Publications by authors named "Yinying Ni"
Article Synopsis
- Neural stem cell secretome (NSC-S) is shown to be effective in improving neuroprotection and aiding recovery after traumatic brain injury (TBI).
- The study using a male rat model demonstrated that NSC-S treatment alleviates endoplasmic reticulum (ER) stress, reducing neuronal apoptosis associated with TBI.
- Key findings highlight the involvement of the PERK-eIF2α pathway in this process and identify calumenin (CALU) as a potential factor in the neuroprotective effects of NSC-S, suggesting its promise as a treatment for TBI.
Traumatic brain injury (TBI) produces excess iron, and increased iron accumulation in the brain leads to lipid peroxidation and reactive oxygen species (ROSs), which can exacerbate secondary damage and lead to disability and death. Therefore, inhibition of iron overload and oxidative stress has a significant role in the treatment of TBI. Functionalized hydrogels with iron overload inhibiting ability and of oxidative stress inhibiting ability will greatly contribute to the repair of TBI.
View Article and Find Full Text PDFIntracerebral hemorrhage (ICH) is a common subtype of stroke with a very high mortality rate, but there is still no effective cure. Increasing evidence suggests that heme accumulation and neuronal ferroptosis play an important role in secondary injury after ICH. Neural stem cells (NSCs), as seed cells of the central nervous system, have received much attention due to their abundant paracrine product components and low immunogenicity.
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