Perceived benefits, costs, and relationships on provincial doctors' inclination to participate in urban-rural medical consortia in Central China: a social exchange theory perspective.

Objective: This study aims to investigate the perceived benefits, costs, and relationships that influence doctors' inclination to participate in urban-rural medical consortia (URMC). Furthermore, the study analyzes how perceived relationships moderate the impact of perceived benefits and costs on the inclination to take part in URMC.

Methods: The study was conducted between September 2022 and June 2023 utilizing an online survey in Henan Province, Central China, which included 749 respondents from provincial hospitals.

Incentive affects physicians' willingness to continue participating in urban-rural medical consortia: a comparative study of county and provincial hospitals in Central China.

Objectives: The World Health Organization asserts that incentives significantly impact physicians' participation in healthcare initiatives. China introduced incentive programs to boost involvement in urban-rural medical consortia. However, research is limited on: (a) the effectiveness of these incentives on physicians' willingness to continue participating, (b) disparities in incentive levels between county and provincial hospitals, and (c) the varying impact of incentives on physicians' continued participation in county versus provincial hospitals.

Efficient smart-phone luminescent sensing detection based on new multifunctional Cd(II) luminescent coordination polymers.

Based on the mixed ligand strategy, two new isostructural Cd coordination polymers: {[Cd(tcpa)(bima)(DMF)]‧3DMF} (CP 1), {[Cd(tcpa)(bmima)(DMF)]‧3DMF} (CP 2) were synthesized by combining two flexible anthracene-based and a triphenylamine-based ligands with large π-electron-rich structure using a solvothermal method (Htcpa = tris(4-carboxyphenyl)amine; bima = 9,10-bis(1H-imidazole-1-yl)methyl)anthracene and bmima = 9,10-bis((2-methyl-1H-imidazol-1-yl)methyl)anthracene). CP 1 and CP 2 show an unreported new 3D (3,14)-c net structure with the {4·6·8}{4} topology. Both CPs could detect CrO, Nitroaromatic explosives 2,4,6-Trinitrophenol (TNP) and 2,4-dinitrophenol (DNP) through rapid fluorescence quenching response with high quenching efficiency Ksv and low LOD with 0.

Epigenetic dynamics of aging and cancer development: current concepts from studies mapping aging and cancer epigenomes.

Purpose Of Review: This review emphasizes the role of epigenetic processes as incidental changes occurring during aging, which, in turn, promote the development of cancer.

Recent Findings: Aging is a complex biological process associated with the progressive deterioration of normal physiological functions, making age a significant risk factor for various disorders, including cancer. The increasing longevity of the population has made cancer a global burden, as the risk of developing most cancers increases with age due to the cumulative effect of exposure to environmental carcinogens and DNA replication errors.

Tissue-location-specific transcription programs drive tumor dependencies in colon cancer.

Cancers of the same tissue-type but in anatomically distinct locations exhibit different molecular dependencies for tumorigenesis. Proximal and distal colon cancers exemplify such characteristics, with BRAF predominantly occurring in proximal colon cancers along with increased DNA methylation phenotype. Using mouse colon organoids, here we show that proximal and distal colon stem cells have distinct transcriptional programs that regulate stemness and differentiation.

CD206 modulates the role of M2 macrophages in the origin of metastatic tumors.

Tumor metastasis is a key factor affecting the life of patients with malignant tumors. For the past hundred years, scientists have focused on how to kill cancer cells and inhibit their metastasis , but few breakthroughs have been made. Here we hypothesized a novel mode for cancer metastasis.

Fear of COVID-19 among cancer patients in Henan Province, Central China: causes, results, and coping factors.

Objectives: Cancer patients exhibit fear of COVID-19, which could lead to serious consequences. However, minimal information is available about the effect of the COVID-19 pandemic on the mental health of cancer patients. Therefore, this study aims to examine the fear level of COVID-19 among cancer patients in Henan Province, Central China and to identify its causes, results, and coping factors.

Prognostic value of the geriatric nutritional index in colorectal cancer patients undergoing surgical intervention: A systematic review and meta-analysis.

Background: We reviewed the literature to assess the prognostic ability of the geriatric nutritional risk index (GNRI) for patients with colorectal cancer (CRC) undergoing curative surgery.

Methods: The online databases of PubMed, CENTRAL, ScienceDirect, Embase, and Google Scholar were searched for articles reporting the relationship between GNRI and outcomes in CRC patients. English language studies were searched up to 28 April 2022.

