Front Cardiovasc Med
December 2024
[This corrects the article DOI: 10.3389/fcvm.2023.
View Article and Find Full Text PDFThe disruption of the local microenvironment subsequent to spinal cord injury (SCI) leads to a substantial loss of neurons in the affected region, which is a major contributing factor to impaired motor function recovery in patients. Fibroblast growth factor 20 (FGF20) is a neurotrophic factor that plays a crucial role in neuronal development and homeostasis. In this study, the recombinant human FGF20 (rhFGF20) was found to mitigate the process of necroptosis in a mouse model of SCI, thereby reducing neural functional deficits and promoting SCI repair.
View Article and Find Full Text PDFBMC Cardiovasc Disord
October 2023
Introduction: Renal artery stenosis (RAS) is a significant reason for secondary hypertension. Impaired renal function and subsequent cardiopulmonary dysfunction could also occur. Patients of non-atherosclerotic RAS has a relatively young age and long life expectancy.
View Article and Find Full Text PDFFront Cardiovasc Med
June 2023
Patients with Takayasu arteritis (TA) and descending aorta involvement often experience insidious onset and slow progression, leading to irreversible vascular lesions despite medication therapy. Surgical management plays a crucial role in resolving hemodynamic disturbances and has shown promise in improving the outcomes of this patient population, owing to significant advancements in surgical expertise. However, studies focusing on this rare disease are lacking.
View Article and Find Full Text PDFBackground: The novel coronavirus disease (COVID-19) spread fast throughout China and the rest of the world, prompting the World Health Organization to declare a worldwide pandemic on March 11, 2020. Many countries have implemented travel bans, lockdowns, and stay-at-home policies to combat the spread of the COVID-19 pandemic. This study aimed to investigate the risk factors of mental health problems among international students stranded outside of China during the pandemic.
View Article and Find Full Text PDFEvaluation refers to a systematic collection of data and utilization of that data to improve the program or project. It provides data to judge whether the program attained its goals and to help plan future training. This study aimed to implement an exploratory sequential research framework to evaluate the Master Trainer-Faculty Professional Development Program (MT-FPFP).
View Article and Find Full Text PDFA rational molecule design strategy based on scaffold hopping was applied to discover novel leads, and then a series of novel pyrazole amide derivatives were designed, synthesized, characterized, and evaluated for their antifungal activities. Bioassay results indicated that some target compounds such as , , and showed good in vivo antifungal activities; among them, exhibited commendable in vivo protective activity with an 89% inhibition rate against on cucumber at 100 μg/mL that is comparable to positive controls boscalid, isopyrazam, and fluxapyroxad. Microscopy observations suggested that affects the normal fungal growth.
View Article and Find Full Text PDFPurpose: To observe the clinical efficacy of cetuximab combined with cisplatin in gastric cancer patients, and to explore its potential mechanism so as to provide references for clinical chemotherapeutic drugs for gastric cancer.
Methods: A total of 122 gastric cancer patients undergoing chemotherapy in our hospital from August 2014 to June 2017 were enrolled and divided into cetuximab group (n=64) and cetuximab + cisplatin group (n=58) according to the chemotherapy regimen. The clinical efficacy, prognosis, adverse reactions and immune status were compared between the two groups of patients.