Publications by authors named "Yiping Kang"
Article Synopsis
- The immune system plays a crucial role in identifying and destroying tumor cells, primarily through the activation of immune cells like natural killer (NK) cells by interactions between the NKG2D receptor and its ligands (NKG2DLs).
- However, tumors can evade immune detection by shedding soluble NKG2DLs (sNKG2DLs), which are regulated by metalloproteinases and suppress NK cell function and NKG2D receptor expression.
- The review suggests that measuring sNKG2DLs could serve as important biomarkers for cancer progression and may lead to new immunotherapy strategies to enhance treatment effectiveness.
Article Synopsis
- Recent studies indicate that activating brown/beige fat tissues can be an effective way to treat metabolic diseases by increasing energy expenditure.
- Brown/beige adipocytes express uncoupling protein 1 (UCP1), which helps generate heat and combat obesity by speeding up metabolism, especially in cold conditions.
- This study identifies a specific polyphenol that enhances UCP1 activation in fat cells, leading to improved thermogenesis and weight control in animals, suggesting a promising method for obesity treatment through targeting adipose tissue.
Identification of Key Carcinogenic Genes in Colon Adenocarcinoma.
Iran J Public Health
February 2022
Background: We aimed to probe carcinogenic genes associated with colon adenocarcinoma (COAD) development.
Methods: The gene expression profile of COAD were downloaded from TCGA. Differentially expressed genes (DEGs) were identified; GO and KEGG pathway enrichment were analyzed.
Compared to single gemcitabine treatment, the combination of gemcitabine and erlotinib has shown effective response in patients with locally advanced or metastatic pancreatic cancer. However, the combination therapy has not proven effective in patients with pancreatic cancer after R0 or R1 resection. In the present study, a nude mice model of orthotopic xenotransplantation after tumor resection was established using pancreatic cancer cell lines, BxPC-3 and PANC‑1.
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