Sono-promoted piezocatalysis and low-dose drug penetration for personalized therapy via tumor organoids.

Chemotherapy is a widely used cancer treatment, however, it can have notable side effects owing to the high-doses of drugs administered. Sonodynamic therapy (SDT) induced by sonosensitizers has emerged as a promising approach to treat cancer, however, there is limited research evaluating its therapeutic effects on human tumors. In this study, we introduced a dual therapy that combines low-dose chemotherapeutic drugs with enhanced sonodynamic therapy, utilizing barium titanate (BaTiO, BTO) nanoparticles (NPs) as sonosensitizers to treat tumor organoids.

Enhanced immune capture of extracellular vesicles with gelatin nanoparticles and acoustic mixing.

Extracellular vesicles (EVs) originating from cancer cells incorporate various critical biomolecules that can aid in early cancer diagnosis. However, the rapid analysis of these micro vesicles remains challenging due to their nano-scale size and overlapping dimensions, hindering sufficient capture in terms of quantity and purity. In this study, an acoustofluidic device was developed to enhance the yield of immune-captured EVs.

Wigner-Smith time delay matrix for acoustic scattering: Theory and phenomenology.

The Wigner-Smith (WS) time delay matrix relates a lossless system's scattering matrix to its frequency derivative. First proposed in the realm of quantum mechanics to characterize time delays experienced by particles during a collision, this article extends the use of WS time delay techniques to acoustic scattering problems governed by the Helmholtz equation. Expression for the entries of the WS time delay matrix involving renormalized volume integrals of energy densities are derived, and shown to hold true, independent of the scatterer's geometry, boundary condition (sound-soft or sound-hard), and excitation.