Recent advances in the precision control strategy of artificial pancreas.

The scientific diagnosis and treatment of patients with diabetes require frequent blood glucose testing and insulin delivery to normoglycemia. Therefore, an artificial pancreas with a continuous blood glucose (BG) monitoring function is an urgent research target in the medical industry. The problem of closed-loop algorithmic control of the BG with a time delay is a key and difficult issue that needs to be overcome in the development of an artificial pancreas.

Vaginal pH value can affect the susceptibility to human papillomavirus infection.

Background: Cervical cancer is the fourth most common cancer among women, with persistent high-risk human papillomavirus (HPV) infection being responsible for its progression. In healthy, pre-menopausal women, the vaginal pH value is maintained at 3.8-4.

Uterine rupture after high-intensity focused ultrasound ablation of adenomyosis: a case report and literature review.

Aim: High-intensity focused ultrasound (HIFU) is a non-invasive treatment of adenomyosis. Uterine rupture during pregnancy is a rare adverse event after HIFU treatment, because HIFU treatment results in tissue coagulative necrosis.

Methods: We reported a case of uterine rupture in a 34-year-old woman.

A review: The detection of cancer cells in histopathology based on machine vision.

Machine vision is being employed in defect detection, size measurement, pattern recognition, image fusion, target tracking and 3D reconstruction. Traditional cancer detection methods are dominated by manual detection, which wastes time and manpower, and heavily relies on the pathologists' skill and work experience. Therefore, these manual detection approaches are not convenient for the inheritance of domain knowledge, and are not suitable for the rapid development of medical care in the future.

Trends in Surgical Morbidity and Survival Outcomes for Radical Hysterectomy in West China: An 11-Year Retrospective Cohort Study.

Objectives: To vertically analyze the trend of surgical approaches, demographics, surgical morbidity, and long-term survival outcomes of early-stage cervical cancer over the past 11 years and to determine whether there have been any significant changes.

Methods: A total of 851 patients with consecutive International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IA-IIA cervical cancer diagnosed between January 2008 and June 2018 at a single center in China were included in this retrospective study. Trends in the rate of minimally invasive surgery (MIS), demographics, surgical morbidities, and long-term survival outcomes were determined.

Fluorogen-Activating-Protein-Loaded Tantalum Oxide Nanoshells for in Vivo On-Demand Fluorescence/Photoacoustic Imaging.

Optical imaging of targeted compartments within living animals has been widely adopted in many research areas. In particular, various fluorescence-based probes and emerged photoacoustic molecules that enable sensitive and specific imaging through tissue have greatly advanced clinically relevant studies. However, delivery and signal penetration have placed requirements on the performance of conventional optical probes.

GnRH analogue followed by surgery in treatment of vaginal leiomyoma-a case report.

Rationale: Vaginal leiomyoma is a rare type of leiomyoma that occurs on the wall of vagina. Treatment for vaginal leiomyoma is varied and is based on the location and size of the leiomyoma.

Patient Concerns: In this case, a 24-year-old newly married Chinese woman complained of dyspareunia.

Surgical Approach and Use of Uterine Manipulator Are Not Associated with LVSI in Surgery for Early-stage Cervical Cancer.

Study Objective: In 2018, the Laparoscopic Approach to Cervical Cancer trial reported that patients undergoing minimally invasive surgery for cervical cancer (CC) had poorer outcomes than patients undergoing open surgery. Several hypotheses have been made to explain the results. We aimed to investigate whether laparoscopic procedures and use of a uterine manipulator increase the risk of lymphovascular space invasion (LVSI) in early-stage CC.

Novel CFD modeling approaches to assessing urine flow in prostatic urethra after transurethral surgery.

Assessment of the pressure and velocity of urine flow for different diameter ratios of prostatic urethra (RPU) after transurethral surgery using computational fluid dynamics (CFD). A standardized and idealized two-dimensional CFD model after transurethral surgery (CATS-1st) was developed for post-surgery mid-voiding. Using CATS-1st, 210 examples were amplified according to an array of size [3][5][14], which contained three groups of longitudinal diameters of prostatic urethra (LD-PU).

A clinical study to assess the influence of acupuncture at "Wang's Jiaji" acupoints on limb spasticity in patients in convalescent stage of ischemic stroke: study protocol for a randomized controlled trial.

Background: Stroke is characterized by high morbidity, high mortality, and high disability. Spasticity, one of the most common complications after stroke, may reduce the potential success of rehabilitation and has a detrimental effect on stroke patients' daily function and quality of life. Moreover, the long-term management of spasticity is a financial burden to patients and increases societal costs.

Seizure prediction using spike rate of intracranial EEG.

Reliable prediction of forthcoming seizures will be a milestone in epilepsy research. A method capable of timely predicting the occurrence of seizures could significantly improve the quality of life for epilepsy patients and open new therapeutic approaches. Seizures are usually characterized by generalized spike wave discharges.

Epileptic Seizure Detection Using Lacunarity and Bayesian Linear Discriminant Analysis in Intracranial EEG.

Automatic seizure detection plays an important role in long-term epilepsy monitoring, and seizure detection algorithms have been intensively investigated over the years. This paper proposes an algorithm for seizure detection using lacunarity and Bayesian linear discriminant analysis (BLDA) in long-term intracranial EEG. Lacunarity is a measure of heterogeneity for a fractal.

Automatic seizure detection using wavelet transform and SVM in long-term intracranial EEG.

Automatic seizure detection is of great significance for epilepsy long-term monitoring, diagnosis, and rehabilitation, and it is the key to closed-loop brain stimulation. This paper presents a novel wavelet-based automatic seizure detection method with high sensitivity. The proposed method first conducts wavelet decomposition of multi-channel intracranial EEG (iEEG) with five scales, and selects three frequency bands of them for subsequent processing.

Epileptic seizure detection with linear and nonlinear features.

Automatic seizure detection is significant in both diagnosis of epilepsy and relieving the heavy workload of inspecting prolonged EEG. This paper presents a new seizure detection method for multi-channel long-term EEG. The fractal intercept derived from fractal geometry is extracted as a novel nonlinear feature of EEG signals, and the relative fluctuation index is calculated as a linear feature.