Multi-parametric diffusion spectrum imaging in tuberous sclerosis complex: Identifying cortical tubers and predicting genotypes.

Objectives: This study employed advanced MRI diffusion imaging techniques to identify cortical tubers in Tuberous Sclerosis Complex (TSC) patients and compared the diagnostic efficacy of various diffusion model parameters in predicting TSC genotypes.

Methods: From July 2019 to April 2024, a prospective study was conducted at our Hospital. Participants meeting specific criteria underwent genetic testing and Diffusion Spectrum Imaging (DSI) data collection.