Publications by authors named "Yirga Legesse Nirayo"

Introduction: Ethiopia has one of the highest HIV burdens in sub-Saharan Africa. Despite the fact that second-line antiretroviral therapy (ART) has been available for more than ten years, studies on its effectiveness are scarce.

Objective: To assess treatment outcomes and predictors of unfavorable outcomes in HIV patients receiving second-line ART at Ayder Comprehensive Specialized Hospital and Mekelle Hospital.

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Article Synopsis
  • - The study investigates how sociodemographic factors relate to injury-related health outcomes worldwide, specifically analyzing disability-adjusted life years (DALYs) from injuries across 195 countries from 1990 to 2017.
  • - Findings show that while most injury causes display a trend of decreasing DALY rates with higher Socio-demographic Index (SDI), certain injuries like road injuries, interpersonal violence, and self-harm deviate from this trend, indicating complex underlying factors.
  • - The research highlights the importance of understanding these injury patterns to improve health strategies and intervention efforts at both national and global levels, especially since not all injuries follow the same developmental trajectory.
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Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2-to end preventable child deaths by 2030-we need consistently estimated data at the subnational level regarding child mortality rates and trends.

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Article Synopsis
  • Cancer and other noncommunicable diseases (NCDs) pose a significant threat to global development, with slow progress in addressing these issues highlighted by the recent UN meeting; key barriers include a lack of situational analyses and prioritization for effective action against NCDs.* -
  • The study aims to provide comprehensive data on cancer burden across 29 cancer types in 195 countries from 1990 to 2017, utilizing the Global Burden of Disease (GBD) methods to analyze cancer incidence, mortality, and disability metrics.* -
  • In 2017, there were 24.5 million new cancer cases globally, with significant variations based on socio-demographic factors; the majority of cancer-related disabilities stemmed
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Importance: Understanding causes and correlates of health loss among children and adolescents can identify areas of success, stagnation, and emerging threats and thereby facilitate effective improvement strategies.

Objective: To estimate mortality and morbidity in children and adolescents from 1990 to 2017 by age and sex in 195 countries and territories.

Design, Setting, And Participants: This study examined levels, trends, and spatiotemporal patterns of cause-specific mortality and nonfatal health outcomes using standardized approaches to data processing and statistical analysis.

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Objective: The main objective of this study was to assess time to death and associated risk factors among tuberculosis (TB) patients.

Results: A total of 769 TB patients were studied and of those, 87 (11.3%) patients died.

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