Scutellarein inhibits lung cancer growth by inducing cell apoptosis and inhibiting glutamine metabolic pathway.

Ethnopharmacological Relevance: Scutellaria baicalensis Georgi, a widely used Chinese medicinal herb, has shown effectiveness against lung cancer. Scutellarein, a key component of Scutellaria baicalensis, also demonstrates anticancer properties in lung cancer. However, the underlying mechanisms have not yet been clarified.

Efficient removal of ammonia-nitrogen in wastewater by zeolite molecular sieves prepared from coal fly ash.

Zeolite molecular sieves are potential adsorbents for wastewater treatment, characterized by high efficiency, simple process, easy regeneration, and low treatment cost. In this study, zeolite A molecular sieves were prepared using coal fly ash (CFA), which is an effective method for the utilization of CFA. The results showed that the CFA-based zeolite molecular sieves synthesized under optimized conditions exhibited excellent adsorption and removal rates (> 40%) for ammonia-nitrogen in wastewater of different concentrations and properties.

High Affinity and FAP-Targeted Radiotracers: A Potential Design Strategy to Improve the Pharmacokinetics and Tumor Uptake for FAP Inhibitors.

Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts, making it an attractive target for both imaging and therapy of malignancy. This study presents a range of novel FAP inhibitors derived from amino derivatives of UAMC1110, incorporating polyethylene glycol and bulky groups containing bifunctional DOTA chelators. The compounds labeled with gallium-68 were developed and characterized to study biodistribution properties and tumor-targeting performance in nude mice bearing U87MG tumor xenografts.

The effects of novel macrocyclic chelates on the targeting properties of the Ga-labeled Gastrin releasing peptide receptor antagonist RM2.

Background: The gastrin-releasing peptide receptor (GRPr) is a molecular target for the visualization of prostate cancer. Bombesin (BN) analogs are short peptides with a high affinity for GRPr. RM2 is a bombesin-based antagonist.

Improve the Biodistribution with Bulky and Lipophilic Modification Strategies on Lys-Urea-Glu-Based PSMA-Targeting Radiotracers.

Since prostate-specific membrane antigen (PSMA) is upregulated in nearly all stages of prostate cancer (PCa), PSMA can be considered a viable diagnostic biomarker and treatment target in PCa. In this study, we have developed five Ga-labeled PSMA-targeted tracers, Ga-Flu-1, Ga-Flu-2, Ga-9-Ant, Ga-1-Nal, and Ga-1-Noi, to investigate the effect of lipophilic bulky groups on the pharmacokinetics of PSMA inhibitors compared to Ga-PSMA-11 and then explore their in vitro and in vivo properties. Ga-labeled PSMA inhibitors were obtained in 88.

Predictors of As-Needed Ranibizumab Injection Frequency in Patients With Macular Edema Following Retinal Vein Occlusion.

Purpose: To evaluate spectral-domain optical coherence tomography (SD-OCT) biomarkers associated with ranibizumab injection frequency after 7 monthly doses in the prospective, multicenter SHORE study for macular edema due to retinal vein occlusion (RVO).

Design: Prospective phase IV clinical trial data.

Methods: Post hoc analysis of 95 patients who received 7 monthly doses of ranibizumab followed by either pro re nata (PRN) or nonrandomized monthly injections from months 7-15 in eyes with macular edema secondary to RVO.

LncRNA promotes the malignant progression of colorectal cancer by regulating the miR-214-5p-JAG1 axis.

Background: Long non-coding RNAs (lncRNAs) have recently been found to be vital regulators of various cancers, including colorectal cancer (CRC). It has been previously reported that the dysregulated expression of lncRNA Five prime to Xist () is involved in carcinogenesis. However, the role of lncRNA in the progression of CRC is still unclear.

In vitro and in vivo comparative study of a novel Ga-labeled PSMA-targeted inhibitor and Ga-PSMA-11.

Ga-radiolabeled small molecules that specifically target prostate-specific membrane antigen (PSMA) have been extensively investigated, and some of these tracers have been used in the diagnosis of prostate cancer via Ga-positron emission tomography (Ga-PET). Nevertheless, current Ga-labeled radiotracers show only fair detection rates for metastatic prostate cancer lesions, especially those with lower levels of prostate specific antigen (PSA), which often occurs in the biochemical recurrence of prostate cancer. The goal of this study was to design and synthesize a new PSMA-targeted radiotracer, Ga-SC691, with high affinity for prostate cancer cells and excellent pharmacokinetics.

Quantitative Fundus Autofluorescence in Rhesus Macaques in Aging and Age-Related Drusen.

Purpose: To employ quantitative fundus autofluorescence (qAF) imaging in rhesus macaques to noninvasively assess retinal pigment epithelial (RPE) lipofuscin in nonhuman primates (NHPs) as a model of aging and age-related macular degeneration (AMD).

Methods: The qAF imaging was performed on eyes of 26 rhesus macaques (mean age 18.8 ± 8.

Spectral-Domain OCT Predictors of Visual Outcomes after Ranibizumab Treatment for Macular Edema Resulting from Retinal Vein Occlusion.

Purpose: To evaluate spectral-domain (SD)-OCT features associated with baseline vision and visual outcomes in the prospective, multicenter Study Evaluating Dosing Regimens for Treatment with Intravitreal Ranibizumab Injections in Subjects with Macular Edema following Retinal Vein Occlusion (SHORE).

Design: Post hoc analysis of prospective clinical trial data.

Participants: Two hundred two participants in the 15-month, phase 4 SHORE study comparing monthly versus pro re nata ranibizumab after 7 monthly doses in eyes with retinal vein occlusion (RVO) with macular edema.