miR-122/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis.

Background/aims: MicroRNAs (miRNAs) are involved in the pathogenesis of osteoarthritis (OA). The present study aimed to investigate the potential function of miR-122 in the development of OA and its potential molecular mechanisms.

Methods: The expression of miR-122, silent information regulator 1 (SIRT1), collagen II, aggrecan, matrix metalloproteinase (MMP) 13 (MMP13) and ADAMTS4 in OA cartilage was detected by RT-qPCR.

Treatment of the distal fracture in radioulna based on the volar wrist dual channel approach and postoperative X-ray diagnosis.

The fracture of the distal ulna and radius is a kind of fracture that results in high morbidity and occurrence rate and contributes to about one-sixth of the entire body's fracture. In this study, we implemented the improved palmar wrist surgery by a volar wrist dual channel approach. Between 2011 and 2014, we have treated 67 distal radius fracture patients.