High-voltage pulsed electric field (HV-PEF) ablation is a potential new treatment for chronic obstructive pulmonary disease (COPD), but research is still in early stages and the mechanisms are unclear.
Rats are chosen as the primary model for these studies due to their suitability for COPD modeling and available research tools.
The study focused on designing specialized electrodes for HV-PEF in rats, examining various specifications to ensure safety and effectiveness, leading to simulations that support future research on this treatment's mechanisms.