Endogenous Magnetic Lipid Droplet-Mediated Cascade-Targeted Sonodynamic Therapy as an Approach to Reversing Breast Cancer Multidrug Resistance.

Multidrug resistance (MDR) has emerged as a major barrier to effective breast cancer treatment, contributing to high rates of chemotherapy failure and disease recurrence. There is thus a pressing need to overcome MDR and to facilitate the efficient and precise treatment of breast cancer in a targeted manner. In this study, endogenous functional lipid droplets (IR780@LDs-FeO/OA) were developed and used to effectively overcome the limited diffusion distance of reactive oxygen species owing to their amenability to cascade-targeted delivery, thereby facilitating precise and effective sonodynamic therapy (SDT) for MDR breast cancer.

Application of microvascular ultrasound-assisted thyroid imaging report and data system in thyroid nodule risk stratification.

Objectives: To establish superb microvascular imaging (SMI) based thyroid imaging reporting and data system (SMI TI-RADS) for risk stratification of malignancy in thyroid nodules.

Methods: In total, 471 patients, comprising 643 thyroid nodules, who received conventional ultrasound (US), SMI, and a final diagnosis were extensively analyzed. A qualitative assessment of US features of the nodules was performed followed by univariable and multivariable logistic regression analyses, leading to the construction of the SMI TI-RADS, which was further verified using internal and external validation cohorts.

Automated Diagnosis and Phenotyping of Tuberculosis Using Serum Metabolic Fingerprints.

Tuberculosis (TB) stands as the second most fatal infectious disease after COVID-19, the effective treatment of which depends on accurate diagnosis and phenotyping. Metabolomics provides valuable insights into the identification of differential metabolites for disease diagnosis and phenotyping. However, TB diagnosis and phenotyping remain great challenges due to the lack of a satisfactory metabolic approach.

Self-Supporting Triphase Photocatalytic CO Reduction to CHOH on Controllable Core-Shell Structure with Tunable Interfacial Wettability.

Enhancing the CO mass transfer and proton supply in the photocatalytic reduction of CO with HO into CHOH (PRC-M), while avoiding the hydrogen evolution reaction (HER), remains a challenge. Herein, we propose an approach to control the surface coverage of CO and HO by modifying interfacial wettability, which is achieved by modulating the core-shell structure to expose either hydrophobic melamine-resorcinol-formaldehyde (MRF) or hydrophilic NiAl-layered double hydroxides (NAL). Characterizations reveal that an insufficient proton supply leads to the production of competing CO, while excessive coverage of HO results in undesired HER.

Highly Reversibly Stretchable and Elastically Wearable Textile Supercapacitor.

Rapid and full recovery is the major challenge for the commercialization and further growth of textile-based wearable supercapacitors. Herein, reversibly stretchable and rapidly reboundable textile supercapacitors (TSCs) are developed via the utilization of NiCuSe/Cu-Ni alloy-plated cotton cloth (CNAPCC) textile as the cathode and FeCuSe/CNAPCC textile as the anode. Both NiCuSe/CNAPCC and FeCuSe/CNAPCC are obtained by a simple in situ oxidation reaction, followed by an ion exchange strategy.

Catalytically Active Metal-Organic Frameworks Elicit Robust Immune Response to Combination Chemodynamic and Checkpoint Blockade Immunotherapy.

Chemodynamic therapy (CDT) strategies rely on the generation of reactive oxygen species (ROS) to kill tumor cells, with hydroxyl radicals (OH) serving as the key mediators of cytotoxicity in this setting. However, the efficacy of CDT approaches is often hampered by the properties of the tumor microenvironment (TME) and associated limitations to the Fenton reaction that constrains ROS generation. As such, there is a pressing need for the design of new nanoplatforms capable of improving CDT outcomes.

Synergistic effect of F and triggered oxygen vacancies over F-TiO on enhancing NO ozonation.

Oxidation-absorption technology is a key step for NO removal from low-temperature gas. Under the condition of low O concentration (O/NO molar ratio = 0.6), F-TiO (F-TiO), which is cheap and environmentally friendly, has been prepared as ozonation catalysts for NO oxidation.

TiSe-mediated sonodynamic and checkpoint blockade combined immunotherapy in hypoxic pancreatic cancer.

Background: Pancreatic cancer remains among the most prevalent and aggressive forms of cancer. While immunotherapeutic treatment strategies have shown some promise in affected patients, the benefits of these interventions have been limited by insufficient tumor infiltration by activated T cells.

Results: Here, Titanium diselenide (TiSe) nanosheets were synthesized with good stability.

Collagenase-Loaded H-TiO Nanoparticles Enhance Ultrasound Imaging-Guided Sonodynamic Therapy in a Pancreatic Carcinoma Xenograft Model via Digesting Stromal Barriers.

