Higher Dietary Inflammatory Index Score is Associated with a Greater Risk of High Allostatic Load in US Adults: National Health and Nutrition Examination Survey, 2017-2020.

Background: Allostatic load (AL) is a comprehensive indicator of chronic stress. Foods with pro-inflammatory properties can increase the risk of elevated AL levels. However, no studies have explored the association between AL and dietary inflammation.

Reduced auditory perception and brain response with quiet TMS coil.

Background: Electromagnetic forces in transcranial magnetic stimulation (TMS) coils generate a loud clicking sound that produces confounding auditory activation and is potentially hazardous to hearing. To reduce this noise while maintaining stimulation efficiency similar to conventional TMS coils, we previously developed a quiet TMS double containment coil (qTMS-DCC).

Objective: To compare the stimulation strength, perceived loudness, and EEG response between qTMS-DCC and a commercial TMS coil.

Research Progress of Deep-Red to Near-Infrared Electroluminescent Materials Based on Organic Cyclometallated Platinum(II) Complexes.

In recent years, the near-infrared (NIR) light-emitting materials have attracted increasing attention due to the broad application prospects in the fields of military industry, aerospace, lighting, display and wearable devices. As the transition metal complexes, platinum(II) complexes have been shown to emit luminescence efficiently in NIR organic light-emitting diodes because of the unique d electron structure. This structure ensures that the platinum(II) complex molecules exhibit a high planarity, variety of excited states, and strong intermolecular interactions.

Reduced Auditory Perception and Brain Response with Quiet TMS Coil.

Background: Electromagnetic forces in transcranial magnetic stimulation (TMS) coils generate a loud clicking sound that produces confounding auditory activation and is potentially hazardous to hearing. To reduce this noise while maintaining stimulation efficiency similar to conventional TMS coils, we previously developed a quiet TMS double containment coil (qTMS-DCC).

Objective: To compare the stimulation strength, perceived loudness, and EEG response between qTMS-DCC and a commercial TMS coil.

Transient chromatin decompaction at the start of male embryonic germline development.

Embryonic germ cells develop rapidly to establish the foundation for future developmental trajectories, and in this process, they make critical lineage choices including the configuration of their unique identity and a decision on sex. Here, we use single-cell genomics patterns for the entire embryonic germline in along with the somatic gonadal precursors after embryonic gonad coalescence to investigate molecular mechanisms involved in the setting up and regulation of the germline program. Profiling of the early germline chromatin landscape revealed sex- and stage-specific features.

Association between allostatic load and depression in patients with sleep disorders: Evidence from the National Health and Nutrition Examination Survey (NHANES).

Objective: Allostatic load (AL) is an indicator of the cumulative wear and tear on the body's physiological systems that can predict onset of a range of health problems. However, the relationship between AL and depression in patients with sleep disorders is unclear. This study explored the association between AL and depression in patients with sleep disorders.

The inappropriate application of imidacloprid destroys the ability of predatory natural enemies to control pests in the food chain: A case study of the feeding behavior of Orius similis on Frankliniella occidentalis.

Insecticides are an indispensable and important tool for agricultural production. However, the inappropriate application of insecticides can cause damage to the food chain and ecosystem. Orius similis is an important predatory and natural enemy of Frankliniella occidentalis.

Dendritic Cell-Derived Exosomes in Cancer Immunotherapy.

Exosomes are nanoscale vesicles released by diverse types of cells for complex intercellular communication. Numerous studies have shown that exosomes can regulate the body's immune response to tumor cells and interfere with the tumor microenvironment (TME). In clinical trials on dendritic cell (DC)-based antitumor vaccines, no satisfactory results have been achieved.

Drought stress in rice: morpho-physiological and molecular responses and marker-assisted breeding.

Rice ( L.) is an essential constituent of the global food chain. Drought stress significantly diminished its productivity and threatened global food security.

Direct detection of virus-like particles using color images of plasmonic nanostructures.

We propose a measurement method for sensitive and label-free detections of virus-like particles (VLPs) using color images of nanoplasmonic sensing chips. The nanoplasmonic chip consists of 5×5 gold nanoslit arrays and the gold surface is modified with specific antibodies for spike protein. The resonant wavelength of the 430-nm-period gold nanoslit arrays underwater environment is about 570 nm which falls between the green and red bands of the color CCD.

Effects of electron transport layer thickness on light extraction in corrugated OLEDs.

This study reported the effects of electron transport layer (ETL) thickness on light extraction in corrugated organic light-emitting diodes (OLEDs) and each layer in OLEDs exhibited a periodical corrugated structure, which was determined by depositing thin films on a glass substrate with a nanoimprinted blazed grating structure. The insight is that light extraction in corrugated OLEDs significantly depends on the ETL thickness. Varying the ETL thickness changed the distribution of carrier recombination and led to exciton formation and optical interference, thereby resulting in different attribution of optical loss modes in OLEDs, which increased or even decreased light extraction and device efficiency.

