Due to the low permeability of shales, drilling fluid filtrate is very likely to intrude into the formation along the nanomicron pore joints of shale, leading to microfracture expansion and causing a well wall destabilization phenomenon. Based on the characteristics of the formation shale, a new nano plugging agent, styrene (St)/2-acrylamido-2-methylpropanesulfonic acid (AMPS)/ethyl acrylate (EA), was synthesized by emulsion polymerization using St, EA, and AMPS as reaction monomers. The analysis results using infrared spectroscopy and transmission electron microscopy showed that the product met the expected design.
View Article and Find Full Text PDFEpstein-Barr virus (EBV), a common gamma herpesvirus, establishes a life-long latent infection in the host to defend against innate immune recognition, which is closely related to a variety of malignant tumors, but its specific mechanism is unclear. BFRF3, an EBV-encoded small capsid protein, is mainly involved in the assembly of the viral capsid structure and the maintenance of its stability. Here, we showed that BFRF3 can inhibit TNF-α-mediated NF-кB promoter activation.
View Article and Find Full Text PDFIn this study, a new polyionic polymer inhibitor, TIL-NH, was developed to address the instability of shale gas horizontal wells caused by water-based drilling fluids. The structural characteristics and inhibition effects of TIL-NH on mud shale were comprehensively analyzed using infrared spectroscopy, NMR spectroscopy, contact angle measurements, particle size distribution, zeta potential, X-ray diffraction, thermogravimetric analysis, and scanning electron microscopy. The results demonstrated that TIL-NH significantly enhances the thermal stability of shale, with a decomposition temperature exceeding 300 °C, indicating excellent high-temperature resistance.
View Article and Find Full Text PDFEpstein-Barr virus (EBV) infects host cells and establishes a latent infection that requires evasion of host innate immunity. A variety of EBV-encoded proteins that manipulate the innate immune system have been reported, but whether other EBV proteins participate in this process is unclear. EBV-encoded envelope glycoprotein gp110 is a late protein involved in virus entry into target cells and enhancement of infectivity.
View Article and Find Full Text PDFEpstein-Barr virus (EBV) is a member of the lymphotropic virus family and is highly correlated with some human malignant tumors. It has been reported that envelope glycoprotein 110 (gp110) plays an essential role in viral fusion, DNA replication, and nucleocapsid assembly of EBV. However, it has not been established whether gp110 is involved in regulating the host's innate immunity.
View Article and Find Full Text PDFProc ACM SIGMOD Int Conf Manag Data
January 2019
Labeling training data is one of the most costly bottlenecks in developing machine learning-based applications. We present a first-of-its-kind study showing how existing knowledge resources from across an organization can be used as weak supervision in order to bring development time and cost down by an order of magnitude, and introduce Snorkel DryBell, a new weak supervision management system for this setting. Snorkel DryBell builds on the Snorkel framework, extending it in three critical aspects: flexible, template-based ingestion of diverse organizational knowledge, cross-feature production serving, and scalable, sampling-free execution.
View Article and Find Full Text PDFZero drift can severely deteriorate the stability of the light-dark current ratio, detectivity, and responsivity of photodetectors. In this paper, the effects of a [6,6]-phenyl-C61-butyric acid methyl ester (PCBM)-doped perovskite-based photodetector device on the inhibition of zero drift under dark state are discussed. Two kinds of photodetectors (Au/CHNHPbICl/Au and Au/CHNHPbICl:PCBM/Au) were prepared, and the materials and photodetector devices were measured by scanning electron microscopy, X-ray diffraction, photoluminescence, ultraviolet absorption spectra, and current-voltage and current-time measurements.
View Article and Find Full Text PDFRecent studies have suggested that FSH plays an important role in ovarian epithelial carcinogenesis. We demonstrated that FSH stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis and facilitates neovascularisation. Our previous work has shown that transient receptor potential channel C3 (TRPC3) contributes to the progression of human ovarian cancer.
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