Publications by authors named "Yiping Tao"

AlkB homolog 5 (ALKBH5) plays an important role in ischemia/reperfusion (I/R), cardiac hypertrophy and other cardiovascular diseases (CVDs). However, whether ALKBH5 regulates the inflammatory response by mediating M1/M2 macrophage conversion after myocardial infarction (MI) is unclear. In this study, we found that ALKBH5 protein expression was significantly downregulated in MI mice.

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Article Synopsis
  • Cell senescence can inhibit oncogene activation, presenting a possible strategy to disrupt tumor cell functions, particularly in ovarian cancer where S1PR1 has been found to play a significant role.* -
  • In ovarian cancer, deleting S1PR1 slows cell growth and movement, promotes senescence, and enhances sensitivity to chemotherapy, particularly cisplatin.* -
  • The study identifies the S1PR1-PDK1-LATS1/2-YAP signaling pathway as a key regulator of ovarian cancer cell senescence, suggesting that targeting this pathway could improve standard treatment outcomes.*
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Background: Aloe-emodin (AE), a natural anthraquinone extract from traditional Chinese medicinal plants, has been certified to protect against acute myocardial ischemia. However, its effect on cardiac remodeling after chronic myocardial infarction (MI) and the possible mechanism remain unclear.

Purpose: This study investigated the effect of AE on cardiac remodeling and oxidative damage induced by myocardial infarction (MI) in vitro and explored the underlying mechanisms.

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The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), the US data center for the global PDB archive and a founding member of the Worldwide Protein Data Bank partnership, serves tens of thousands of data depositors in the Americas and Oceania and makes 3D macromolecular structure data available at no charge and without restrictions to millions of RCSB.org users around the world, including >660 000 educators, students and members of the curious public using PDB101.RCSB.

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The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, rcsb.org), the US data center for the global PDB archive, serves thousands of Data Depositors in the Americas and Oceania and makes 3D macromolecular structure data available at no charge and without usage restrictions to more than 1 million rcsb.org Users worldwide and 600 000 pdb101.

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The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, http://rcsb.org), the US data center for the global PDB archive, makes PDB data freely available to all users, from structural biologists to computational biologists and beyond. New tools and resources have been added to the RCSB PDB web portal in support of a 'Structural View of Biology.

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Article Synopsis
  • - The KB-Rank tool helps users discover the functions of proteins by taking a text query and retrieving relevant protein structures with their functional annotations.
  • - It ranks the structures based on how closely they match the query and the prevalence of annotations across the retrieved structures.
  • - An interactive web interface is available to assist in exploring these results, with examples related to disease topics to showcase the tool's usefulness; it can be accessed at http://protein.tcmedc.org/KB-Rank.
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The Protein Structure Initiative's Structural Biology Knowledgebase (SBKB, URL: http://sbkb.org ) is an open web resource designed to turn the products of the structural genomics and structural biology efforts into knowledge that can be used by the biological community to understand living systems and disease. Here we will present examples on how to use the SBKB to enable biological research.

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The three dimensional atomic structures of proteins provide information regarding their function; and codified relationships between structure and function enable the assessment of function from structure. In the current study, a new data mining tool was implemented that checks current gene ontology (GO) annotations and predicts new ones across all the protein structures available in the Protein Data Bank (PDB). The tool overcomes some of the challenges of utilizing large amounts of protein annotation and measurement information to form correspondences between protein structure and function.

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