Sonodynamic therapy (SDT), a noninvasive therapy that relies on sonosensitizers and generates reactive oxygen species (ROS), has attracted considerable attention in the treatment of pancreatic cancer. However, being surrounded by dense stromal barriers, pancreatic cancer exhibits high interstitial fluid pressure (IFP) and hypoxia in the tumor microenvironment (TME), resulting in poor SDT efficacy. Collagenase-loaded hollow TiO (Col-H-TiO) nanoparticles (NPs) capable of degrading stromal barriers and producing sufficient ROS production were synthesized in this study.

Ultrasound improved immune adjuvant delivery to induce DC maturation and T cell activation.

Tumor immunotherapy has emerged as a promising approach to tumor treatment. Currently, immune adjuvant-based therapeutic modalities are rarely curative in solid tumors owing to challenges including the low permeability and extremely poor water solubility of these adjuvants, limiting their ability to effectively promote dendritic cell (DC) maturation. Herein, we employed ultrasound-mediated cavitation (UMC) to promote the delivery of Toll-like receptor agonist (R837)-loaded pH-responsive liposomes (PEOz-Lip@R837) to tumors.

Snare-assisted flexible endoscope in trans-gastric endoscopic gallbladder-preserving surgery: A pilot animal study.

Background: Natural orifice transluminal endoscopic surgery (NOTES) gallbladder-preserving surgery by flexible endoscopy is an emerging technology. However, the gallbladder fails to obtain traction and positioning functions during the operation.

Aim: To evaluate the feasibility and safety of a new surgical method, "snare-assisted pure NOTES gallbladder-preserving surgery".

Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study.

Medical diagnostic imaging is essential for the differential diagnosis of cervical lymphadenopathy. Here we develop an ultrasound radiomics method for accurately differentiating cervical lymph node tuberculosis (LNTB), cervical lymphoma, reactive lymph node hyperplasia, and metastatic lymph nodes especially in the multi-operator, cross-machine, multicenter context. The inter-observer and intra-observer consistency of radiomics parameters from the region of interest were 0.

Enhancement of antitumor immunotherapy using mitochondria-targeted cancer cell membrane-biomimetic MOF-mediated sonodynamic therapy and checkpoint blockade immunotherapy.

Immunotherapeutic interventions represent a promising approach to treating cancer, with strategies such as immune checkpoint blockade (ICB), immunogenic sonodynamic therapy (SDT), and immune adjuvant T cell delivery having exhibited clinical promise. In this report, we describe the use of cancer cell membrane-coated triphenylphosphonium (TPP) decorated nano-metal-organic framework (nMOF) constructs [Zr-TCPP(TPP)/R837@M] that were used to generate homologous, mitochondria-targeted platforms with a high rate of sonosensitizer loading. This construct was utilized to simultaneously promote tumor antigen presentation via enhancing SDT while synergistically promoting dendritic cell (DC) maturation through the delivery of the Toll-like receptor agonist R837.

Ag and MOFs-derived hollow CoO decorated in the 3D g-CN for creating dual transferring channels of electrons and holes to boost CO photoreduction performance.

The rapid recombination of photoinduced charge carriers and low selectivity are still challenges for the CO photoreduction. Herein, we proposed that ZIF-67-derived CoO hollow polyhedrons (CoHP) were embedded into NaCl-template-assisted synthesized 3D graphitic carbon nitride (NCN), subsequently, loading Ag by photo-deposition as efficient composites (CoHP@NCN@Ag) for CO photoreduction. This integration simultaneously constructs two heterojunctions: p-n junction between CoO and g-CN and metal-semiconductor junction between Ag and g-CN, in which CoO and Ag serve as hole (h) trapping sites and electron (e) sinks, respectively, achieving spatial separation of charge carriers.

Metal-Organic Framework (MOF)-Based Ultrasound-Responsive Dual-Sonosensitizer Nanoplatform for Hypoxic Cancer Therapy.

Sonodynamic therapy (SDT), which uses reactive oxygen species to target tumors, has shown promise in the management of unresectable cancers. However, the hypoxic tumor environment limits SDT efficiency, making complete tumor destruction challenging. Here, a dual-sonosensitizer nanoplatform is developed by loading an alkyl radical generator (2,2-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride, AIPH) onto a zirconium metal-organic framework (Zr-MOF).

Effect of pre-oxidation process on VO/AC catalyst for the selective catalytic reduction of NO with NH.

Activated coke-based catalysts have attracted extensive attention in denitration by selective catalytic reduction by NH (NH-SCR), due to their excellent catalytic performance at low temperature. In the paper, the VO/AC catalyst was prepared by the impregnation method to investigate the effect of pre-oxidation process on its NH-SCR activity. Activity test results show that the VO/AC catalyst with 4-h pre-oxidation exhibits the best NO removal efficiency, which reaches the NO conversion is over 75% in the range of 200-240 °C and exhibits an excellent resistance to SO and HO.

Hypoxia-Adapted Sono-chemodynamic Treatment of Orthotopic Pancreatic Carcinoma Using Copper Metal-Organic Frameworks Loaded with an Ultrasound-Induced Free Radical Initiator.

