic Purinium Salts from 6-Arylpurine Nucleosides and Alkynes.

Described herein is an efficient strategy for assembling a new library of functionalized polycyclic purinium salts with a wide range of anions through Rh-catalyzed C-H activation/annulation of 6-arylpurine nucleosides with alkynes under mild reaction conditions. The resulting products displayed tunable photoluminescence covering most of the visible spectrum. Mechanistic insights delineated the rhodium catalyst's mode of action.