Adaptive median filter salt and pepper noise suppression approach for common path coherent dispersion spectrometer.

The Common-path Coherent-dispersion Spectrometer (CODES), an exoplanet detection instrument, executes high-precision Radial Velocity (RV) inversions by recording the phase shifts of interference fringes. Salt-and-pepper noise caused by factors such as improper operation of the CCD probe/analog-to-digital converter and strong dark currents may interfere with the phase information of the fringe. This lowers the quality of the interfering fringe image and significantly interferes with the RV's inversion.

Expression profile of long noncoding RNAs and comprehensive analysis of lncRNA-cisTF-DGE regulation in condyloma acuminatum.

Objective: To identify differentially expressed long noncoding RNAs (lncRNAs) in condyloma acuminatum (CA) and to explore their probable regulatory mechanisms by establishing coexpression networks.

Methods: High-throughput RNA sequencing was performed to assess genome-wide lncRNA expression in CA and paired adjacent mucosal tissue. The expression of candidate lncRNAs and their target genes in larger CA specimens was validated using real-time quantitative reverse transcriptase polymerase chain reaction (RT‒qPCR).

Alteration of RNA m6A methylation mediates aberrant RNA binding protein expression and alternative splicing in condyloma acuminatum.

Background: Condyloma acuminatum (CA) is caused by low-risk human papillomavirus, and is characterized by high recurrence after treatment. The RNA modification N6-methyladenosine (m6A) plays an important role during diverse viral infections, including high-risk HPV infection in cervical cancer. However, it is unclear whether low-risk HPV infection changes the RNA m6A methylation in CA.

Insecticidal Activity of Essential Oils and Their Synergistic Effect on Improving the Efficacy of β-Cypermethrin against .

We screened the contact activity of 32 commercial essential oils (EOs) and their synergistic effect with β-cypermethrin against . Results showed that the most effective EOs against were from , , and , with LD values of less than 500 μg/insect. The most potent synergistic effects of β-cypermethrin on were from and .

Digital Image Analysis-Based Evaluation of Claudin-1 and Claudin-7 Delocalization in Cutaneous Squamous Cell Carcinoma and in Its Precancerous State.

Accumulating evidence has revealed that delocalization of the transmembrane proteins, Claudin-1 and Claudin-7, to the cytoplasm and/or nucleus occurs in various tumors. However, their subcellular distribution in terms of the membrane, cytoplasm, and nucleus and relationship with signaling pathways have not been elucidated during carcinogenesis. We first determined the expression of these proteins in the membrane, cytoplasm, and nucleus using ImageJ software and automatically collected the immunohistochemical quantification of dysplasia (actinic keratosis (AK)), carcinoma in situ (CIS; Bowen's disease (BD)), and invasive cutaneous squamous cell carcinoma (SCC) for digital image analysis (DIA).

Evaluation of Serum Proinflammatory Cytokine IL-17A and Tight Junction Protein Claudin-1 in Psoriasis.

Objective: This study aimed to estimate serum IL-17A and Claudin-1 levels, investigate their correlation, and evaluate their diagnostic significance as potential blood-based biomarkers in psoriasis.

Methods: Serum IL-17A and Claudin-1 concentrations were determined using enzyme-linked immunosorbent assay (ELISA). Statistical analyses were performed to determine differences in serum levels of IL-17A and Claudin-1, their bivariable correlation with psoriasis severity, as Psoriasis Area Severity Index (PASI), and their predictive abilities using receiver operating characteristic (ROC) curves.

Optimal optical path difference of an asymmetric common-path coherent-dispersion spectrometer.

Optical path difference (OPD) is a very significant parameter in the asymmetric common-path coherent-dispersion spectrometer (CODES), which directly determines the performance of the CODES. In order to improve the performance of the instrument as much as possible, a temperature-compensated optimal optical path difference (TOOPD) method is proposed. The method does not only consider the influence of temperature change on the OPD but also effectively solves the problem that the optimal OPD cannot be obtained simultaneously at different wavelengths.

Microbiome in Healthy Women Between Two Districts With Different Air Quality Index.

Although the diversity and abundance of skin microbiome are mainly determined by intrinsic factors, including gender, age, anatomical site, and ethnicity, we question whether facial microbiome could be affected by long-term exposure to airborne pollution. Using 16S ribosomal RNA (rRNA) gene amplicon sequencing, we analyzed the facial bacterial microbiome of healthy and young Chinese women (25-35 years old) between two districts with different air quality indices (AQIs) in Zhejiang Province. The overall microbiome structure was obviously different between these two districts.

Hyperspectral deep convolution anomaly detection based on weight adjustment strategy.

Hyperspectral anomaly detection has garnered much research in recent years due to the excellent detection ability of hyperspectral remote sensing in agriculture, forestry, geological surveys, environmental monitoring, and battlefield target detection. The traditional anomaly detection method ignores the non-linearity and complexity of the hyperspectral image (HSI), while making use of the effectiveness of spatial information rarely. Besides, the anomalous pixels and the background are mixed, which causes a higher false alarm rate in the detection result.

EGFR inhibitor gefitinib regulates barrier function in human epidermal keratinocytes via the modulation of the expression of claudins.

Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, has been frequently used in targeted therapy for lung cancer. However, the widespread use of gefitinib in targeted therapy for patients with lung cancer is hampered by its common skin toxicities. The present study aimed to investigate the mechanisms underlying the skin toxicities of gefitinib.

Histopathological diagnosis of persistent pruritic eruptions associated with adult-onset Still's disease.

Aims: Persistent pruritic eruptions (PPEs), presenting with dyskeratotic keratinocytes histologically, are characteristic skin rash in patients with adult-onset Still's disease (AOSD). The lesions may be histologically similar to other entities that present with dyskeratosis. In the present study, we compared the histopathological features between PPEs and other entities presenting with dyskeratosis.

Ultrasensitive amperometric aptasensor for the epithelial cell adhesion molecule by using target-driven toehold-mediated DNA recycling amplification.

An amperometric aptasensor is reported for the electrochemical determination of the epithelial cell adhesion molecule (EpCAM). It is based on a combination of EpCAM-driven toehold-mediated DNA recycling amplification, the specific recognition of EpCAM aptamer, and its binding to EpCAM. Hairpin probe 1 (Hp1) with a toehold region was modified with a 5'-thiol group (5'-SH) and self-assembled onto the surface of a gold electrode.

Biological therapy of traditional therapy-resistant adult-onset Still's disease: an evidence-based review.

Background: Biotherapy is becoming increasingly important in the treatment of adult-onset Still's disease (AOSD). The aim of our study was to evaluate the efficacy and safety of biological therapy for AOSD resistant to traditional therapy.

Patients And Methods: Database of Library of Congress, the PubMed, and Web of Science Core Collection were used to retrieve relevant articles published in English language until March 2017.