Publications by authors named "Yinhsuan Michely Chen"
Glioblastoma multiforme is an aggressive malignancy with a dismal 5-year survival rate of 5-10%. Current therapeutic options are limited, due in part to drug exclusion by the blood-brain barrier (BBB). We have previously shown that high-amplitude repetitive transcranial magnetic stimulation (rTMS) in rats allowed the delivery across the BBB of an IGF signaling inhibitor-IGF-Trap.
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- Pediatric high-grade gliomas (pHGG) represent 8-12% of brain tumors in children, with a poor prognosis and median survival of 9-15 months.
- The IGF-1R gene amplifications may contribute to the aggressive nature of pHGG, but the effectiveness of IGF inhibitors like IGF-Trap is still being studied.
- Research showed that IGF-1R is involved in cell growth and survival in pHGG cells, and IGF-Trap can inhibit cell proliferation and help prevent cell death in nutrient-deprived conditions.
Article Synopsis
- The insulin-like growth factor (IGF)-axis is linked to cancer progression and is a promising target for treatment, but existing therapies face challenges due to insulin receptor interference.
- Several drugs targeting the IGF-I receptor have been tested in clinical trials but have not yet been successfully used in practice, prompting the development of the IGF-Trap, a new anti-cancer therapeutic.
- The IGF-Trap has shown superior binding affinity and effectiveness in reducing cancer cell spread compared to current treatments and offers a potential biomarker for assessing drug efficacy.