Publications by authors named "Yiou Zhao"
Article Synopsis
- Graft failure and poor graft function present significant challenges in haploidentical hematopoietic stem cell transplantation, particularly for patients with HLA antibodies, and this study explores the role of unrelated umbilical cord blood stem cells as a potential treatment option.
- A total of 90 patients were assessed, divided into three groups based on the presence of HLA antibodies and the use of UCB infusion, with all groups achieving similar recovery times for granulocytes post-transplantation.
- The findings suggest that UCB infusion in HLA antibody-positive patients may lead to better outcomes regarding graft-versus-host disease and overall survival rates compared to those who did not receive UCB support.
Single-level biomarker detection has the limitation of insufficient accuracy in cancer diagnosis. Therefore, the strategy of developing highly sensitive, multi-channel biosensors for high-throughput ctDNA determination is critical to improve the accuracy of early diagnosis of clinical tumors. Herein, in order to achieve efficient detection of up to ten targets for early diagnosis of ovarian cancer, a DNA-nanoswitch-based multi-channel (DNA-NSMC) biosensor was built based on the multi-module catalytic hairpin assembly-mediated signal amplification (CHA) and toehold-mediated DNA strand displacement (TDSD) reaction.
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