Publications by authors named "Yiqing Yang"

Atrial fibrillation (AF) signifies the most prevalent supraventricular arrhythmia in humans and may lead to cerebral stroke, cardiac failure, and even premature demise. Aggregating strong evidence points to genetic components as a cornerstone in the etiopathogenesis of familial AF. However, the genetic determinants for AF in most patients remain elusive.

View Article and Find Full Text PDF

Rationale: Cardiac-expressed long noncoding RNAs (lncRNAs) are important for cardiomyocyte (CM) differentiation and function. Several lncRNAs have been identified and characterized for early CM lineage commitment, however those in later CM lineage specification and maturation remain less well studied. Moreover, unique atrial / ventricular lncRNA expression has never been studied in detail.

View Article and Find Full Text PDF

With advancements in computing technology and the rapid progress of data science, machine learning has been widely applied in various fields, showing great potential, especially in digital healthcare. In recent years, conversational diagnostic systems have been used to predict diseases through symptom checking. Early systems predicted the likelihood of a single disease by minimizing the number of questions asked.

View Article and Find Full Text PDF

STAT6 is an attractive therapeutic target for human cancers and other human diseases. Starting from a STAT6 ligand with = 3.5 μM binding affinity, we obtained AK-068 with = 6 nM to STAT6 and at least >85-fold binding selectivity over STAT5.

View Article and Find Full Text PDF
Article Synopsis
  • * In a trial involving 40 patients with Grade 1 hypertension, LL-TS was effective in significantly lowering both systolic and diastolic blood pressure over three months compared to a control group.
  • * The study concluded that LL-TS is a promising approach for managing hypertension in young patients, but further research is necessary to confirm its safety and effectiveness.
View Article and Find Full Text PDF
Article Synopsis
  • The RNA helicase DDX21, crucial for ribosome production, is found to be increased in colorectal cancer (CRC) but its role in tumor growth is not well understood.
  • Research indicates that DDX21 is directly activated by β-catenin, a key player in CRC, and high levels of DDX21 are linked to worse outcomes for patients.
  • Loss of DDX21 affects YAP's function, reducing CRC cell growth and movement, and ribosomal stress appears to enhance DDX21 expression through a specific stress response pathway, suggesting new treatment strategies that target ribosomal stress and YAP inhibition.
View Article and Find Full Text PDF

Rationale And Objectives: This study aimed to develop predictive models based on conventional magnetic resonance imaging (cMRI) and radiomics features for predicting human epidermal growth factor receptor 2 (HER2) status of breast cancer (BC) and compare their performance.

Materials And Methods: A total of 287 patients with invasive BC in our hospital were retrospectively analyzed. All patients underwent preoperative breast MRI consisting of fat-suppressed T2-weighted imaging, axial dynamic contrast-enhanced MRI, and diffusion-weighted imaging sequences.

View Article and Find Full Text PDF

In this work, N-doped and oxygen vacancy-rich NiCoO/NiO/CoOcomposites are synthesized by the direct calcination method. Noticeably, by changing the additive concentrations of urea dissolved in DMF (N-N dimethylformamide), the electromagnetic wave (EMW) absorption abilities of NiCoO/NiO/CoOcomposite effectively. A maximum reflection loss (RL) value at 12.

View Article and Find Full Text PDF
Article Synopsis
  • Implantable neural devices that record neuron activity offer insights into brain functioning but face challenges during vigorous activities due to brain deformation.* -
  • Effective neural devices need a combination of low modulus, low interfacial impedance, and high electrical conductivity, which currently contradict each other in existing materials.* -
  • A new soft fiber neural device, designed like an axon, successfully tracks individual neurons in active animals by using a conductive gel fiber, achieving optimal properties for stable performance in challenging conditions.*
View Article and Find Full Text PDF
Article Synopsis
  • A strong genetic basis for congenital heart disease (CHD) was highlighted, focusing on BMP4, a gene crucial for heart development; mutations in BMP4 could cause multiple cardiovascular issues and embryonic demise in studies.
  • Researchers sequenced the BMP4 gene in 212 CHD patients and 236 non-CHD individuals, aiming to identify novel mutations and assess their functional consequences.
  • A new mutation, NM_001202.6:c.318T>G;p.(Tyr106*), was discovered in a female with familial CHD, which was linked to CHD in her relatives, and it negatively impacted the expression of key genes affected in CHD cases, suggesting BMP4's role in genetic predisposition to
View Article and Find Full Text PDF
Article Synopsis
  • - This study investigates the resistance levels of the spider mite Tetranychus cinnabarinus to the pesticide fenpropathrin in various field populations in China, highlighting the difference between indoor and outdoor resistance cases.
  • - It finds minimal significant resistance in field populations compared to documented cases indoors and emphasizes the limitations of traditional methods in detecting early resistance, advocating for a combination of bioassays and advanced genetic analysis techniques.
  • - The research suggests that a 5% mutation frequency is critical for resistance development, and while a specific mutation is detected at low rates, the study proposes RNA interference as a promising, environmentally friendly pest control strategy to combat rising resistance threats in agriculture.
View Article and Find Full Text PDF
Article Synopsis
  • Implantable sensors, especially ion sensors, are important for scientific research and personalized healthcare, but permanent implants can pose health risks after their purpose is served.
  • A new biodegradable fiber calcium ion sensor has been developed by bonding ionophores to bioinert nanoparticles, offering a promising alternative to traditional ion-selective membranes.
  • This sensor not only matches the performance and flexibility of conventional sensors but also safely biodegrades over four weeks while maintaining good biocompatibility and reducing leakage concerns regarding harmful substances.
View Article and Find Full Text PDF

This study examines the possible consequence of elder mistreatment on resilience and whether social support moderates this posited association, using a rural sample of 432 community-dwelling older Chinese adults aged 60 to 79 years. Elder abuse included verbal abuse, physical abuse, or financial exploitation. Social support was measured by The Multidimensional Scale of Perceived Social Support (MSPSS).

