Clinical application of prone position to suppress respiratory movement artifacts in supine position during magnetic resonance cholangiopancreatography/MRI.

Purpose: To compare the image quality of magnetic resonance cholangiopancreatography (MRCP) in the supine position and prone position under the conditions of the same equipment, the same sequence (3D Navigator Triggered Sampling Perfection with Application-Optimized Contrast Using Different Flip-angle Evolutions, 3D-NT-SPACE) and the same patient, and to explore the clinical application value of prone position in MRCP examination to suppress respiratory motion artifacts.

Methods: 53 participants who underwent MRCP in our hospital from April 2020 to August 2022 were prospectively collected. The 3D-NT-SPACE sequence was used in these patients.

Dissemination of antibiotic resistance genes from aboveground sources to groundwater in livestock farms.

Antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are prevalent in various environments on livestock farms, including livestock waste, soil, and groundwater. Contamination of groundwater by ARB and ARGs in livestock farms is a growing concern as it may have potentially huge risks to human health. However, the source of groundwater-borne ARB and ARGs in animal farms remains largely unknown.

Reactive oxygen species mediated extracellular polymeric substances production assisting the recovery of Thalassiosira pseudonana from polystyrene micro and nanoplastics exposure.

As emerging pollutants in the aquatic environments, micro- and nano-plastics (MNPs) aroused widespread environmental concerns for their potential threats to the ecological health. Previous research has proved that microalgae growth could recover from the MNPs toxicities, in which the extracellular polymeric substances (EPS) might play the key role. In order to comprehensively investigate the recovery process of microalgae from MNPs stress and the effecting mechanisms of EPS therein, this study conducted a series of experiments by employing two sizes (0.

A High-Energy Tellurium Redox-Amphoteric Conversion Cathode Chemistry for Aqueous Zinc Batteries.

Rechargeable aqueous zinc batteries are potential candidates for sustainable energy storage systems at a grid scale, owing to their high safety and low cost. However, the existing cathode chemistries exhibit restricted energy density, which hinders their extensive applications. Here, a tellurium redox-amphoteric conversion cathode chemistry is presented for aqueous zinc batteries, which delivers a specific capacity of 1223.

ROS meditated paralytic shellfish toxins production changes of Alexandrium tamarense caused by microplastic particles.

A variety of studies have investigated the toxic effects of microplastics (MPs) on microalgae, but few of them considered their influence on dinoflagellate toxins production, which could cause significant ecological safety concerns in coastal areas. This research investigated the impacts of 5 μg L and 5 mg L polystyrene (PS) MPs on the changes of paralytic shellfish toxins (PSTs) production and their relationship with cellular oxidative stress of Alexandrium tamarense, a common harmful algal blooms causative dinoflagellate. The results showed elevation of reactive oxygen species (ROS) levels, activation of antioxidant system and overproduction of PSTs were positively correlated under PS MPs exposure (especially under 5 mg L PS MPs), and the PSTs changes were eliminated by the ROS inhibitor.

UV-B radiation alleviated detrimental effects of polymethyl methacrylate microplastics on marine diatom Thalassiosira pseudonana.

Microplastics (MPs) in marine environments simultaneously affect microalgae with UV-B radiation, while their joint effecting mechanisms remain largely unknown. To fill this research gap, the joint effects of polymethyl methacrylate (PMMA) MPs and UV-B radiation (natural environments intensity) on the model marine diatom Thalassiosira pseudonana were investigated. Antagonism was found between the two factors with regards to population growth.

Realizing Highly-Ordered Laser-Reduced Graphene for High-Performance Flexible Microsupercapacitor.

Laser reduction of graphene oxide (GO) with direct-write technology is promising to develop miniaturized energy storage devices because of highly flexible, mask-free, and chemical-free merits. However, laser reduction of GO is often accompanied with deflagration (spectacular and violent deoxygenating reaction), leading reduced graphene oxide (rGO) films into brittle and irregular internal structure which is harmful to the applications. Here, a pre-reduction strategy is demonstrated to avoid this deflagration and realize a uniform laser-reduced GO (LrGO) matrix for the application of flexible micro-supercapacitors (MSCs).

The inhibition and recovery mechanisms of the diatom Phaeodactylum tricornutum in response to high light stress - A study combining physiological and transcriptional analysis.

