High-performance and scalable polarization splitter-rotator based on photonic crystal nanobeam reflection.

The polarization splitter-rotator (PSR) is a key device for polarization processing in polarization diversity systems, which has wide applications in achieving polarization independence and mixed multiplexing. However, it remains a significant challenge to simultaneously achieve a better balance in bandwidth, crosstalk (CT), polarization extinction ratio (PER), and compact footprint of the PSR. In this article, a photonic crystal nanobeam (PCN) structure is introduced to PSR for large bandwidth and compact size, with a device length of only 104 µm.

Flexible and reconfigurable integrated optical filter based on tunable optical coupler cascaded with coupled resonator optical waveguide.

Reconfigurable optical filter can satisfy diverse filtering requirements in different application scenarios and shorten development cycle. However, it is still challenging to achieve multi-functional filtering richness with high performance. Here, based on a tunable optical coupler cascaded with a coupled resonator optical waveguide (CROW), a highly flexible and reconfigurable integrated optical filter is proposed and demonstrated on the low-loss silicon nitride platform.

One-step detection of nanoplastics in aquatic environments using a portable SERS chessboard substrate.

Nanoplastics present a significant hazard to both the environment and human health. However, the development of rapid and sensitive analysis techniques for nanoplastics is limited by their small size, lack of specificity, and low concentrations. In this study, a surface-enhanced Raman scattering (SERS) chessboard substrate was introduced as a multi-channel platform for the pre-concentration and detection of nanoplastics, achieved by polydomain aggregating silver nanoparticles (PASN) on a hydrophilic and a punched hydrophobic PVDF combined filter membrane.

Profiling of the Citrus Leaf Endophytic Mycobiota Reveals Abundant Pathogen-Related Fungal Groups.

Plant endophytic microbial communities consist of many latent plant pathogens and, also, many pathogen-related species with reduced virulence. Though with a long history of co-evolution, the diversity and composition of the endophytic mycobiota, especially the pathogen-related fungal groups, has been under-investigated in (). Based on the amplicon sequencing of fungal internal transcribed spacer (ITS), the leaf endophytic mycobiota were profiled on citrus varieties from different citrus-producing regions.

The construction of a maize-teosinte introgression population and quantitative trait loci analysis of their 21 agronomic traits.

Teosinte is a progenitor species of maize (Zea mays ssp. mays) that retains a significant reservoir of genetic resources unaltered via the domestication process. To harness and explore the genetic reservoirs inherent in teosinte, we used the cultivated publicly inbred line H95 and wild species PI566673 (Zea mays ssp.

First Report of Coptis Wilt Disease Caused by in China.

Coptis (Coptis chinensis) belongs to the Ranunculaceae family, the rhizomes used in traditional Chinese medicine. Since 2021, an uncommon stem and leaf wilt disease, with an average disease incidence of 70%~90%, has been observed in Guangdong and Guangxi provinces. The early wilt symptoms were observed on older leaves and stems, and the whole seedling wilted and died.

Continuously tunable silicon waveguide optical switched delay line based on grating-assisted contradirectional coupler.

The integrated optical delay line plays a crucial role in microwave photonic chips. Continuous tunability is a growing trend in filtering and beamforming techniques of microwave photonics. Based on the silicon platform, we present and experimentally demonstrate an integrated continuously optical tunable delay line (OTDL) chip, which contains a 4-bit optical switched delay line (OSDL) and a thermally tunable delay line based on grating-assisted Contradirectional coupler (CDC).

Low loss, wideband, and high extinction ratio TM polarizer based on subwavelength gratings.

We propose a low loss, wideband silicon transverse magnetic (TM) polarizer with high polarization extinction ratio and low reflection based on subwavelength grating. By arranging and optimizing a mutually perpendicular subwavelength grating with different duty cycles as the core and cladding, efficient waveguiding and radiation can be achieved for the TM and transverse electric (TE) injection, respectively. In simulation, the proposed TM polarizer has a footprint of 40µ×16.

