Novel biomimetic sandwich-structured electrospun cardiac patches with moderate adhesiveness and excellent electrical conductivity.

Clinical cardiac patches exhibit unsatisfied biocompatibility, low adhesion, and inadequate compliance and suboptimal mechanical properties for cardiac disorders repair. To address these challenges, herein we have innovatively proposed a biomimetic nanofiber electrospun membrane with a sandwich structure strategy. The composite patch comprises a stretchable polyurethane (PU) as basic material, then infiltrated with biocompatible silk fibroin methacryloyl (Silk-MA) as the middle layer via electrospinning and finally covered with Bio-ILs (chemically modified biocompatible ionic liquids) to impart electrical conductivity.