[Down-regulated βIII-tubulin expression can reverse paclitaxel resistance in A549/taxol cells lines].

Background: Chemotherapy drug resistance is the primary causes of death in patients with pulmonary carcinoma which make tumor recurrence or metastasis. β-tubulin is the main cell targets of anti-microtubule drug. Increased expression of βIII-tubulin has been implicated in non-small cell lung cancer (NSCLC) cell lines.

Correlation study and significance of the EGFR expression in serum, lymph nodes and tumor tissue of NSCLC.

Background: This study was designed to detect the protein expression of epidermal growth factor receptor (EGFR) among serum, lymph node, and tumor tissues, and to discuss their relationship and clinical significance. We investigated whether EGFR levels in serum and lymph nodes could be used as an effective method for non-small cell lung cancer (NSCLC) to diagnose and assess clinical stage.

Methods: In 56 patients with NSCLC and 10 individuals with nonmalignant thoracic disease, we measured EGFR levels in serum using an enzyme immunoassay, and EGFR mRNA levels in lymph node and NSCLC tissues by quantitative real-time-polymerase chain reaction.

[The correlation between the expression of EGFR in tumor tissue and in peripheral blood in non-small cell lung cancer patients].

Background And Objective: it has been proven that EGFR plays an important role in cell proliferation, and has predictive values for diagnosis and prognosis. The aim of this study is to investigate the correlation between the expression of EGFR in tumor tissue and peripheral blood in non-small cell lung cancer (NSCLC) patients.

Methods: the expression of EGFR was analyzed by real-time RT-PCR in 46 NSCLC tumor tissues and by ELISA in peripheral blood, compared with 10 patients with benign pulmonary diseases as control.