Publications by authors named "Yipei Wang"

Purpose: The diagnosis and treatment of B-Lineage Acute Lymphoblastic Leukemia (B-ALL) typically rely on cytomorphologic analysis of bone marrow smears. However, traditional morphological analysis methods require manual operation, leading to challenges such as high subjectivity and low efficiency. Accurate segmentation of individual cell nuclei is crucial for obtaining detailed morphological characterization data, thereby improving the objectivity and consistency of diagnoses.

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Chemically synthesized gold nanoantennas possess easy processability, low cost, and suitability for large-area fabrication, making them advantageous for surface-enhanced infrared (SEIRA) biosensing. Nevertheless, current gold nanoantennas face challenges with limited enhancement of biomolecular signals that hinder their practical applications. Here, we demonstrate that the coupling rate between antennas and molecules critically impacts the enhancement of molecular signals based on temporal coupled mode theory.

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Article Synopsis
  • Telemedicine has shown promise as a supplement to traditional care, particularly for conditions like short stature, but more research is needed to determine its effectiveness as a standalone option and its impact on healthcare access.
  • The study analyzed outcomes in 1241 children diagnosed with short stature in China, comparing those receiving only in-person care to those using a combination of in-person and telemedicine services.
  • Results indicated that the telemedicine integrated care group experienced a greater increase in height compared to the in-person care group, highlighting its potential effectiveness in managing this condition.
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  • Grain size is important for rice quality, and while grain length and width are well-studied, the regulation of grain thickness is less understood.
  • Researchers identified a key factor, qGT3, which encodes the OsMADS1 protein, crucial for regulating grain thickness by influencing sugar transport during grain development.
  • A variant of OsMADS1 leads to a shorter protein that enhances sugar uptake in the grain, improving both thickness and quality, and involves other proteins (NF-YB1 and NF-YC12) that work together with OsMADS1 to boost its effectiveness.
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Glycoproteins perform vital functions in numerous biological processes and have important clinical implications. Many glycoproteins have been used as biomarkers and therapeutic targets for disease diagnosis. Due to low concentration of glycoprotein biomarkers and the presence of high-abundance interfering species in biological samples, a selective and sensitive detection method for glycoprotein is essential for real-world applications.

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Grain chalkiness is an undesirable trait that negatively regulates grain yield and quality in rice. However, the regulatory mechanism underlying chalkiness is complex and remains unclear. We identified a positive regulator of white-belly rate (WBR).

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The prowess that makes few-shot learning desirable in medical image analysis is the efficient use of the support image data, which are labelled to classify or segment new classes, a task that otherwise requires substantially more training images and expert annotations. This work describes a fully 3D prototypical few-shot segmentation algorithm, such that the trained networks can be effectively adapted to clinically interesting structures that are absent in training, using only a few labelled images from a different institute. First, to compensate for the widely recognised spatial variability between institutions in episodic adaptation of novel classes, a novel spatial registration mechanism is integrated into prototypical learning, consisting of a segmentation head and an spatial alignment module.

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Introduction: Antenatal care (ANC) is a critical measure to reduce maternal and perinatal morbidity and mortality. However, there are issues of too many visits and cumbersome procedures of ANC in many maternity hospitals of China. In the past 2 years, reduced-visit ANC models combined with remote monitoring have been recommended and implemented at most hospitals in China during the COVID-19 pandemic.

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Objectives: This study aimed to investigate how naringenin (Nar) affected the anti-inflammatory, vascula-rization, and osteogenesis differentiation of human periodontal ligament stem cells (hPDLSCs) stimulated by lipopolysaccharide (LPS) and to preliminarily explore the underlying mechanism.

Methods: Cell-counting kit-8 (CCK8), cell scratch test, and Transwell assay were used to investigate the proliferation and migratory capabilities of hPDLSCs. Alkaline phosphatase (ALP) staining, alizarin red staining, lumen-formation assay, enzyme-linked immunosorbent assay, quantitative timed polymerase chain reaction, and Western blot were used to measure the expression of osteopontin (OPN), Runt-related transcription factor 2 (RUNX2), vascular endothlial growth factor (VEGF), basic fibroblast growth factor (bFGF), von Willebrand factor (vWF), tumor necrosis factor-α (TNF-α), and interleukin (IL)-6.

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A method for preparing new artificial light-harvesting systems (ALHSs) based on supramolecular metallogels was proposed. Various metal ions were introduced into a solution of a bi-benzimidazole compound (P) in ethylene glycol, and P exhibited high selectivity toward Al, as indicated by the noticeable red shift (49 nm) observed in the fluorescence spectra of P after the addition of Al. Interestingly, the gelator, P, could self-assemble into a stable supramolecular gel (P-gel) that exhibits strong aggregation-induced emission in ethylene glycol.

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This paper proposes a strategy for fabricating new artificial light-harvesting systems (ALHSs) based on supramolecular multi-component metallogels. Al was introduced into a solution of an acylhydrazone compound (L) in DMSO or DMF to form the L-Al assembly. After adding Al to the L solution, a noticeable blue shift appeared in the fluorescence spectra of L.

