Publications by authors named "Yingzheng Ji"
Article Synopsis
- Osteosarcoma, the most common malignant bone tumor in kids and teens, currently has no effective cure, and the study explores how focal adhesion influences tumor behavior and potential therapies.
- Researchers analyzed data from various databases to identify differentially expressed genes related to focal adhesion and their prognostic significance in osteosarcoma.
- The study revealed 50 up-regulated and 28 down-regulated genes, with a focus on 10 candidate genes; CAV1, ZYX, and ITGA5 were particularly noted for their significant impact on survival outcomes in osteosarcoma patients.
Climbing plants are important components of tropical and many temperate forest ecosystems. Current studies regard climbing plants as a single ecological plant type and ignore the ecological differences resulting from their climbing mechanisms, which may lead to a misrepresentation of the role of climbing plants in forest dynamics. Based on behavioral traits and economic traits of climbing plants, we test the hypothesis that tendril climbers and stem twiners are characterized by different resource acquisition strategies.
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- Bone metastasis is common in renal cell carcinoma and has a poor prognosis, prompting the need to explore potential therapeutic targets through a detailed analysis of single-cell transcriptomes from both primary and metastatic tumors.* -
- The study reveals significant immune deficiencies in the bone metastatic environment, highlighting the role of cancer-associated fibroblasts and a dominance of immune inhibitory T cells, which could be targeted for treatment.* -
- Dynamic changes among various cell types, including the transition of myeloid-derived suppressor cells to macrophages, are observed, pointing to potential avenues for developing new therapies for bone metastatic renal cell carcinoma.*
Background: Although there have been several risk factors reported for implant failure (IF), little consensus exists. Potential applicable measures to protect patients from IF are relatively few. This study aimed to discover new risk factors for IF and explore potential protective measures from IF after total spondylectomy for spinal tumors.
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- - The study compares surgical outcomes of two treatments for spinal metastasis: piecemeal spondylectomy and separation surgery, focusing on patient data collected between August 2017 and April 2020.
- - Results showed that while both procedures improved neurological status, piecemeal spondylectomy had significantly more blood loss and longer operation times compared to separation surgery.
- - No significant difference in overall survival was found, but separation surgery was linked to better progression-free survival and fewer complications and local recurrences, suggesting it may be the better option for patients.
Breast cancer (BC) is characterized by high incidences of bone metastases. Current treatment strategies for BC bone metastases primarily focused on breaking the 'vicious osteolytic cycle'. Platelet-activating factor (PAF) is a potent phospholipid mediator, which has previously reported biological activities in BC progression and osteoclast differentiation by activating its receptor PAF receptor (PTAFR).
View Article and Find Full Text PDFHIF-1α activates hypoxia-induced PFKFB4 expression in human bladder cancer cells.
Biochem Biophys Res Commun
July 2016
PFKFB4 is reported to regulate glycolysis by synthesizing fructose-2, 6-bisphosphate (F2,6BP) and has proved to be associated with most malignancies. However, the underlying mechanism for increased PFKFB4 expression in bladder cancer remains unclear. The present study demonstrated that PFKFB4 was overexpressed in bladder cancer tissues.
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