Publications by authors named "Yinzhen Pan"
Glioblastoma (GBM) is one of the most lethal human malignancies. The current standard-of-care is highly invasive with strong toxic side effects, leading to poor prognosis and high mortality. As a safe and effective clinical approach, photodynamic therapy (PDT) has emerged as a suitable option for GBM.
View Article and Find Full Text PDFMultidrug-resistant (MDR) bacteria-related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation-induced emission (AIE) molecule BITT-composited bacterial cellulose (BC) is presented as wound dressings.
View Article and Find Full Text PDFMicrobial infections have always been a thorny problem. Multi-drug resistant (MDR) bacterial infections rendered the antibiotics commonly used in clinical treatment helpless. Nanomaterials based on aggregation-induced emission luminogens (AIEgens) recently made great progress in the fight against microbial infections.
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- Polysaccharides (PSY) have various beneficial properties but are not commonly used in food, prompting this study to explore their potential using parts of a Southeast Asian plant.
- The research focused on creating complexes with whey protein concentrate (WPC) from the plant's stem (HCPS) and leaf (HCPL), measuring their stability and antioxidant activities.
- Results indicated that the HCPL-WPC complex displayed greater stability and better antioxidant activity compared to the HCPS-WPC complex, highlighting possibilities for using polysaccharides in food applications.
Article Synopsis
- The study focused on extracting water-soluble natural polysaccharides from Thunb stems using an optimized hot water extraction process, achieving a maximum yield of 2.43%.
- The structural analysis of the extracted polysaccharides revealed a dominant composition of various sugars, with an average molecular weight of approximately 8.854 × 10^3 kDa and specific chemical backbones.
- The extracted polysaccharides demonstrated significant antioxidant activity and inhibited enzymes related to carbohydrate digestion, indicating potential applications for managing blood sugar levels and enhancing food products.
Novel antibacterial agents are urgently needed to control the infections induced by multidrug-resistant (MDR) bacteria. Herein, we rationally designed and facilely synthesized a new D-π-A type luminogen with strong red/near-infrared fluorescence emission, great aggregation-induced emission (AIE) features, and excellent reactive oxygen species (ROS) production. The newly developed molecule TTTh killed the methicillin-resistant Staphylococcus aureus (MRSA) by triggering the ROS accumulation in bacteria and interrupting the membrane integrity.
View Article and Find Full Text PDFMultidrug resistance (MDR) bacteria pose a serious threat to human health. The development of alternative treatment modalities and therapeutic agents for treating MDR bacteria-caused infections remains a global challenge. Herein, a series of near-infrared (NIR) anion-π photosensitizers featuring aggregation-induced emission (AIE-PSs) are rationally designed and successfully developed for broad-spectrum MDR bacteria eradication.
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