The efficacy of sonodynamic therapy (SDT) is largely dependent upon oxygen availability to generate deleterious reactive oxygen species, and as such, hypoxic microenvironments greatly constrain the efficacy of SDT. Development of free radical generators that are not dependent on oxygen and related combination treatment strategies thus have the potential to enhance the antitumor potential of SDT. Combined treatment strategies are expected to improve the efficacy of sonodynamic antitumor therapy.

Tablet-like TiO/C nanocomposites for repeated type I sonodynamic therapy of pancreatic cancer.

Sonodynamic therapy (SDT) represents a viable approach to overcoming the limited ability of photodynamic therapy to penetrate biological barriers. However, pancreatic tumors contain a hypoxic microenvironment that limits the efficacy of oxygen-dependent type II SDT, complicating efforts to develop reliable, stable, and hypoxia-tolerant sonosensitizer. Herein, a tablet-like TiO/C nanocomposite with a metal-organic-framework (MOF)-derived carbon structure was designed and found to be hypoxia-tolerant and stable in response to repeated ultrasound irradiation, enabling the TiO/C-mediated generation of large quantities of reactive oxygen species (ROS) and thereby achieving efficacious type I SDT.

Double redox process to synthesize CuO-CeO catalysts with strong Cu-Ce interaction for efficient toluene oxidation.

In this study, a novel double redox (DR) method was developed to synthesize highly active CuO-CeO (CuCe-DR) catalyst for catalytic oxidative decomposition of toluene. Compare with CuCe-C catalyst prepared by co-precipitation method, CuCe-DR catalyst exhibits a higher Ce ion and incorporated Cu ion concentration, and has a stronger Cu-Ce interaction. Ce and incorporated Cu ions can induce the formation of oxygen vacancies, and thus increasing the amount of surface chemisorbed oxygen on CuCe-DR catalyst.

Macrophage interactions with collecting duct epithelial cells are capable of driving tubulointerstitial inflammation and fibrosis in immunoglobulin A nephropathy.

Background: Tubulointerstitial fibrosis is a powerful predictor of future progression inimmunoglobulin A (IgA) nephropathy (IgAN). Proximal tubular epithelial cells (PTECs), in concert with infiltrating macrophages, are regarded as the agents provocateurs for driving this fibrotic process. However, evidence is now emerging for a contributory role of the distal nephron.

Partial substitution of magnesium in lanthanum manganite perovskite for nitric oxide oxidation: The effect of substitution sites.

Lanthanum manganite (LaMnO) with magnesium (Mg) substituted the A- and B-sites were reported for the first time in this work. The Mg substituted LaMnO catalysts were prepared by means of citric acid sol-gel method. The impact of partial substitution of Mg and its substitution site on the catalytic performance of LaMnO in nitric oxide (NO) oxidation was investigated.

Mechanism study on TiO inducing O and OH radicals in O/HO system for high-efficiency NO oxidation.

To achieve high NO oxidation efficiency, excessive O must be used, which would lead to the high cost and escape of ozone. Herein, we adopted low cost and environmental-friendly TiO as the catalyst of low concentration O and HO system for high-efficiency NO oxidation. The Ti sites on TiO were the deprotonation sites of HO and HO into Ti-OOH and Ti-OH species, respectively.

Ni and Zn co-substituted Co(CO)OH self-assembled flowers array for asymmetric supercapacitors.

The supercapacitive performance of high-rate capacity and long-term cycling stability is still a big challenge for electroactive materials. Herein, Ni and Zn co-substituted Co carbonate hydroxide (NiZn-CoCH) flowers array is self-assembled on nickel foams (NFs) using l-ascorbic acid as a nanostructure inducer. The NiZn-CoCH flowers, consisting of silk-like nanosheets, are deservedly large electrode-electrolyte contact area and suitable ion-diffusion channel.

The effect of CuO loading on different method prepared CeO catalyst for toluene oxidation.

The support effect on CeO supported CuO catalysts are extensively investigated, but few studies have been reported in volatile organic compounds (VOCs) oxidation. Herein, CuO was impregnated on three conventional method synthesized CeO to study its impact on toluene total oxidation over CeO at low temperature (≤280 °C). Characterization results demonstrated that the shape and specific surface area of CeO affected the degree of CuO dispersion, which determine the interaction between CuO and CeO.

The utilization of dye wastewater in enhancing catalytic activity of CeO-TiO mixed oxide catalyst for NO reduction and dichloromethane oxidation.

Waste is a misplaced resource. Herein, anionic (orange II sodium salt and Ponceau 2R) and cationic (Rhodamine B and Methylene blue) dye wastewater assisted photo-treatment (referred as DAPT) method was developed to modify sol-gel synthesized CeO-TiO (CeTi) mixed oxide catalyst. Catalytic activity test results showed that both anionic and cationic dye wastewater could be used as "fuel" of photo-treatment to enhance the activity of CeTi catalyst in NO reduction and dichloromethane oxidation.