Putative Prevention of XML Injection Against Myocardial Ischemia Is Mediated by PKC and PLA2 Proteins.

Xinmailong (XML) injection is a CFDA-approved traditional Chinese medicine with clinical value for heart failure treatment. The present investigation was aimed to evaluate the potential protective roles of this injection on myocardial ischemia and the underlying molecular mechanism. In our study, we selected two models of myocardial ischemia rats.

Mechanism exploration of ancient pharmaceutic processing (Paozhi) improving the gastroprotective efficacy of Aucklandiae Radix.

Ethnopharmacological Relevance: Processing, also called Paozhi in Chinese, is an ancient Chinese pharmaceutic processing technique developed along with the Chinese herbal medicines (CHMs). The understanding of the mechanism of Paozhi has been investigated for several decades. Aucklandiae Radix (CAR) and its roasted processed products are all used in indigestion as a kind of CHMs.

CIDO-COVID-19: An Ontology for COVID-19 Based on CIDO.

To realize integration, organization and reusability of knowledge related to COVID-19, an ontology for COVID-19 (CIDO-COVID-19) was constructed which extended the Coronavirus Infectious Disease Ontology (CIDO) by adding terms of COVID-19 related to symptoms, prevention, drugs and clinical domains. First, terms from the existing ontologies, literature, clinical guidelines and other resources about COVID-19 were merged. Then, the Stanford seven-step approach was used to define and organize the acquired terms.

Application effect of the principle of seamless management in nursing risk control of the department of gastrointestinal surgery.

Objective: To determine the application effect of nursing risk control based on the principle of seamless management in the department of gastrointestinal surgery.

Methods: A total of 62 patients with gastrointestinal diseases admitted to the Department of Gastrointestinal Surgery in our hospital for nursing risk management based on the principle of seamless management were enrolled into a research group, and another 58 patients admitted before the implementation of such management were enrolled into a control group. The two groups were compared in the incidence of complications, Chinese Perceived Stress Scale (CPSS) score, self-rating anxiety scale (SAS) score, nursing satisfaction, and awareness rate of health knowledge, and the nursing quality scores and medical complaints and disputes were compared before and after the implementation of nursing risk control based on the principle of seamless management by 19 nurses in the department.

Could the connectedness of primary health care workers involved in social networks affect their job burnout? A cross-sectional study in six counties, Central China.

Background: This study aimed to reveal the effects of the connectedness of primary health care (PHC) workers in social networks on their job burnout.

Methods: Cross-sectional survey data of rural PHC workers in China were analyzed. A total of 663 respondents were enrolled.

Overexpression of DUSP6 enhances chemotherapy-resistance of ovarian epithelial cancer by regulating the ERK signaling pathway.

: DUSP6 is a negative regulator of the ERK signaling pathway and plays an important role in chemotherapy-resistance. Previously we showed that DUSP6 is overexpressed in ovarian cancer side population (SP) cells that possess cancer stem cell-like properties and are quiescent and chemotherapy-resistant. Here, we explore the effects of DUSP6 on chemotherapy-resistance by examining its regulation of the ERK signaling pathway and G0/G1 cell cycle arrest.

Job burnout and correlated factors of three-tiered public health workers: A cross-sectional study in China.

This study aimed to reveal burnout levels and its potential influencing factors among three-tiered public health workers in China. A total of 1,328 public health workers from cities, counties and townships in Henan and Hubei provinces participated. Cumulative logistic regressions were used to determine job burnout predictors.

Predictor of sleep difficulty among community dwelling older populations in 2 African settings.

Sleep deprivation is a common phenomenon among older population and is commonly linked to behavioral, physiological, and psychosocial factors. Not much is known about sleep deprivation among older population in Africa. Therefore, in this study we aimed to investigate the basic sociodemographic and psychosocial predictors of self-reported sleep deprivation among older population.

Apoptotic SKOV3 cells stimulate M0 macrophages to differentiate into M2 macrophages and promote the proliferation and migration of ovarian cancer cells by activating the ERK signaling pathway.

Ovarian cancer has a high rate of recurrence, with M2 macrophages having been found to be involved in its progression and metastasis. To examine the relationship between macrophages and ovarian cancer in the present study, M0 macrophages were stimulated with apoptotic SKOV3 cells and it was found that these macrophages promoted tumor proliferation and migration. Subsequently, the mRNAs and proteins expressed at high levels in these M2 macrophages were examined by RNA‑Seq and quantitative proteomics, respectively, which revealed that M0 macrophages stimulated by apoptotic SKOV3 cells also expressed M2 markers, including CD206, interleukin‑10, C‑C motif chemokine ligand 22, aminopeptidase‑N, disabled homolog 2, matrix metalloproteinase 1 and 5'‑nucleotidase.

