Publications by authors named "Yinyu Ma"
Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance (ABC) effect. We design three ionizable oligomers (IOs) that, with polylactide-polyethylene glycol (PLA-PEG), form a potential siRNA delivery system, named Ionizable Polymeric Micelles (IPMs). The siRNA encapsulated IPMs escape from lysosomes upon cellular uptake, and silence the target gene.
View Article and Find Full Text PDFEffects of drug-induced liver injury on the in vivo fate of liposomes.
Eur J Pharm Biopharm
August 2024
Article Synopsis
- Liposomes are highly studied for targeted drug delivery, but their effectiveness can be impacted by liver conditions, which are often overlooked in research.
- This study focused on how drug-induced liver injury (DILI) affects the pharmacokinetics and distribution of liposomes using animal models of liver damage.
- Results showed that liposomes have longer circulation in the blood and greater accumulation in the liver during DILI, with macrophages remaining key players in their uptake, raising both opportunities and concerns for clinical applications in liver-injured patients.