By combining physiological/biochemical and transcriptional analysis, the inhibition and recovery mechanisms of Phaeodactylum tricornutum in response to extreme high light stress (1300 μmol photons · m  · s ) were elucidated. The population growth was inhibited in the first 24 h and started to recover from 48 h. At 24 h, photoinhibition was exhibited as the changes of PSII photosynthetic parameters and decrease in cellular pigments, corresponding to the downregulation of genes encoding light-harvesting complex and pigments synthesis.

The adsorption and absorption kinetics of BDE-47 by Chlorella sp. and the role of extracellular polymer substances influenced by environmental factors.

Microalgae act as the entrance of polybrominated diphenyl ethers (PBDEs) from abiotic to biotic environments, which controlled the environmental fate of PBDEs in aquatic environments. Combing with typical coastal environmental characteristics including extracellular polymer substances (EPS) enrichment, light limitation and nitrogen starvation, the changes of adsorption and absorption kinetics of BDE-47 by Chlorella sp. and the role of EPS therein were investigated.

Different effecting mechanisms of two sized polystyrene microplastics on microalgal oxidative stress and photosynthetic responses.

Increasing marine microplastics (MPs) pollution potentially threatens the stability of phytoplankton community structures in marine environments. MPs toxicities to microalgae are largely determined by particle size, while the size-dependent mechanisms are still not fully understood. In this study, two sizes (0.

Paper Device Combining CRISPR/Cas12a and Reverse-Transcription Loop-Mediated Isothermal Amplification for SARS-CoV-2 Detection in Wastewater.

Wastewater-based surveillance of the COVID-19 pandemic holds great promise; however, a point-of-use detection method for SARS-CoV-2 in wastewater is lacking. Here, a portable paper device based on CRISPR/Cas12a and reverse-transcription loop-mediated isothermal amplification (RT-LAMP) with excellent sensitivity and specificity was developed for SARS-CoV-2 detection in wastewater. Three primer sets of RT-LAMP and guide RNAs (gRNAs) that could lead Cas12a to recognize target genes via base pairing were used to perform the high-fidelity RT-LAMP to detect the N, E, and S genes of SARS-CoV-2.

Toxicity of 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47) on the green microalgae Chlorella sp. and the role of cellular oxidative stress.

Polybrominated diphenyl ethers (PBDEs) are toxic to marine organisms including the major primary producer phytoplankton, while the toxic mechanisms haven't yet been fully clarified. Therefore, we comprehensively studied the toxic mechanisms of BDE-47 on the marine chlorophyte Chlorella sp., with a focus on the role of cellular oxidative stress.

The effects of two sized polystyrene nanoplastics on the growth, physiological functions, and toxin production of Alexandrium tamarense.

Micro- and nano-plastics (MNPs) are increasingly prevalent pollutants in marine ecosystems and result in various deleterious effects on marine organisms. There have been studies evaluated the toxic effects of MNPs on marine microalgae, but few of them focused on the effects of MNPs on dinoflagellate species and their toxins production, which could have significant implications on human health and ecological safety in coastal areas. In this study, the common harmful algal blooms-causing dinoflagellate Alexandrium tamarense was exposed to 0.

Improved lithium-ion battery performance by introducing oxygen-containing functional groups by plasma treatment.

Metal sulfides are often used as cathode materials for lithium-ion batteries (LIBs) owing to their high theoretical specific capacity; however, excessively fast capacity decay during charging/discharging and rapid shedding during cycling limits their practical application in batteries. In this study, we proposed a strategy using plasma treatment combined with the solvothermal method to prepare cobalt sulfide (CoS)-carbon nanofibers (CNFs) composite. The plasma treatment could introduce oxygen-containing polar groups and defects, which could improve the hydrophilicity of the CNFs for the growth of the CoS, thereby increasing the specific capacity of the composite electrode.

The molecular response mechanisms of a diatom Thalassiosira pseudonana to the toxicity of BDE-47 based on whole transcriptome analysis.

Polybrominated diphenyl ethers (PBDEs) are ubiquitously distributed persistent organic pollutants (POPs) in marine environments. Phytoplankton are the entrance of PBDEs entering to biotic environments from abiotic environments, while the responding mechanisms of phytoplankton to PBDEs have not been full established. Therefore, we chose the model diatom Thalassiosira pseudonana in this study, by integrating whole transcriptome analysis with physiological-biochemical data, to reveal the molecular responding mechanisms of T.

The toxicity, bioaccumulation and debromination of BDE-47 and BDE-209 in Chlorella sp. under multiple exposure modes.