Stromal vascular fraction promotes migration of fibroblasts and angiogenesis through regulation of extracellular matrix in the skin wound healing process.

Background: A refractory wound is a typical complication of diabetes and is a common outcome after surgery. Current approaches have difficulty in improving wound healing. Recently, non-expanded stromal vascular fraction (SVF), which is derived from mature fat, has opened up new directions for the treatment of refractory wound healing.

Exosomes from Macrophages Exposed to Apoptotic Breast Cancer Cells Promote Breast Cancer Proliferation and Metastasis.

Exosomes have recently become the subject of increasing research interest. Interactions between tumor and host cells via exosomes play crucial roles in the initiation, progression and invasiveness of breast cancer. In our study, we used exosomes isolated from a co-culture model of THP-1-derived macrophages exposed to apoptotic MCF-7 or MDA-MB-231 breast cancer cell line cells to investigate their effects on naïve MCF-7 or MDA-MB-231 cells in vitro and in vivo.

Construction of a sensitive pyrogen-testing cell model by site-specific knock-in of multiple genes.

A pyrogen test is crucial for evaluating the safety of drugs and medical equipment, especially those involved in injections. As existing pyrogen tests, including the rabbit pyrogen test, the limulus amoebocyte lysate (LAL) test and the monocyte activation test have limitations, development of new models for pyrogen testing is necessary. Here we develop a sensitive cell model for pyrogen test based on the lipopolysaccharides (LPS) signal pathway.

Why Patients with Chronic Disease Keep Silent? Analysis of Item Nonresponse in Rural China.

Background: This study aimed to identify the characteristics of item nonresponse and examine the factors affecting the refusal or failure to respond of patients with chronic disease in rural China.

Methods: A cross-sectional survey data from patients with chronic disease from rural China were analyzed. A total of 1,099 patients were enrolled.

Application of a TLR overexpression cell model in pyrogen detection.

Pyrogens are components derived from microorganisms that induce complex inflammatory responses. Current approaches to detect pyrogens are complex and difficult to replicate, thus there is a need for new methods to detect pyrogens. We successfully constructed a pyrogen-sensitive cell model by overexpressing Toll-like receptor (TLR)2, TLR4, MD2, and CD14 in HEK293 cells.

Analysis of Circulating Tumor Cells in Ovarian Cancer and Their Clinical Value as a Biomarker.

Background/aims: Monitoring the appearance and progression of tumors are important for improving the survival rate of patients with ovarian cancer. This study aims to examine circulating tumor cells (CTCs) in epithelial ovarian cancer (EOC) patients to evaluate their clinical significance in comparison to the existing biomarker CA125.

Methods: Immuomagnetic bead screening, targeting epithelial antigens on ovarian cancer cells, combined with multiplex reverse transcriptase-polymerase chain reaction (Multiplex RT-PCR) was used to detect CTCs in 211 samples of peripheral blood (5 ml) from 109 EOC patients.

Tumacrophage: macrophages transformed into tumor stem-like cells by virulent genetic material from tumor cells.

Tumor-associated macrophages are regarded as tumor-enhancers as they have key roles in the subversion of adaptive immunity and in inflammatory circuits that promote tumor progression. Here, we show that cancer cells can subvert macrophages yielding cells that have gained pro-tumor functions. When macrophages isolated from mice or humans are co-cultured with dead cancer cell line cells, induced to undergo apoptosis to mimic chemotherapy, up-regulation of pro-tumor gene expression was identified.

Xinmailong mitigated epirubicin-induced cardiotoxicity via inhibiting autophagy.

Ethnopharmacological Relevance: Using insects, such as the cockroach, for the treatment of disease has a long history in traditional Chinese medicine. Xinmailong (XML) Injection, a bioactive composite extracted from Periplaneta americana (a species of cockroach), shows reasonable protective effects against cardiovascular injury and was approved for the use in the treatment of cardiac dysfunction in 2006, yet its cardio protective mechanisms remain unclear.

Aim: The present study aims to examine the protective effects of XML against epirubicin-induced cardiotoxicity in vivo and determine its underlying mechanisms.