Urgent one-stage endoscopic treatment for choledocholithiasis related moderate to severe acute cholangitis: A propensity score-matched analysis.

Background: During emergency endoscopic retrograde cholangiopancreatography (ERCP), the safety and feasibility of performing one-stage endoscopic treatment for patients with acute cholangitis (AC) due to choledocholithiasis are unclear.

Aim: To investigate the safety and feasibility of one-stage endoscopic treatment for moderate to severe AC.

Methods: We enrolled all patients diagnosed with moderate to severe cholangitis due to common bile duct stones from January 2019 to July 2023.

Digital cholangioscopy-assisted, direct visualization-guided, radiation-free, endoscopic retrograde intervention for cholelithiasis: technical feasibility, efficacy, and safety.

Background: Nonradiation, digital cholangioscope (DCS)-assisted endoscopic intervention for cholelithiasis has not been widely performed. For this study, we aimed to report the feasibility, efficacy, and safety of an established DCS-guided lithotomy procedure.

Methods: Data relating to biliary exploration, stone clearance, adverse events, and follow-up were obtained from 289 patients.

Radiation-free endoscopic papillectomy for ampullary adenoma: experience from a Chinese tertiary hospital.

Background: Conventional endoscopic papillectomy (ESP) for ampullary adenoma is performed as a hybrid endoscopy and fluoroscopy guided procedure. In this study, we report our preliminary experience of non-radiation ESP.

Methods: The present method includes endoscopic snare resection, non-radiation endoscopic biliary and pancreatic stenting and endoclipping.

Photodynamic therapy for hepatic hilar intraductal papillary neoplasm of the bile duct: a case report.

Video 1Photodynamic therapy for hepatic hilar intraductal papillary neoplasm of the bile duct: a case report.

Radiation-free digital cholangioscopy-guided laser lithotripsy for large common bile duct stones: feasibility and technical notes.

Aims: Although endoscopic retrograde cholangiopancreatography (ERCP) for large common bile duct (CBD) stones is facilitated by digital cholangioscopy-guided lithotripsy, it is performed by fluoroscopy guidance. Here, we report our experience of non-radiation ERCP for large CBD stones using digital cholangioscopy-guided laser lithotripsy.

Methods: Sixteen patients with large CBD stones underwent non-radiation digital cholangioscopy-guided laser lithotripsy and lithotomy.

Design, Synthesis, and Biological Evaluation of Organic Nitrite (NO) Donors as Potential Anticerebral Ischemia Agents.

The treatment of ischemic stroke (IS) remains a big challenge in clinics, and it is urgently needed to develop novel, safe, and effective medicines against IS. Here, we report the design, synthesis, and biological evaluation of organic NO donors as potential agents for the treatment of IS. The representative compound was able to slowly generate low concentrations of NO by reaction with a thiol-containing nucleophile, and the NO was selectively converted into NO under ischemic/hypoxia conditions to protect primary rat neurons from oxygen-glucose deprivation and recovery (OGD/R)-induced cytotoxicity by enhancing the Nrf2 signaling and activating the NO/cGMP/PKG pathway.

Evaluation of 18F-DCFPyL PSMA PET/CT for Prostate Cancer: A Meta-Analysis.

Background: To systematically review the clinical value of 18F-DCFPyL prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) in the diagnosis of prostate cancer (PCa).

Methods: Literature concerning 18F-DCFPyL PSMA PET/CT in the diagnosis of prostate cancer published from 2015 to 2020 was electronically searched in the databases including PubMed and Embase. Statistical analysis was carried out with STATA 15 software, and the quality of included studies was tested with quality assessment of diagnostic accuracy studies (QUADAS) items.

Design, synthesis, and biological evaluation of ligustrazine/resveratrol hybrids as potential anti-ischemic stroke agents.

To search for potent anti-ischemic stroke agents, a series of tetramethylpyrazine (TMP)/resveratrol (RES) hybrids 6a-t were designed and synthesized. These hybrids inhibited adenosine diphosphate (ADP)- or arachidonic acid (AA)-induced platelet aggregation, among them, 6d, 6g-i, 6o and 6q were more active than TMP. The most active compound 6h exhibited more potent anti-platelet aggregation activity than TMP, RES, as well as positive control ticlopidine (Ticlid) and aspirin (ASP).

Glutathione S-Transferase π-Activatable O-(Sulfonylethyl Derived) Diazeniumdiolates Potently Suppress Melanoma in Vitro and in Vivo.

A group of glutathione S-transferase π (GSTπ) activatable O-(sulfonylethyl derived) diazeniumdiolates 5-12 were designed and synthesized. These compounds could be activated by GSTπ to initiate the β-elimination reaction, liberating an active vinyl sulfone-based GSH derivative and a diazeniumdiolate anion which subsequently releases NO in situ. The most active compound 6 released relatively high levels of NO and inhibited proliferation of melanoma B16 cells, superior to a diazeniumdiolate-based anticancer agent JS-K (1).

Characterization of cadmium ((108)Cd) distribution and accumulation in Tagetes erecta L. seedlings: effect of split-root and of remove-xylem/phloem.

Tagetes erecta has a high potential for cadmium (Cd) phytoremediation. Through several hydroponic experiments, characteristics of (108)Cd distribution and accumulation were investigated in T. erecta with split -roots or removed xylem/phloem.

Ageing behavior of phenanthrene and pyrene in soils: a study using sodium dodecylbenzenesulfonate extraction.

The surfactant SDBS has potential to be used as an extractant in advanced extraction methods. It was investigated if SDBS in concentrations of 10,000 mg L(-1) can be used to study the ageing behaviors of phenanthrene and pyrene in two soils. Compared to dichloromethane extraction, extraction with 10,000 mg L(-1) SDBS can improve the precision of the determination due to the low volatility of surfactant solution.

Investigation on the photocatalytic degradation of pyrene on soil surfaces using nanometer anatase TiO2 under UV irradiation.

Photocatalytic degradation of pyrene on soil surfaces was investigated in the presence of nanometer anatase TiO(2) under a variety of conditions. After being spiked with pyrene, soil samples loaded with different amounts of TiO(2) (0%, 1%, 2%, 3%, and 4%, w/w) were exposed to UV irradiation for 25h. The results indicated that the photocatalytic degradation of pyrene followed pseudo-first-order kinetics.

Effects of aging and freeze-thawing on extractability of pyrene in soil.

The effects of soil freezing and thawing on the extractability by dichloromethane of pyrene from two Chinese soils are investigated. The soils were collected from the Northeast region of China where heavy pollution of soils by Polycyclic Aromatic Hydrocarbons (PAH) is common. Two soils were considered: a burozem obtained from the Shenfu irrigated region in Liaoning province and a phaeozem collected from the Hailun area in Haerbin province.