Inhibitor of Wnt receptor 1 suppresses the effects of Wnt1, Wnt3a and β‑catenin on the proliferation and migration of C6 GSCs induced by low‑dose radiation.

The radioresistance of glioma is an important cause of treatment failure and tumor aggressiveness. In the present study, under performed with linear accelerator, the effects of 0.3 and 3.

LH upregulates connexin 43 expression in granulosa cells by activating the Wnt/β-catenin signalling pathway.

Connexin (Cx) 43 is the most widely expressed gap junction protein in follicle granulosa cells and plays an important role in follicle development and growth. The aims of this study were to investigate the effects of LH on the expression of Cx43 and key proteins in the downstream Wnt-β/catenin signalling pathway and to explore the mechanism underlying the regulation of Cx43 expression in granulosa cells. Primary culture granulosa cells were obtained from 21-day-old Sprague-Dawley rats, and were treated with different concentrations of LH (150, 300 and 600 IU L-1).

N-methyl-D-aspartate receptor subunit 1 regulates neurogenesis in the hippocampal dentate gyrus of schizophrenia-like mice.

N-methyl-D-aspartate receptor hypofunction is the basis of pathophysiology in schizophrenia. Blocking the N-methyl-D-aspartate receptor impairs learning and memory abilities and induces pathological changes in the brain. Previous studies have paid little attention to the role of the N-methyl-D-aspartate receptor subunit 1 (NR1) in neurogenesis in the hippocampus of schizophrenia.

In-Fiber Closed Cavity Interferometric High-Resolution Aqueous Solution and Alcohol Gas Refractometer.

An optical fiber interferometric refractometer for alcohol gas concentration and low refractive index (RI) solution (with 1.33-1.38 RI range) measurement is theoretically and experimentally demonstrated.

Polarization dependence of a graphene-optical fiber hybrid Mach-Zehnder interferometer.

Graphene exhibits a particular optical polarization dependence property, which is that supporting optical polarization states of graphene can be readily altered through tuning the polarity of the imaginary part of its conductivity. The in-fiber Mach-Zehnder interferometer (MZI) possesses extremely high sensitivity to the surrounding refractive index through cladding modes. Combining graphene and the in-fiber interferometer, a graphene-optical fiber hybrid MZI is constructed.

Expression of NR1 and apoptosis levels in the hippocampal cells of mice treated with MK‑801.

The aim of the present study was to investigate the characteristics of N‑methyl‑D‑aspartate receptor R1 (NR1) expression and apoptosis in the nerve cells of the hippocampus in schizophrenia‑like mice. C57BL/6 mice were randomly allocated to the following groups: i) Blank group; ii) MK‑801 group; iii) MK‑801+NMDA group, according to body weight. The NMDAR antagonist, MK‑801 (0.

Effects of single and repeated electroconvulsive stimulation on hippocampal cell proliferation and spontaneous behaviors in the rat.

Electroconvulsive therapy (ECT) has therapeutic effects on refractory depression and schizophrenia, although its biological mechanisms are still unclear. Recent studies in rodents suggest that electroconvulsive stimulation-induced seizures (ECSs) influence hippocampal adult neurogenesis, which has gained considerable traction as a possible cellular substrate for the treatment of depression. The aim of this study is to explore alteration of neurogenesis in the hippocampus following ECSs and the relationship between neurogenesis and behavior in rats.