Clinical Significance of HHLA2 as a Novel Therapeutic Target for Colorectal Cancer.

Background: Colorectal cancer (CRC) is a high-indence malignance of the digestive system with a high mortality rate in the world.

Aims: The results are desired to provide an important theoretical basis for discovering new therapeutic targets for CRC.

Objectives: The expression of human endogenous retrovirus-H-long terminal repeat association protein 2 (HHLA2) in human CRC was detected to explore its correlationship with clinicopathological features and prognosis of patients and its potential in treating CRC.

Associations between specialty care and improved outcomes among patients with diabetic foot ulcers.

Objective: Specialty care may improve diabetic foot ulcer outcomes. Medically underserved populations receive less specialty care. We aimed to determine the association between specialty care and ulcer progression, major amputation, or death.

Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation.

Background: Abnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer's disease (AD). However, the sensitivity of cholinergic neurons to AD-like tau accumulation and strategies to ameliorate tau-disrupted spatial memory in terms of neural circuits still remain elusive.

Methods: To investigate the effect and mechanism of the cholinergic circuit in Alzheimer's disease-related hippocampal memory, overexpression of human wild-type Tau (hTau) in medial septum (MS)-hippocampus (HP) cholinergic was achieved by specifically injecting pAAV-EF1α-DIO-hTau-eGFP virus into the MS of ChAT-Cre mice.

Associations between body mass index, weight loss and overall survival in patients with advanced lung cancer.

Background: Weight loss (WL) has been associated with shorter survival in patients with advanced cancer, while obesity has been associated with longer survival. Integrating body mass index (BMI) and WL provides a powerful prognostic tool but has not been well-studied in lung cancer patients, particularly in the setting of clinical trials.

Methods: We analysed patient data (n = 10 128) from 63 National Cancer Institute sponsored advanced non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) trials.

A straightforward and sensitive "ON-OFF" fluorescence immunoassay based on silicon-assisted surface enhanced fluorescence.

A straightforward immunoassay based on silicon-assisted surface enhanced fluorescence (SEF) has been demonstrated using a silicon-based fluorescent immune substrate and silver-antibody nanoconjugate (SANC). The P-doped, (100) oriented silicon wafers are used for both fluorophore attachment and antigen immobilization. The silicon substrate offers a very low blank signal in the "OFF" state, due to its fluorescence quenching effect.

Predicting risk of chemotherapy-induced severe neutropenia: A pooled analysis in individual patients data with advanced lung cancer.

Objectives: Neutropenia is associated with the risk of life-threatening infections, chemotherapy dose reductions and delays that may compromise outcomes. This analysis was conducted to develop a prediction model for chemotherapy-induced severe neutropenia in lung cancer.

Materials And Methods: Individual patient data from existing cooperative group phase II/III trials of stages III/IV non-small cell lung cancer or extensive small-cell lung cancer were included.

[Cold hardiness of Pinus ponderosa, P. banksian and P. tabulaeformis].

By the method of artificial freezing, this paper made a comparative study on the cold hardiness of Pinus ponderosa, P. banksiana and P. tabulaeformis, with their inherent mechanisms approached.