Publications by authors named "Yini Wen"
Background: Intravenous immunoglobulin (IVIG) resistance may be an increased risk of coronary artery lesions which is the serious complication of Kawasaki disease (KD). Early and accurate identification of IVIG-resistant patients has an important clinical value.
Objective: To establish a new predicting model by detecting the pyroptosis markers with other clinical indicators.
Article Synopsis
- Neutrophil extracellular traps (NETs) are key players in inflammation, but their role in juvenile idiopathic arthritis (JIA) is not well-understood; this study investigates NET formation in different JIA subtypes and the impact of TNF-α inhibitors.
- JIA-derived neutrophils displayed greater ability to release NETs, especially when stimulated by TNF-α, with excess NET formations found in patients compared to healthy controls, correlating with higher disease activity.
- The findings suggest that NETs contribute to inflammation in JIA and that circulating NET products may serve as potential diagnostic markers for the condition.
An early predictive model for Kawasaki disease shock syndrome in children in central China.
Front Cardiovasc Med
May 2024
Introduction: This study aims to analyze the clinical features of Kawasaki disease (KD) shock syndrome (KDSS) and explore its early predictors.
Methods: A retrospective case-control study was used to analyze KD cases from February 2016 to October 2023 in our hospital. A total of 28 children with KDSS and 307 children who did not develop KDSS were included according to matching factors.
Objectives: To investigate the clinical manifestations and laboratory examination results of children with Kawasaki disease complicated by macrophage activation syndrome (KD-MAS), and to provide a basis for identifying early warning indicators for the early diagnosis and treatment of KD-MAS.
Methods: A retrospective study was performed on 27 children with KD-MAS (KD-MAS group) and 110 children with KD (KD group) who were admitted to Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, from January 2014 to January 2022. Clinical and laboratory data were compared between the two groups.