Use of CT-derived radiomic features to preoperatively identify invasive mucinous adenocarcinoma in solitary pulmonary nodules ≤3 cm.

Objective: In this study, we aimed to utilize computed tomography (CT)-derived radiomics and various machine learning approaches to differentiate between invasive mucinous adenocarcinoma (IMA) and invasive non-mucinous adenocarcinoma (INMA) preoperatively in solitary pulmonary nodules (SPN) ≤3 cm.

Methods: A total of 538 patients with SPNs measuring ≤3 cm were enrolled, categorized into either the IMA group (n = 50) or INMA group (n = 488) based on postoperative pathology. Radiomic features were extracted from non-contrast-enhanced CT scans and identified using the least absolute shrinkage and selection operator (LASSO) algorithm.

Quantification of Intratumoral Heterogeneity: Distinguishing Histological Subtypes in Clinical T1 Stage Lung Adenocarcinoma Presenting as Pure Ground-Glass Nodules on Computed Tomography.

Rationale And Objectives: To quantify intratumor heterogeneity (ITH) in clinical T1 stage lung adenocarcinoma presenting as pure ground-glass nodules (pGGN) on computed tomography, assessing its value in distinguishing histological subtypes.

Materials And Methods: An ITH score was developed for quantitative measurement by integrating local radiomics features and global pixel distribution patterns. Diagnostic efficacy in distinguishing histological subtypes was evaluated using receiver operating characteristic curve analysis and area under the curve (AUC) values.

On the role of organic matter composition in fresh-water kaolinite flocculation.

Organic matter has long been understood to affect fine sediment flocculation, yet the specific effects of different types of organic matter remain only partially understood. To address this knowledge gap, laboratory tank experiments were conducted in fresh water to investigate the sensitivity of kaolinite flocculation to varying organic matter species and contents. Three species of organic matter (xanthan gum, guar gum and humic acid) were investigated at varying concentrations.

[Identification and expression of uridine diphosphate glycosyltransferase(UGT) gene family from Dendrobium officinale].

Uridine diphosphate glycosyltransferase(UGT) is a highly conserved protein in plants, which usually functions in secondary metabolic pathways. This study used the Hidden Markov Model(HMM) to screen out members of UGT gene family in the whole genome of Dendrobium officinale, and 44 UGT genes were identified. Bioinformatics was used to analyze the structure, phylogeny, and promoter region components of D.

Survival benefit after neoadjuvant or adjuvant radiotherapy for stage II-III gastroesophageal junction adenocarcinoma: A large population-based cohort study.

Objective: The standard treatment for stage II-III gastroesophageal junction adenocarcinoma (GEJA) remains controversial, and the role of radiotherapy (RT) in stage II-III GEJA is unclear. Herein, we aimed to evaluate the prognosis of different RT sequences and identify potential candidates to undergo neoadjuvant RT (NART) or adjuvant RT (ART).

Materials And Methods: In total, we enrolled 3,492 patients with resectable stage II-III GEJA from the Surveillance, Epidemiology, and End Results (SEER) database, subsequently assigned to three categories: TN, TN, and TN.

Exceptional increases in fluvial sediment fluxes in a warmer and wetter High Mountain Asia.

Rivers originating in High Mountain Asia are crucial lifelines for one-third of the world’s population. These fragile headwaters are now experiencing amplified climate change, glacier melt, and permafrost thaw. Observational data from 28 headwater basins demonstrate substantial increases in both annual runoff and annual sediment fluxes across the past six decades.

Prediction research on sedimentation balance of Three Gorges Reservoir under new conditions of water and sediment.

Influenced by climate change and human activities, especially the completion and operation of cascade reservoirs in the middle and lower reaches of Jinsha River since 2012, new changes have taken place in the water and sediment characteristics of the Three Gorges Reservoir (TGR) in recent years. In this paper, a one-dimensional unsteady water and sediment mathematical model of the main and tributary rivers of the TGR is established, and the main calculation parameters of the model are calibrated with the measured water and sediment data from January 1, 2008 to December 31, 2017. In view of the different combinations of inflow water and sediment that may occur in the TGR under the condition of new water and sediment, the long-term changes of sediment erosion and deposition and the balance of reservoir deposition in the TGR are studied using the model.

Chemokine CCL2 impairs spatial memory and cognition in rats via influencing inflammation, glutamate metabolism and apoptosis-associated genes expression- a potential mechanism for HIV-associated neurocognitive disorder.

Aims: To explore the role of chemokine CC motif ligand 2 (CCL2) in spatial memory and cognition impairment, and the underlying mechanisms focused on inflammatory, glutamate metabolistic and apoptotic- associated mRNA expression.

Materials And Methods: Stereotaxic surgery was performed here to establish a rat model by bilateral intra-hippocampal injection of CCL2. Morris water maze (MWM) and Novel object recognition test (NORT) were used to assess the learning, memory and cognitive ability respectively.

Response of phytoplankton to banana cultivation: A case study of Lancang-Mekong River, southwestern China.

This study examined the possible effects of banana cultivation on phytoplankton biomass and community structure in southwest China along the Lancang-Mekong River. Water and phytoplankton samples were collected on March (dry season) and August (rainy season), and physical-chemical properties of water, phytoplankton biomass and community structure were determined. The results indicated that the banana cultivation resulted in increases in sediment, total phosphorus (TP) and total nitrogen (TN) concentrations at estuaries of Lancang-Mekong River branches.

Influence of turbid flood water release on sediment deposition and phosphorus distribution in the bed sediment of the Three Gorges Reservoir, China.

Excessive phosphorus (P) loading was identified as an urgent problem during the post-Three Gorges Reservoir (TGR) period. Turbid water with high suspended sediment loads has been periodically released during the flood season to mitigate sediment deposition in the TGR, but limited attention has been paid to its effect on the distribution of P in bed sediment within the reservoir. In this study, field surveys, historical monitoring data related to sediment deposition, and physiochemical properties and the fractional P content in the mainstream surface sediment and representative column sediment, were used to investigate the effect of turbid flood water release on P distribution in bed sediment.