Temperature and initial composition dependence of pattern formation and dynamic behavior in phase separation under deep-quenched conditions.

Phase separation of SCN-HO ([CHCN]-HO) transparent solutions is simulated in two dimensions and the effects of quenching temperature and initial composition on the pattern formation and dynamic behavior of the second phase are examined Minkowski functionals. The simulation is based on model H where the molar free energy of the SCN-HO solution is obtained by the CALPHAD approach. We find that the composition and temperature do not affect the exponent in the domain growth law, where the average domain size with time yields ()- .

CLIC4, ERp29, and Smac/DIABLO derived from metastatic cancer stem-like cells stratify prognostic risks of colorectal cancer.

Purpose: Cancer stem-like cells have been well accepted to be involved in recurrence and metastasis of cancers, but the prognostic potential of biomarkers integrating with metastasis and cancer stem-like cells for colorectal cancer is unclear.

Experimental Design: We identified three proteins, CLIC4, ERp29, and Smac/DIABLO, from metastatic cancer stem-like cells of colorectal cancer and verified the proteins' role in metastatic behaviors. The proteins were detected by IHC in colorectal cancer tumors and matched colonic mucosa from patients with colorectal cancer who underwent radical surgery in the training cohort.