Decoding dengue's neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model.

Background: Dengue encephalitis, a severe neurological complication of dengue virus infection, is increasingly recognized for its rising incidence and significant public health burden. Despite its growing prevalence, the underlying mechanisms and effective therapeutic strategies remain poorly understood.

Methods: Cellular atlas of dengue encephalitis was determined by single-nucleus RNA sequencing.