View Article and Find Full Text PDF
Article Synopsis
  • * Researchers discovered that a protein called AMBRA1 is found in higher amounts in inflamed intestines and helps to increase inflammation.
  • * By removing AMBRA1, they found less inflammation and better results when treating with infliximab, showing that targeting AMBRA1 could help people with difficult cases of IBD.
View Article and Find Full Text PDF

Objective: Aggregating evidence convincingly establishes the predominant genetic basis underlying congenital heart defects (CHD), though the heritable determinants contributing to CHD in the majority of cases remain elusive. In the current investigation, was selected as a prime candidate gene for human CHD mainly due to cardiovascular developmental abnormalities in -knockout animals. The objective of this retrospective study was to identify a new mutation responsible for CHD and characterize the functional effect of the identified CHD-causing mutation.

View Article and Find Full Text PDF

Tetralogy of Fallot (TOF) is the most prevalent cyanotic congenital heart pathology and causes infant morbidity and mortality worldwide. GATA-binding protein 4 (GATA4) serves as a pivotal transcriptional factor for embryonic cardiogenesis and germline mutations are causally linked to TOF. However, the effects of somatic mutations on the pathogenesis of TOF remain to be ascertained.

View Article and Find Full Text PDF

Fiber solar cells as promising wearable power supplies have attracted increasing attentions recently, while further breakthrough on their power conversion efficiency (PCE) and realization of multicolored appearances remain urgent needs particularly in real-world applications. Here, a fiber-dye-sensitized solar cell (FDSSC) integrated with a light diffusion layer composed of alumina/polyurethane film on the outmost encapsulating tube and a light conversion layer made from phosphors/TiO/poly(vinylidene fluoride-co-hexafluoropropylene) film on the inner counter electrode is designed. The incident light is diffused to more surfaces of fiber electrodes, then converted on counter electrode and reflected to neighboring photoanode, so the FDSSC efficiently takes advantage of the fiber shape for remarkably enhanced light harvesting, producing a record PCE of 13.

View Article and Find Full Text PDF

Type 2 diabetes mellitus (T2DM) patients exhibit greater susceptibility to vascular calcification (VC), which has a higher risk of death and disability. However, there is no specific drug for VC therapy. NLRP3 inflammasome activation as a hallmark event of medial calcification leads to arterial stiffness, causing vasoconstrictive dysfunction in T2DM.

View Article and Find Full Text PDF

Aims: To investigate the prevalence of peripheral artery disease (PAD) and diabetic peripheral neuropathy (DPN) and the associated risk factors among Chinese patients with type 2 diabetes mellitus.

Methods: A cross-sectional study was conducted using data between November 1, 2018, and December 31, 2022. PAD was defined as ABI ≤ 0.

View Article and Find Full Text PDF

The extracellular potassium ion concentration in the brain exerts a significant influence on cellular excitability and intercellular communication. Perturbations in the extracellular potassium ion level are closely correlated with various chronic neuropsychiatric disorders including depression. However, a critical gap persists in performing real-time and long-term monitoring of extracellular potassium ions, which is necessary for comprehensive profiling of chronic neuropsychiatric diseases.

View Article and Find Full Text PDF

Background: Rates of overweight and obesity continue to grow in adolescents. Overweight and obesity in adolescence are associated with numerous immediate and long-term adverse health conditions. Throughout adolescence, parents and the family have an important and central influence on adolescents' health and lifestyle.

View Article and Find Full Text PDF

Atrial fibrillation (AF), the most prevalent type of sustained cardiac dysrhythmia globally, confers strikingly enhanced risks for cognitive dysfunction, stroke, chronic cardiac failure, and sudden cardiovascular demise. Aggregating studies underscore the crucial roles of inherited determinants in the occurrence and perpetuation of AF. However, due to conspicuous genetic heterogeneity, the inherited defects accounting for AF remain largely indefinite.

View Article and Find Full Text PDF

Protegrin-1 (PG1) is an antimicrobial peptide (AMP) that has garnered increasing attention due to its potent immune defense activity. Our previous studies demonstrated the ability of PG1 to enhance proliferation and inhibit apoptosis of porcine granulosa cells (GCs) under oxidative stress. GCs play a crucial role in ovary follicular development.

View Article and Find Full Text PDF
Article Synopsis
  • Repairing ligaments with artificial grafts is tough due to the lack of integration with surrounding bone, which leads to instability.
  • Researchers have developed a new high-performance helical composite fiber (HCF) ligament using carbon nanotube sheets around polyester fibers, showing promise in surgical practices.
  • In tests, this HCF ligament not only stimulated effective bone growth but also allowed for normal movement in rats without complications, highlighting its potential for future use in artificial tissue repair.
View Article and Find Full Text PDF

Objective: Efficacy and safety of perampanel monotherapy for treating focal-onset seizures (FOS) has been barely studied in China. This observational study aimed to evaluate the efficacy and safety of perampanel monotherapy in treating Chinese patients with FOS.

Methods: This single-center, prospective, real-world observational study enrolled patients aged ≥4 years with FOS who visited the Epilepsy Out-Patient Clinic of Nanjing Brain Hospital affiliated to Nanjing Medical University from January 2020 to December 2021.

View Article and Find Full Text PDF