The CsDof1.8-CsLIPOXYGENASE09 module regulates C9 aroma production in cucumber.

Nine-carbon aldehydes and their relative alcohols (C9 aromas) are the main aroma compounds of cucumber (Cucumis sativus L.) fruits and provide a unique cucumber-like note. However, the key regulators of C9 aroma accumulation in cucumber fruit are poorly characterized.

Identification and characterization of CsERECTA, a major gene controlling stem elongation through regulating GA biosynthesis in cucumber.

Dwarfing is an ideal agronomic trait in crop breeding, which can improve lodging resistance and increase crop productivity. In this study, we identified a dwarf mutant cp-3 from an EMS-mutagenized population, which had extremely short internodes, and the cell length and number of internodes were significantly reduced. Meanwhile, exogenous GA treatment partially rescued the plant height of the cp-3.

β-Sitosterol attenuates anlotinib resistance in non-small cell lung cancer cells by inhibiting miR-181a-3p/SHQ1 signaling.

Anlotinib is used for the treatment of advanced non-small cell lung cancer; however, the emergence of drug resistance limits its clinical application. β-sitosterol may also be used to treat lung cancer, but there have been no studies evaluating β-sitosterol against anlotinib-resistant lung cancer. The purpose of this study was to determine the mechanism by which β-sitosterol enhances the sensitivity of lung cancer cells to anlotinib.

Astragaloside IV Overcomes Anlotinib Resistance in Non-small Cell Lung Cancer through miR-181a-3p/UPR-ERAD Axis.

Background: Astragaloside IV (AS-IV) has been shown to have a curative effect on non-small cell lung cancer (NSCLC). This study aimed to elucidate the role of AS-IV in NSCLC cell anlotinib resistance (AR).

Methods: The NSCLC/AR cells, resistant to anlotinib, have been produced.

Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways.

The stress response molecule nuclear protein‑1 (NUPR1) is essential for the growth of multiple types of human malignant tumor cells. However, the significance of NUPR1 in lung cancer is still not entirely elucidated. Therefore, this study is aimed to explore the function and underlying mechanisms of NUPR1 in lung cancer.

Screening and Identification of Garlic Leaf Blight ()-Resistant Mutants Induced by Ethyl Methane Sulphonate.

Garlic ( L.) is a popular condiment used as both medicine and food. Garlic production in China is severely affected by continuous cropping and is especially affected by leaf blight disease.

Impact of Resistant Rootstocks on Fruit and Development.

Plant grafting can provide resistance to nematodes. There is a distinct need to determine the role of -resistant rootstocks on the growth and quality of grafted cucumber plants. Cucumber ( L.

Quantitative trait locus mapping of fruit aroma compounds in cucumber ( L.) based on a recombinant inbred line population.

The fresh and unique flavor of cucumber fruits, mainly composed of aldehydes and alcohols, is one of its most important fruit qualities. However, little is known about the genetic basis of aroma compounds in cucumber fruit and the related quantitative trait loci (QTLs). In this study, genomic screening of QTLs underlying aroma compounds was performed based on the genetic linkage map constructed using 1301 single-nucleotide polymorphism (SNP) markers from genotyping-by-sequencing of a recombinant inbred line (RIL) population developed from Q16 × Q24.

COL3A1 Overexpression Associates with Poor Prognosis and Cisplatin Resistance in Lung Cancer.

Background: Collagen type III alpha 1 chain (COL3A1) is reported to mediate drug resistance in various cancers, and public database analysis indicated its overexpression in lung cancer.

Aims: To investigate the effects of COL3A1 on modulating cisplatin (DDP) resistance in lung carcinoma.

Study Design: A cell study.

Transcriptomic and Histological Analysis of the Response of Susceptible and Resistant Cucumber to Infection Revealing Complex Resistance Multiple Signaling Pathways.

The root-knot nematode (RKN), , is a devastating pathogen for cucumber ( L.) specially in production under protected environments or continuous cropping. High level RKN resistance has been identified in African horned melon (CM).

Relationship between key environmental factors and profiling of volatile compounds during cucumber fruit development under protected cultivation.

To provide precision management of cucumber under protected cultivation, the relationships between environmental factors and daily increment of aroma in two lines were analyzed during development, using Pearson correlation and stepwise regression. Irrespective of the line tested, the daily increment of volatile compounds and C6 aldehydes were positively correlated with average daily light intensity (X), while the daily increment of C9 aldehydes was negatively correlated with average daily relative humidity (X) and average daytime relative humidity (X). X was considered as the most significant environmental factor which affected the daily increment of volatile compounds in both lines, X was the environmental factor which affected the daily increment of C9 aldehydes most in No.