Classification of Alzheimer's disease in MRI images using knowledge distillation framework: an investigation.

Purpose: Computer-aided MRI analysis is helpful for early detection of Alzheimer's disease(AD). Recently, 3D convolutional neural networks(CNN) are widely used to analyse MRI images. However, 3D CNN requires huge memory cost.

A metric learning-based method using graph neural network for pancreatic cystic neoplasm classification from CTs.

Purpose: Pancreatic cystic neoplasms (PCNs) are relatively rare neoplasms and difficult to be classified preoperatively. Ordinary deep learning methods have great potential to provide support for doctors in PCNs classification but require a quantity of labeled samples and exact segmentation of neoplasm. The proposed metric learning-based method using graph neural network (GNN) aims to overcome the limitations brought by small and imbalanced dataset and get fast and accurate PCNs classification result from computed tomography (CT) images.

Multiplexing the Quantitation of MAP Kinase Activities Using Differential Sensing.

Protein kinases are therapeutic targets for many human diseases, but the lack of user-friendly quantitative assays limits the ability to follow the activities of numerous kinases at once (multiplexing). To develop such an assay, we report an array of sulfonamido-oxine (SOX)-labeled peptides showing cross-reactivity to different mitogen-activated protein kinases (MAPKs) for use in a differential sensing scheme. We first verified using linear discriminant analysis that the array could differentiate MAPK isoforms.

Seas the day: Co-designing immersive virtual reality exergames with exercise professionals and people living with dementia.

Background: Physical activity (PA) is associated with physical and cognitive benefits among people living with dementia or mild cognitive impairment (PLWD/MCI) and is a meaningful activity that can improve their confidence in everyday life. Exercising in virtual reality environments (VR Exergame) is becoming an increasingly feasible and enjoyable way to promote PA and well-being in PLWD/MCI. Although co-design can significantly improve the design of technology, it is rarely done with PLWD/MCI.

Combined Antioxidant-Antibiotic Treatment for Effectively Healing Infected Diabetic Wounds Based on Polymer Vesicles.

Infected diabetic wounds are difficult to heal due to high reactive oxygen species (ROS) concentrations and recurrent infections. Such wounds can easily deteriorate into a diabetic ulcer, a chronic diabetic complication with a very high mortality rate. Herein, we propose a combined antioxidant-antibiotic therapy based on poly(ε-caprolactone)--poly(glutamic acid) polymer vesicle to treat infected diabetic wounds.

Trajectory mapping of the early germline reveals controls of zygotic activation and sex differentiation.

Germ cells in are specified maternally shortly after fertilization and are transcriptionally quiescent until their zygotic genome is activated to sustain further development. To understand the molecular basis of this process, we analyzed the progressing transcriptomes of early male and female germ cells at the single-cell level between germline specification and coalescence with somatic gonadal cells. Our data comprehensively cover zygotic activation in the germline genome, and analyses on genes that exhibit germline-restricted expression reveal that polymerase pausing and differential RNA stability are important mechanisms that establish gene expression differences between the germline and soma.

Acetylcholinesterase electrochemical biosensors with graphene-transition metal carbides nanocomposites modified for detection of organophosphate pesticides.

An acetylcholinesterase biosensor modified with graphene and transition metal carbides was prepared to detect organophosphorus pesticides. Cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy were used to characterize the electrochemical catalysis of the biosensor: acetylcholinesterase/chitosan-transition metal carbides/graphene/glassy carbon electrode. With the joint modification of graphene and transition metal carbides, the biosensor has a good performance in detecting dichlorvos with a linear relationship from 11.

Lysergic acid diethylamide causes mouse retinal damage by up-regulating p-JAK1/p-STAT1.

Lysergic acid diethylamide (LSD) is a powerful hallucinogen with high potential for abuse. There is far less known about its effects on the retina, especially the underlying mechanisms. This study was to investigate the acute toxicity of LSD on the retina of C57 mice and its mechanisms of action.

Measuring the Microphase Separation Scale of Polyurethanes with a Vibration-Induced Emission-Based Ratiometric "Fluorescent Ruler".

Polyurethanes (PUs) are a very attractive type of segmented polymer with unique mechanical properties derived from thermodynamic incompatibility between flexible soft segments and hard segments. The performance of PUs is closely related to their microphase separation structures, in which the hard domains serve as physical cross-linking points in the soft matrix. Studying the microphase separation of PUs in a facile manner is thus of great significance but challenging due to the complexity of the internal structures of PUs.

Polymer LEDs with improved efficacy via periodic nanostructure-based aluminum.

Periodic aluminum-capped nanoslit arrays were produced on a polycarbonate plastic substrate by rapid hot embossing nanoimprint lithography and thermal evaporation, and they were used as a transparent window for blue-emitting polymer light-emitting diodes (PLEDs). The external quantum efficiency of blue-emitting PLEDs was enhanced by the surface plasmon polaritons of the periodic aluminum-capped nanoslit arrays. A maximum current efficiency of 4.