Chemically Powered Nanomotors with Magnetically Responsive Function for Targeted Delivery of Exosomes.

Janus structure plays a crucial role in achieving chemically driven nanomotors with exceptional motion performance. However, Janus-structured chemically driven nanomotors with magnetic responsiveness are commonly fabricated by sputtering metal films. In the study, a self-assembly technique is employed to asymmetrically modify the surfaces of magnetic silica (SiO@FeO) nanoparticles with platinum nanoparticles, resulting in the formation of this kind nanomotors.

Ultrahigh extinction ratio and a low power silicon thermo-optic switch.

The silicon thermo-optic switch (TOS) is one of the most fundamental and crucial blocks in large-scale silicon photonic integrated circuits (PICs). An energy-efficient silicon TOS with ultrahigh extinction ratio can effectively mitigate cross talk and reduce power consumption in optical systems. In this Letter, we demonstrate a silicon TOS based on cascading Mach-Zehnder interferometers (MZIs) with spiral thermo-optic phase shifters.

Neurodevelopmental disorders as a risk factor for temporomandibular disorder: evidence from Mendelian randomization studies.

This study aims to clarify the incidence rate of temporomandibular joint disease in patients with mental disorders. Data extracted from the Psychiatric Genomics Consortium and FinnGen databases employed the Mendelian Randomization (MR) method to assess the associations of three neurodevelopmental disorders (NDDs)-Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), and Tourette's Disorder (TD)-as exposure factors with Temporomandibular Disorder (TMD). The analysis used a two-sample MR design, employing the Inverse Variance Weighted (IVW) method to evaluate the relationships between these disorders and Temporomandibular Disorder.

Unveiling the muscle-brain axis: A bidirectional mendelian randomization study investigating the causal relationship between sarcopenia-related traits and brain aging.

Background: Observational studies suggest an association between sarcopenia-related traits and brain aging, but whether this association reflects a causal relationship remains unclear. This study aims to employ Mendelian randomization (MR) methods to investigate the causal impact of sarcopenia-related traits on brain aging.

Methods: This study presents a comprehensive analysis of genome-wide association study (GWAS) summary data associated with sarcopenia-related traits.

Ultrasensitive Detection of Matrix Metalloproteinase 2 Activity Using a Ratiometric Surface-Enhanced Raman Scattering Nanosensor with a Core-Satellite Structure.

Matrix metalloproteinase 2 (MMP-2) has been considered a promising molecular biomarker for cancer diagnosis due to its related dysregulation. In this work, a core-satellite structure-powered ratiometric surface-enhanced Raman scattering (SERS) nanosensor with high sensitivity and specificity to MMP-2 was developed. The SERS nanosensor was composed of a magnetic bead encapsulated within a 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB)-labeled gold shell as the capture core and a 4-mercaptobenzonitrile (MBN)-encoded silver nanoparticle as the signal satellite, which were connected through a peptide substrate of MMP-2.

Fluorescence Super-Resolution Imaging Chip for Gene Silencing Exosomes.

Tumor cell-derived extracellular vesicles and their cargo of bioactive substances have gradually been recognized as novel biomarkers for cancer diagnosis. Meanwhile, the PD-L1 (Programmed Death-Ligand 1) protein, as an immune checkpoint molecule, is highly expressed on certain tumor cells and holds significant potential in immune therapy. In comparison to PD-L1 monoclonal antibodies, the inhibitory effect of PD-L1 siRNA (small interfering RNA) is more advantageous.

Investigation on low-loss hollow-core anti-resonant terahertz fiber.

In this work, a hollow-core anti-resonant terahertz (THz) fiber with elliptical cladding and nested tubes is proposed and fabricated. It is an effective way to reduce the loss of THz waves by transmitting them in an air core and breaking the material absorption. After parameter optimization of the initial structure, multiple transmission windows exist in the 0.

Long-lived SERS Matrix for Real-Time Biochemical Detection Using "Frozen" Transition State.

