Enhancing aerobic composting performance of high-salt oily food waste with Bacillus safensis YM1.

To alleviate the inhibitory effects of salt and oil on food waste compost, the compost was inoculated with salt-tolerant and oil-degrading Bacillus safensis YM1. The YM1 inoculation could effectively improve compost maturation index. Compared with uninoculated group, the oil content and Cl concentration in the 0.

Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins.

Ruxolitinib is a cornerstone of management for some subsets of myeloproliferative neoplasms (MPNs); however, a considerable number of patients respond suboptimally. Here, we evaluated the efficacy of micheliolide (MCL), a natural guaianolide sesquiterpene lactone, alone or in combination with ruxolitinib in samples from patients with MPNs, V617F-mutated MPN cell lines, and a V617F knock-in mouse model. MCL effectively suppressed colony formation of hematopoietic progenitors in samples from patients with MPNs and inhibited cell growth and survival of MPN cell lines in vitro.

Case of cryptic rearrangement presenting with myelodysplastic syndrome achieved hematologic and cytogenetic remission with low-dose imatinib plus decitabine therapy.

For a long time, fusion seems to be the only cryptic rearrangement of myeloid/lymphoid neoplasm with tyrosine kinase gene fusions. Recently, with the wide application of RNA sequencing, more cryptic rearrangements of other TK genes have been identified, especially the . Here we report a case of myelodysplastic syndrome with severe thrombocytopenia.

A long-term study on structural changes in calcium aluminate silicate hydrates.

Unlabelled: Production of blended cements in which Portland cement is combined with supplementary cementitious materials (SCM) is an effective strategy for reducing the CO emissions during cement manufacturing and achieving sustainable concrete production. However, the high AlO and SiO contents of SCM change the chemical composition of the main hydration product, calcium aluminate silicate hydrate (C-A-S-H). Herein, spectroscopic and structural data for C-A-S-H gels are reported in a large range of equilibration times from 3 months up to 2 years and Al/Si molar ratios from 0.

mutations accelerate bone marrow fibrosis via EGR1-TNFA axis-mediated neoplastic fibrocyte generation in myeloproliferative neoplasms.

Apart from the central role of the activated JAK/STAT signaling pathway, ASXL1 mutations are the most recurrent additional mutations in myeloproliferative neoplasms and occur much more commonly in myelofibrosis than in essential thrombocythemia and polycythemia vera. However, the mechanism of the association with ASXL1 mutations and bone marrow fibrosis remains unknown. Here, integrating our own data from patients with myeloproliferative neoplasms and a hematopoietic-specific Asxl1 deletion/Jak2V617F mouse model, we show that ASXL1 mutations are associated with advanced myeloproliferative neoplasm phenotypes and onset of myelofibrosis.

Calcite crystallization in the cement system: morphological diversity, growth mechanism and shape evolution.

Carbonation plays an indispensable role in engineering construction, embracing mineralization, CO2 sequestration and low pH induced corrosion, but the essential mechanism of carbonation occurring in calcium silicate hydrate or portlandite can hardly be interpreted. Observation on how carbonation proceeds at the nano scale is thus critical for a better understanding of its dynamics. Here, using electron microscopy combined with first-principles calculation, a new view on carbonation in the cement system is revealed, considering morphological diversity, growth mechanism and shape evolution.

Understanding the deformation mechanism and mechanical characteristics of cementitious mineral analogues from first principles and reactive force field molecular dynamics.

In this paper, first principles and reactive force field molecular dynamics were utilized to study the mechanical properties of tobermorite 9 Å, tobermorite 11 Å and jennite. These are essential minerals in cement chemistry. The mechanical properties calculated by the first-principle method match well with previous experimental results, pointing to the introduction of vdW dispersion-type forces as able to improve the precision.