Polybrominated diphenyl ethers (PBDEs) are a series of important persistent organic pollutants (POPs) in marine environments. Microalgae are the start of PBDEs bioaccumulated and bioconcentrated along the marine food web. In order to investigate the variations of PBDEs bioaccumulation by microalgae and its influencing factors, we set up a series of experiments with Chlorella sp.

ROS-mediated programmed cell death (PCD) of Thalassiosira pseudonana under the stress of BDE-47.

Polybrominated diphenyl ethers (PBDEs) are a series of highly persistent organic pollutants (POPs) ubiquitously distributed in marine environments. As key primary producers, microalgae are the start of PBDEs bioaccumulations and vulnerable to their toxicities. In order to deeply investigate the toxic mechanism of PBDEs on microalgal cells, the occurrence of programmed cell death (PCD) in a model diatom Thalassiosira pseudonana and its possible mediating mechanism were studied.

Incidence patterns of traumatic upper limb fractures in children and adolescents: Data from medical university-affiliated hospitals in Chongqing, China.

China's child population ranked second in the world. However, data on the overall patterns and epidemiologic trends of TULFs among children and adolescents in Chongqing, China are scarce. With development of urbanization, motorization, building industry, the incidence patterns of traumatic upper limb fractures in children and adolescents might be about to change.

Layered coating of ultraflexible graphene-based electrodes for high-performance in-plane quasi-solid-state micro-supercapacitors.

To meet the demand of rapid development of portable and wearable electronic devices, in-plane quasi-solid-state micro-supercapacitors (QSS MSCs) have great potential as miniaturized energy storage devices. However, their ultralow areal capacitance and poor flexibility limit their practical applications. Here, we demonstrate a new strategy for the fabrication of ultraflexible MnO2@reduced graphene oxide (rGO) films (MGFs) for high-performance planar QSS MSCs through a facile layer-by-layer coating and a laser engraving method.

The toxic mechanisms of BDE-47 to the marine diatom Thalassiosira pseudonana-a study based on multiple physiological processes.

Polybrominated diphenyl ethers (PBDEs), a series of highly persistent organic pollutants (POPs), are ubiquitous in marine ecosystems. As key primary producers, microalgae are of great importance on evaluating the environmental outcome of PBDEs pollution. In this study, the toxic mechanisms of BDE-47 on the marine diatom Thalassiosira pseudonana were evaluated by measuring multiple physiological processes.

Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system.

Background: Infliximab (Remicade), a chimeric monoclonal antibody against human TNFα, will inevitably face competition from biosimilar products, because of its effectiveness in autoimmune diseases and rapidly increasing market demand. According to guidelines for biosimilar development, the "biosimilar-expression system" may differ from that of the innovator, but more appropriate studies should be carried out to demonstrate the comparability between biosimilar and innovator. CMAB008 is an infliximab biosimilar candidate developed by the State Key Laboratory of Antibody Medicine and Targeted Therapy of China.

[Integration of clinical pathway construction and hospital information system in intensive care unit is the core of digitalized hospital: experience of clinical pathway construction in Liuzhou Worker's Hospital from 2016 to 2018].

Objective: To explore the effective strategies of clinical pathway construction in intensive care unit (ICU).

Methods: From January 2016 to July 2018, 1 488 patients were discharged from ICU of Liuzhou Worker's Hospital of Guangxi Zhuang Autonomous Region. The pilot project of "postoperative monitoring of heart disease" with simpler route and less variation was selected first, and then the pilot project was promoted to "post-operative monitoring" after its success.

Aerobic exercise-stimulated Klotho upregulation extends life span by attenuating the excess production of reactive oxygen species in the brain and kidney.

Aerobic exercise induces many adaptive changes in the whole body and improves metabolic characteristics. Klotho, an anti-aging gene, is mainly expressed in the brain and kidney. The roles of Klotho in the brain and kidney during aerobic exercise remain largely unknown.

The anti-ErbB2 antibody H2-18 and the pan-PI3K inhibitor GDC-0941 effectively inhibit trastuzumab-resistant ErbB2-overexpressing breast cancer.

Trastuzumab, an anti-ErbB2 humanized antibody, brings benefit to patients with ErbB2-amplified metastatic breast cancers. However, the resistance to trastuzumab is common. Our previously reported H2-18, an anti-ErbB2 antibody, potently induced programmed cell death in trastuzumab-resistant breast cancer cells.