Publications by authors named "Yinkuang Qi"
Article Synopsis
- - A systematic review and meta-analysis were conducted to determine factors affecting leptomeningeal collateral status in patients with acute ischemic stroke, analyzing 81 studies with over 17,000 participants.
- - The analysis identified that older age, male sex, hypertension, diabetes, atrial fibrillation, cardioembolic stroke, internal carotid artery occlusion, and high admission blood glucose negatively impacted collateral status.
- - The study suggests that hypertension and diabetes could be modified to improve outcomes in stroke patients, while older age and male sex are inherent risk factors that cannot be changed; further studies are recommended to explore treatment strategies.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motor neuron loss and gliosis in the spinal cord, brain stem and cortex. The Notch signaling pathway has been reported to be dysfunctional in neurodegenerative diseases, including ALS. However, the exact mechanism is still unclear.
View Article and Find Full Text PDFMutant SOD1 causes amyotrophic lateral sclerosis (ALS) by a dominant gain of toxicity. Previous studies have demonstrated therapeutic potential of mutant SOD1-RNAi delivered by intrathecal (IT) injection of recombinant adeno-associated virus (rAAV). However, optimization of delivery is needed to overcome the high degree of variation in the transduction efficiency and therapeutic efficacy.
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