Publications by authors named "Yinuo Ping"
Polygonatum sibiricum polysaccharides (PSP) has been shown to possess multiple pharmacological functions. Our previous study found that PSP could protect against acute liver injury during sepsis via inhibiting inflammatory response. However, the underlying molecular mechanism by which PSP alleviates septic acute liver injury (SALI) remains unknown.
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- RORγt is a key protein that helps in the development of Th17 cells, which are important for regulating the immune response and are linked to autoimmune diseases.
- Inverse agonists that target RORγt can potentially treat these autoimmune conditions, with GSK2981278 being one such compound that unfortunately failed due to poor stability in the body.
- Researchers developed new sulfonamide derivatives, including b14, which showed better stability and successfully suppressed IL-17A levels in a mouse model of skin inflammation, suggesting promise for therapeutic use.