Precise diagnosis and prognosis assessment of malignant lung nodules: a narrative review.

Background And Objective: Pulmonary nodules (PNs) are small (≤3 cm) radiographic opacities within lung parenchyma. The use of low-dose computed tomography (LDCT) has led to a significant increase in the identification of solitary nodules. Malignant lung nodules comprise only 5% of all nodules, with management differing greatly from benign cases.

How long can pulmonary resection surgery be performed after SARS-CoV-2 infection? A multicenter retrospective study.

Background: No studies to date have focused on the timing of pulmonary resection in patients with previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the present study, the authors analyzed the surgical outcomes and evaluated the optimal time point of pulmonary resection surgery following SARS-CoV-2 infection.

Materials And Methods: In this multicenter retrospective cohort study, patients were divided into different groups according to the time interval between SARS-CoV-2 diagnosis and pulmonary resection.

Components of the JNK-MAPK pathway play distinct roles in hepatocellular carcinoma.

Purpose: Mitogen-activated protein kinases (MAPK), specifically the c-Jun N-terminal kinase (JNK)-MAPK subfamily, play a crucial role in the development of various cancers, including hepatocellular carcinoma (HCC). However, the specific roles of JNK1/2 and their upstream regulators, MKK4/7, in HCC carcinogenesis remain unclear.

Methods: In this study, we performed differential expression analysis of JNK-MAPK components at both the transcriptome and protein levels using TCGA and HPA databases.

Circulating tumor DNA minimal residual disease in clinical practice of non-small cell lung cancer.

Introduction: The advance of diagnostics and treatments has greatly improved the prognosis of non-small cell lung cancer (NSCLC) patients. However, relapse and metastasis are still common problems encountered by NSCLC patients who have achieved complete remission. Therefore, overcoming the challenge of relapse and metastasis is particularly important for improving the prognosis of NSCLC patients.

Experimental mouse models for translational human cancer research.

The development and growth of tumors remains an important and ongoing threat to human life around the world. While advanced therapeutic strategies such as immune checkpoint therapy and CAR-T have achieved astonishing progress in the treatment of both solid and hematological malignancies, the malignant initiation and progression of cancer remains a controversial issue, and further research is urgently required. The experimental animal model not only has great advantages in simulating the occurrence, development, and malignant transformation mechanisms of tumors, but also can be used to evaluate the therapeutic effects of a diverse array of clinical interventions, gradually becoming an indispensable method for cancer research.

ZNF3 regulates proliferation, migration and invasion through MMP1 and TWIST in colorectal cancer.

Colorectal cancer (CRC) is a malignant tumor with a high incidence and mortality worldwide. Currently, the underlying molecular mechanisms of CRC are still unclear. Zinc finger protein 3 (ZNF3) is a zinc-finger transcription factor that has been reported as a candidate for breast cancer prognosis, suggesting its involvement in the regulation of tumorigenesis.

Clinical Efficacy of Single-Port Thoracoscopic Lobectomy versus Three-Port Thoracoscopic Lobectomy for Lung Cancer.

Objective: To evaluate the clinical efficacy of single-port thoracoscopic lobectomy versus three-port thoracoscopic lobectomy for lung cancer.

Methods: From February 2020 to February 2021, 200 lung cancer patients treated in our institution assessed for eligibility were enrolled and randomly assigned (1 : 1) to either the experimental group (single-port thoracoscopic lobectomy) or the control group (three-port thoracoscopic lobectomy). The outcomes were the eligible patients' surgical indices, pain stress indexes, and postoperative complications.

Immune Response-Related Genes - and Polymorphisms in Lung Cancer: A Case-Control Study in China.

Purpose: This study aimed to evaluate the associations between immune response-related genes - and polymorphisms and risk of lung cancer.

Methods: Seven polymorphisms of and were genotyped in 350 cases and 350 controls using a MassARRAY platform.

Results: The rs1400656-G and rs7574865-T alleles may decrease the susceptibility to lung cancer ( = 0.

Selective phenol hydrogenation to cyclohexanone over a dual supported Pd-Lewis acid catalyst.

Cyclohexanone is an industrially important intermediate in the synthesis of materials such as nylon, but preparing it efficiently through direct hydrogenation of phenol is hindered by over-reduction to cyclohexanol. Here we report that a previously unappreciated combination of two common commercial catalysts-nanoparticulate palladium (supported on carbon, alumina, or NaY zeolite) and a Lewis acid such as AlCl3-synergistically promotes this reaction. Conversion exceeding 99.

Effect of pressure on the selectivity for the esterification of ethylene glycol with propionic acid in supercritical CO2.

The esterification of ethylene glycol with propionic acid was investigated in supercritical CO2 at 50.0 degrees C. The effect of pressure on equilibrium conversion and selectivity of ethylene glycol monopropionate (monoester) and ethylene glycol dipropinonate (diester) was studied systematically.