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Hybrid coupling systems consisting of transition metal dichalcogenides (TMD) and plasmonic nanostructures have emerged as a promising platform to explore exciton-plasmon polaritons. However, the requisite cavity/resonator for strong coupling introduces extra complexities and challenges for waveguiding applications. Alternatively, plasmonic nano-waveguides can also be utilized to provide a non-resonant approach for strong coupling, while their utility is limited by the plasmonic confinement-loss and confinement-momentum trade-offs.

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Retrieving waveguiding properties of plasmonic metal nanowires (MNWs) through numerical simulations is time- and computational-resource-consuming, especially for those with abrupt geometric features and broken symmetries. Deep learning provides an alternative approach but is challenging to use due to inadequate generalization performance and the requirement of large sets of training data. Here, we overcome these constraints by proposing a transfer learning approach for modeling MNWs under the guidance of physics.

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Quality is a complex trait that is not only the key determinant of the market value of the rice grain, but is also a major constraint in rice breeding. It is influenced by both genetic and environmental factors. However, the combined effects of genotypes and environmental factors on rice grain quality remain unclear.

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A facile methodology to fabricate a highly elastic organogel for supercapacitors is demonstrated. A stable polymer organogel was obtained in DMSO by a simple esterification reaction. This organogel showed high mechanical performance, flexibility, high elasticity, luminous performance and conductivity, as well as high potential values for application in the energy sector.

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qFC6, a major quantitative trait locus for rice crude fat content, was fine mapped to be identical with Wx. FC6 negatively regulates crude fat content and rice quality. Starch, protein and lipids are the three major components in rice endosperm.

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Article Synopsis
  • The study investigates how naringenin affects the differentiation of bone mesenchymal stem cells (BMSCs) and the role of the SDF-1α/CXCR4 signaling pathway in this process.
  • Results indicate that naringenin promotes BMSC proliferation and enhances osteogenic differentiation markers over time, notably at specific concentrations.
  • The findings suggest that the SDF-1α/CXCR4 signaling axis is involved in naringenin's effects, particularly during the early stages of BMSC differentiation.
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Purpose: For highly operator-dependent ultrasound scanning, skill assessment approaches evaluate operator competence given available data, such as acquired images and tracked probe movement. Operator skill level can be quantified by the completeness, speed, and precision of performing a clinical task, such as biometry. Such clinical tasks are increasingly becoming assisted or even replaced by automated machine learning models.

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In order to prepare a kind of efficient fluorescence sensors for determination of cis-diol-containing flavonoids, novel imprinted quantum dots for myricetin (Myr) were prepared based on boronate affinity-based template-immobilization surface imprinting. The obtained boronate affinity-based surface imprinted silica (imprinted APBA-functionalized CdTe QDs) was used as recognition elements. The quantum dots were used as signal-transduction materials.

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Metal nanowires are attractive building blocks for next-generation plasmonic devices with high performance and compact footprint. The complex reflection coefficients of the plasmonic waveguides are crucial for estimation of the resonating, lasing, or sensing performance. By incorporating physics-guided objective functions and constraints, we propose a simple approach to convert the specific reflection problem of nanowires to a universal regression problem.

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Unlabelled: Chalkiness is one of the key determinants of rice quality and is a highly undesirable trait for breeding and marketing. In this study, , a major quantitative trait locus (QTL) of white-core rate (WCR), was genetically validated using a BCF segregation population and further fine mapped using a near isogenic line (NIL) population, of which both were derived from a cross between the donor parent DL208 and the recurrent parent ZS97. was finally narrowed to a genomic interval of ~ 68 kb, containing seven annotated genes.

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An artificial light-harvesting system (ALHS) has been designed and constructed based on supramolecular organogels made of a simple hydrazide-functionalized benzimidazole derivative (HB), as well as the fluorescent dye rhodamine B (RhB). RhB acted as a good acceptor to realize the energy-transfer process with good efficiency based on a HB/RhB assembly, which showed considerable fluorescence resonance energy transfer (FRET) efficiency of 53% for the energy transfer process. Remarkably, the obtained system showed superior color conversion abilities, converting blue light into orange light.

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Introduction: Naringenin, a dihydro-flavonoid compound that shows chemotactic activity, may have a good application prospect in repairing bone tissue, but its specific mechanism in bone regeneration, especially the osteogenic differentiation of stem cells, needs for a further study. The aim of this study was to investigate the effect of naringenin on the osteogenic differentiation and its roles in the C-X-C chemokine receptor type 4/stromal cell-derived factor 1 (SDF-1/CXCR4) signal pathway of bone marrow-derived mesenchymal stem cells (BMSCs).

Material And Methods: BMSCs were harvested from the femurs and tibias of 4-to-6-week-old male Sprague-Dawley rats.

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In this paper, we consider differentiating operator skill during fetal ultrasound scanning using probe motion tracking. We present a novel convolutional neural network-based deep learning framework to model ultrasound probe motion in order to classify operator skill levels, that is invariant to operators' personal scanning styles. In this study, probe motion data during routine second-trimester fetal ultrasound scanning was acquired by operators of known experience levels (2 newly-qualified operators and 10 expert operators).

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*: Background Consisting of dictated free-text documents such as discharge summaries, medical narratives are widely used in medical natural language processing. Relationships between anatomical entities and human body parts are crucial for building medical text mining applications. To achieve this, we establish a mapping system consisting of a Wikipedia-based scoring algorithm and a named entity normalization method (NEN).

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