M6A modification-mediated LIMA1 promotes the progression of hepatocellular carcinoma through the wnt-βcatenin/Hippo pathway.

Background: Hepatocellular carcinoma (HCC), considered as one of the most common and lethal cancers worldwide, has drawn significant attention from researchers.Extensively studied diverse cancers, the function of LIMA1 in tumorigenesis and cancer progression remains ambiguous..

PPM1G and its diagnostic, prognostic and therapeutic potential in HCC (Review).

Global statistics indicate that hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer‑related death. Protein phosphatase Mg/Mn dependent 1G (PPM1G, also termed PP2Cγ) is one of the 17 members of the PPM family. The enzymatic activity of PPM1G is highly reliant on Mg or Mn and serves as a dephosphorylation regulator for numerous key proteins.

CircWHSC1 (CircNSD2): A Novel Circular RNA in Multiple Cancers.

Circular RNAs (circRNAs) are a type of non-coding RNA (ncRNA) that possesses a unique single-stranded circular structure. They are primarily formed through alternative splicing of pre-mRNA (messenger RNA). The primary biological function of circRNAs is to regulate gene expression at both the transcriptional and post-transcriptional levels.

Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers.

Actin is the most abundant and highly conserved cytoskeletal protein present in all eukaryotic cells. Remodeling of the actin cytoskeleton is controlled by a variety of actin-binding proteins that are extensively involved in biological processes such as cell motility and maintenance of cell shape. LIM domain and actin-binding protein 1 (LIMA1), as an important actin cytoskeletal regulator, was initially thought to be a tumor suppressor frequently downregulated in epithelial tumors.

Optimal control and cost-effectiveness analysis for a COVID-19 model with individual protection awareness.

This paper is focused on the design of optimal control strategies for COVID-19 and the model containing susceptible individuals with awareness of protection and susceptible individuals without awareness of protection is established. The goal of this paper is to minimize the number of infected people and susceptible individuals without protection awareness, and to increase the willingness of susceptible individuals to take protection measures. We conduct a qualitative analysis of this mathematical model.

Three State Estimation Fusion Methods Based on the Characteristic Function Filtering.

There are three state estimation fusion methods for a class of strong nonlinear measurement systems, based on the characteristic function filter, namely the centralized filter, parallel filter, and sequential filter. Under ideal communication conditions, the centralized filter can obtain the best state estimation accuracy, and the parallel filter can simplify centralized calculation complexity and improve feasibility; in addition, the performance of the sequential filter is very close to that of the centralized filter and far better than that of the parallel filter. However, the sequential filter can tolerate non-ideal conditions, such as delay and packet loss, and the first two filters cannot operate normally online for delay and will be invalid for packet loss.

Working Memory Predicts Hypothalamus-Pituitary-Adrenal Axis Response to Psychosocial Stress in Males.

The hypothalamic-pituitary-adrenocortical (HPA) function is crucial for adaptation to stress and recovery of homeostasis. Physiological alteration in the HPA axis has been shown to play a pivotal role in the generation of stress-related disorders. A growing number of studies have begun to identify which variables are possible to predict individual HPA response and associated stress vulnerability.

The cortisol awakening response predicts response inhibition in the afternoon of the same day.

The cortisol awakening response (CAR) is the rapid increase of cortisol levels 30-45 min after awakening in the morning. Numerous studies have indicated the relationship between the CAR and cognition. However, little is known about daily variation in the CAR and cognitive function in healthy adults.

Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility.

The medial prefrontal cortex (mPFC) and its output area, the nucleus accumbens (NAc), are implicated in mediating attentional set-shifting. Patients with posttraumatic stress disorder (PTSD) exhibit difficulties in the disengagement of attention from traumatic cues, which is associated with impairments in set-shifting ability. However, unknown is whether alterations in corticostriatal function underlie deficits in this behavioral flexibility in individuals with PTSD.

The effects of long-term stress on neural dynamics of working memory processing: An investigation using ERP.

This study examined the neural dynamics of working memory (WM) processing under long-term stress. Forty participants who had been exposed to a long period of major exam preparation (six months) and twenty-one control participants performed a numerical n-back task (n = 1, 2) while electroencephalograms were recorded. Psychological and endocrinal measurements confirmed significantly higher levels of long-term stress for participants in the exam group.

High cortisol awakening response is associated with impaired error monitoring and decreased post-error adjustment.

The cortisol awakening response (CAR), a rapid increase in cortisol levels following morning awakening, is an important aspect of hypothalamic-pituitary-adrenocortical axis activity. Alterations in the CAR have been linked to a variety of mental disorders and cognitive function. However, little is known regarding the relationship between the CAR and error processing, a phenomenon that is vital for cognitive control and behavioral adaptation.

Identifying risky drivers with simulated driving.

Objective: The present study aimed to examine whether high-risk drivers differ from low-risk drivers in driving behavior in a simulated environment.

Method: The 2 risk groups including 36 drivers (18 males and 18 females) performed driving tasks in a simulated environment. The simulated driving behaviors are compared between the 2 risk groups.

The relationship between response inhibition and posttraumatic stress symptom clusters in adolescent earthquake survivors: an event-related potential study.

Posttraumatic stress disorder (PTSD) patients experience impaired response inhibition. Little is known about the relationship between response inhibition abnormalities and distinct PTSD symptom clusters. This study investigated the relationship between response inhibition processing and a five-factor model of posttraumatic stress symptomatology in adolescents.

Anticipatory processes under academic stress: an ERP study.

It is well known that preparing for and taking high-stakes exams has a significant influence on the emotional and physiological wellbeing of exam-takers, but few studies have investigated the resulting cognitive changes. The current study examined the effect of examination-induced academic stress on anticipation in information processing. Anticipation was indexed using the contingent negative variation (CNV).

Long-term academic stress increases the late component of error processing: an ERP study.

Exposure to long-term stress has a variety of consequences on the brain and cognition. Few studies have examined the influence of long-term stress on event related potential (ERP) indices of error processing. The current study investigated how long-term academic stress modulates the error related negativity (Ne or ERN) and the error positivity (Pe) components of error processing.

Chronic stress exposure decreases the cortisol awakening response in healthy young men.

Academic examination is a major stressor for students in China. Investigation of stress-sensitive endocrine responses to major examination stress serves as a good model of naturalistic chronic psychological stress in an otherwise healthy population. The cortisol awakening response (CAR) is an endocrine marker of the hypothalamic-pituitary-adrenocortical (HPA) axis in response to stress.