Publications by authors named "Yiru Tang"
Article Synopsis
- Deficiency in DNA-damage repair (DDR) genes is linked to a higher risk of lung cancer, especially due to rare loss-of-function variants, prompting research into the role of rare regulatory variants.* -
- By analyzing whole-genome sequencing data from nearly 3,000 lung cancer patients and 3,000 controls, researchers identified 750 rare functional regulatory variants (frVars) that affect the transcriptional activity of DDR gene promoters, with a notable increase in these variants among lung cancer cases.* -
- Specifically, down-regulated transcriptional variants (dr-frVars) were significantly associated with lung cancer risk, highlighting the importance of functional regulatory variants in DDR genes, alongside more commonly studied variants, in contributing to
Article Synopsis
- Trichloroethylene (TCE) exposure can lead to a condition called trichloroethylene hypersensitivity syndrome (THS), but the mechanisms behind associated liver injuries remain unclear.
- This study investigated the role of Wnt5a and c-Jun N-terminal kinase (JNK) in liver damage caused by TCE using a sensitization model in mice, revealing that TCE exposure increased Wnt5a/JNK activity in the liver.
- Inhibiting Wnt5a and JNK lessened liver injury by reducing Kupffer cell activation and suppressing inflammatory responses, suggesting potential therapeutic approaches for managing TCE-induced liver damage.
Radical-featured organic materials usually demonstrate significantly narrower bandgap than that of regular organic materials, which is beneficial for near-infrared (NIR) absorption and non-radiative decay process, making them good candidates for photothermal agents (PTAs) of photothermal therapy (PTT). However, most organic radicals are too short-lived to be separated and stable. Herein, a stable pyrylium-croconaine (CR) dye CR845 with high diradical character was synthesized and assembled into CR845 nanoparticles (NPs) to explore the photoacoustic imaging (PAI) and photothermal therapeutic performance under NIR irradiation in vitro and in vivo.
View Article and Find Full Text PDFMutations or loss of function of DJ-1 and Toxoplasma gondii (T. gondii) infection has been linked to neurodegenerative diseases, which are often caused by oxidative stress. However, the relationship between DJ-1 and T.
View Article and Find Full Text PDFFour benzoindolenine-based squaraine dyes (SQs), which have the advantages of intense visible and near-infrared (NIR) absorption and emission ( 663-695 nm, 686-730 nm) were synthesized and characterized by UV-vis absorption, fluorescent emission spectrophotometry, FTIR, NMR and HRMS analysis. Among them, BBSQ showed excellent performance, which exhibited high selectivity to Fe, Cu, and Hg in acetonitrile solution even in the presence of other competitive metal ions, accompanied by obvious color change easily detected by the naked eye. The detection limit was 14.
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