TRIM35 Negatively Regulates the cGAS-STING-Mediated Signaling Pathway by Attenuating K63-Linked Ubiquitination of STING.

The cGAS-STING-mediated antiviral response plays an important role in the defense against DNA virus infection. Tripartite motif protein 35 (TRIM35), an E3 ubiquitin ligase, was identified as a positive regulator of RLR-mediated antiviral signaling in our previous study, but the effect of TRIM35 on the cGAS-STING signaling pathway has not been elucidated. Herein, we showed that TRIM35 negatively regulates the cGAS-STING signaling pathway by directly targeting STING.

Stability Analysis of Fractional Bidirectional Associative Memory Neural Networks With Multiple Proportional Delays and Distributed Delays.

This article investigates the finite-time stability of a class of fractional-order bidirectional associative memory neural networks (FOBAMNNs) with multiple proportional and distributed delays. Different from the existing Gronwall integral inequality with single proportional delay ( ), we establish the Gronwall integral inequality with multiple proportional delays for the first time in the case of . Since the existing fractional-order single-constant delay Gronwall inequality with two different orders cannot be directly applied to the stability analysis of the aforementioned system, initially, we skillfully develop a novel one with generalized fractional multiproportional delays' Gronwall inequalities of different orders.