Publications by authors named "Yinhu Pan"
Axitinib (AXTN) is an oral tyrosine kinase inhibitor for the treatment of early to advanced renal cell carcinoma. In this work, solvates of AXTN were prepared in five solvents and subjected to desolvation treatment. The crystal form A of AXTN can form solvates in acetonitrile, DMF, acetic acid, acetic acid + water, and methanol.
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- * Various models, including the Yaws model, were used to correlate experimental solubility data, with the Yaws model providing the best fit across all solvents.
- * Thermodynamic analysis indicated that the dissolution of OHP is an endothermic process with increasing entropy, supported by calculations of significant thermodynamic properties using the van't Hoff model.