For the long-time tracking of biological events, maintaining the bioactivity of the analytes during the detection process is essential. Here, we show a versatile surface-enhanced Raman Scattering (SERS) platform, termed a superwettable-omniphobic lubricous porous SERS (SOLP-SERS) substrate. The SOLP-SERS substrate could generate a three-dimensional liquid "hotspots" matrix with an ultra-long lifetime (tens of days) by confining tiny amounts of liquids within the gaps between nanoparticles.

A SERS Composite Hydrogel Device for Point-of-Care Analysis of Neurotransmitter in Whole Blood.

Point-of-care analysis of neurotransmitters in body fluids plays a significant role in healthcare improvement. Conventional approaches are limited by time-consuming procedures and usually require laboratory instruments for sample preparation. Herein, we developed a surface enhanced Raman spectroscopy (SERS) composite hydrogel device for the rapid analysis of neurotransmitters in whole blood samples.

A 3D-printed SERS bionic taster for dynamic tumor metabolites detection.

The variation of tumor-associated metabolites in extracellular microenvironment timely reflects the development, the progression and the treatment of cancers. Conventional methods for metabolite detection lack the efficiency to grasp the dynamic metabolic alterations. Herein, we developed a SERS bionic taster which enabled real-time analysis of extracellular metabolites.

Nanoscale imaging of tumor cell exosomes by expansion single molecule localization microscopy (ExSMLM).

Tumor cell exosomes play a very important role in the process of tumor cell proliferation and metastasis. However, due to the nanoscale size and high heterogeneity of exosomes, in-depth understanding of their appearance and biological characteristics is still lacking. Expansion microscopy (ExM) is a method that embeds biological samples in a swellable gel to physically magnify the samples to improve the imaging resolution.

Grating waveguides by machine learning for augmented reality.

We propose a machine-learning-based method for grating waveguides and augmented reality, significantly reducing the computation time compared with existing finite-element-based numerical simulation methods. Among the slanted, coated, interlayer, twin-pillar, U-shaped, and hybrid structure gratings, we exploit structural parameters such as grating slanted angle, grating depth, duty cycle, coating ratio, and interlayer thickness to construct the gratings. The multi-layer perceptron algorithm based on the Keras framework was used with a dataset comprised of 3000-14,000 samples.

Red Blood Cell Membrane Camouflaged Mesoporous Silica Nanorods as Nanocarriers for Synergistic Chemo-Photothermal Therapy.

In recent years, nanoparticles camouflaged by red blood cell membrane (RBCM) have become a potential nano-drug delivery platform due to their good biocompatibility and immune evasion capability. Here, a multifunctional drug nanocarrier based on RBCM camouflaged mesoporous silica nanorods (MSNR) is presented, which can be used in pH and near-infrared (NIR) light triggered synergistic chemo-photothermal killing of cancer cells. To fabricate such a nanocarrier, MSNR and RBCM were prepared by the sol-gel method and modified hypotonic lysis method, respectively.

Spectra reconfiguration of a silicon microring resonator via double injection with different angles.

A reconfigurable silicon microring filter, which is constructed by cascading a tunable Mach-Zehnder interferometer and a double injected silicon microring resonator with a variable input angle, is proposed and investigated. The spectra reconfigurations of the optical filter were simulated and analyzed using the transmission matrix method. The results show that when keeping the perimeter of the microring constant, the free spectral range (FSR) of the filter can be multiplied by adjusting the angle between the two injections.

Frequency-selectable microwave generation based on on-chip switchable spectral shaping and wavelength-to-time mapping.

We propose and experimentally demonstrate a scheme for the photonic generation of pulsed microwave signals with selectable frequency based on spectral shaping and wavelength-to-time mapping (WTTM) technique. The frequency selectivity is realized by channel switching on an integrated silicon-on-insulator (SOI) spectral shaping chip. The incident signal is spectrally shaped by the asymmetric Mach-Zehnder interferometer (MZI) in the selected channel, and an optical spectrum with uniform free spectral range (FSR) can be generated in a broad bandwidth up to dozens of nanometers, implying large microwave signal duration after WTTM if a pulse light source with matched bandwidth is available.